The Secretory Phospholipase A2 Gene is Required for Gastroesophageal Reflux-Related Changes in Murine Esophagus

Abstract

The presence of sPLA(2) is necessary for early mucosal hyperplasia produced by exposure of the esophagus to gastroduodenal contents. sPLA(2) expression is upregulated by gastroduodenal reflux, strengthening its role as a critical mediator of early mucosal hyperplasia.

Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer

“…Recently, Babu et al. 30 have reported that PLA2G2A is required for gastro‐oesophageal reflux‐related changes in murine oesophagus. Up‐regulation by gastroduodenal reflux strengthened its role as a critical mediator of early mucosal hyperplasia.…”