Differential Growth Properties of Normal and Malignant Esophageal Epithelial Cells: A Possible Cross Talk between Transforming Growth Factor-.BETA.1 and Epidermal Growth Factor Signaling

Secretory phospholipase A2 is required to produce histologic changes associated with gastroduodenal reflux in a murine model

“…20,21 This is important considering that EGF/EGF receptor signaling is an important pathway regulating cell proliferation in the esophageal mucosa. 22 In macrophages sPLA 2 has been demonstrated to mediate phosphorylation of Akt, which leads to a downstream growth regulatory effect in these cells. 23 In murine small intestinal tissue an sPLA 2like molecule has been shown to bind to EGF and influence cell proliferation.…”

The Secretory Phospholipase A2 Gene is Required for Gastroesophageal Reflux-Related Changes in Murine Esophagus

“…27 These are relevant findings considering that EGF/EGFR signaling is an important pathway regulating cell proliferation in the esophageal mucosa as well as its described role in esophageal malignancy. 28,29 In a non-EGF-dependent pathway, sPLA 2 expressed by macrophages has been demonstrated to mediate phosphorylation of Akt which leads to downstream growth regulatory effect in these cells. 30 We have planned studies using these surrogate markers of EGF signaling pathways to establish the link between sPLA 2 and EGF, which may increase our understanding of sPLA 2 as a growth-regulating factor in the esophageal mucosa.…”