“…In almost all malignancy studies, microRNA (miRNAs) are found especially critical because they can be the results of chromosome lesions, modulated by classic cell signaling, and they themselves can act as both oncogenes and tumor suppressors ( Bartel, 2004 ; Lan et al, 2015 ). Recently, a close association between miRNAs and pancreatic cancer tumorigenesis has been elucidated ( Lai et al, 2015 ; Pavlakis et al, 2013 ). Various miRNAs, such as miR-200 ( Yu et al, 2010 ), miR-146a ( Li et al, 2010 ), miR-486 ( Mees et al, 2009 ) and the let-7 family ( Li et al, 2009b ) have been confirmed to be tumor suppressors; meanwhile, pancreatic cancer malignancy was found positively associated with miR-196a ( Huang et al, 2014 ), miR-212 ( Ma et al, 2014 ) and miR-31 ( Laurila et al, 2012 ).…”