MicroRNA-140 regulates cell growth and invasion in pancreatic duct adenocarcinoma by targeting iASPP

Liang, Shuai; Gong, Xuejun; Zhang, Gewen; Huang, Gengwen; Lu, Yao; Li, Yixiong

doi:10.1093/abbs/gmv127

Cited by 22 publications

(18 citation statements)

References 35 publications

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“…Numerous studies have reported that miR-140 was frequently deregulated in various types of cancers. Reduced expression levels of miR-140 has been demonstrated in pancreatic duct adenocarcinoma (29), lung (30,31), colorectal (32), ovarian (33), esophageal (34) and tongue cancer (35). However, miR-140 also has been found upregulated in spinal chordoma (36) and breast cancer (37).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, miR-140 overexpression suppressed non-small cell lung cancer growth and metastasis in vivo (39). Liang et al found that ectopic of miR-140 expression decreased pancreatic duct adenocarcinoma cell growth and invasion (29). Zhang et al demonstrated that miR-140 acted as a tumor suppressor in colorectal cancer by inhibiting cell proliferation, migration and invasion (32).…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, several target genes of miR-140 have been validated, including iASPP (29), ATP6AP2 (30), ATP8A1 (31), VEGFA (32), PDGFRA (33), Slug (34) and IGF-1R (39). However, no target of miR-140 has been identified in glioma.…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9

et al. 2016

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Glioma is the most frequent primary malignant tumor of the human brain. Recently, great progress has been made in the combined therapy of glioma. However, the clinical effects of these treatments and prognosis for patients with glioma remains poor. MicroRNAs (miRNAs) have been demonstrated to play important roles in the initiation and progression of various types of human cancers, also including glioma. The present study investigated the expression patterns of microRNA‑140 (miR-140) in glioma, and the roles of miR-140 in glioma cell proliferation, migration and invasion. The results showed that miR-140 was significantly downreuglated in glioma tissues and cell lines, and low expression levels of miR-140 were correlated with World Health Organization (WHO) grade and Karnofsky performance score (KPS) of glioma patients. Restoration of miR-140 obviously suppressed glioma cell proliferation, migration and invasion. In addition, a disintegrin and metalloproteinase 9 (ADAM9) was identified as a novel direct target gene of miR-140 in glioma. Furthermore, knockdown of ADAM9 simulated the tumor suppressor functions of miR-140, while overexpression of ADAM9 abrogated these suppressive effects induced by miR-140 in glioma cells. In conclusion, the present study demonstrated the expression and clinical roles of miR-140 in glioma and suggested that miR-140 inhibited proliferation, migration and invasion of glioma cells, partially at least via suppressing ADAM9 expression. Therefore, miR-140 may be a novel candidate target for the development of therapeutic strategies for patients with glioma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9

et al. 2016

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“…Iida et al 119 reported that upregulating miR-125b could suppress P53-dependent apoptosis and induce chemoresistance to doxorubicine, vincristine, etoposide and mafosfamide in Ewing sarcoma/primitive neuroectodermal tumor (EWS) cells. Liang and colleagues 120 demonstrated that overexpression of miR-140 could interfere with the growth and invasion of pancreatic duct adenocarcinoma cells by directly targeting inhibitor of apoptosis-stimulating protein of P53 (iASPP). MiR-122/cyclin G1 interaction was demonstrated to positively regulated P53 protein stability and transcriptional activity and affected doxorubicin sensitivity of human hepatocarcinoma cells 121 .…”

Section: Aberrant Expression Of Mirnas and Cancer Drug Resistancementioning

confidence: 99%

Regulation of multidrug resistance by microRNAs in anti-cancer therapy

An¹,

Sarmiento

Tan

et al. 2017

Acta Pharmaceutica Sinica B

165

132

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Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment. Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly understood. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins expression. Accumulating evidence shows that miRNAs play a key regulatory role in MDR through modulating various drug resistant mechanisms mentioned above, thereby holding much promise for developing novel and more effective individualized therapies for cancer treatment. This review summarizes the various MDR mechanisms and mainly focuses on the role of miRNAs in regulating MDR in cancer treatment.

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“…In western industrialized countries, PCa is generally considered as the common malignant disease and the second most common cause of cancer-related death among men. 30 However, the miR-140 prognostic relevance and effects in PCa are not clear. 22-24 YES1, a notable member of Src family tyrosinekinases, and has been widely documented to regulate cell growth, adhesion, and F I G U R E 4 miR-140 directly targets the 3′-UTR of YES1 mRNA.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐140 inhibit prostate cancer cell invasion and migration by targeting YES proto‐oncogene 1

Zhao

Jie

et al. 2019

J of Cellular Biochemistry

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Prostate cancer (PCa), which is an aggressive malignancy of the male genitourinary system. In the present study, the effects of microRNA‐140 (miR‐140) on PCa were determined. We transfected miR‐140 mimics or negative control into PCa cells, and we used MTT, wound healing, and Transwell assays for determining the capacities of miR‐140 in cell proliferation, migration, and invasion, respectively. We also confirmed the relationship between miR‐140 and YES proto‐oncogene 1 (YES1) using Luciferase reporter assay. The results showed that miR‐140 was downregulated in PCa cells and tissues, and overexpression of miR‐140 could significantly suppress their capacities of proliferation, migration, and invasion. Moreover, YES1 was shown to be a direct target of miR‐140. Moreover, miR‐140 expression is negatively correlated with YES1 levels. miR‐140 exhibits significant tumor‐suppressive effects in PCa by inhibiting YES1. The study indicated that miR‐140 and YES1 could be the potential targets for PCa therapy.

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MicroRNA-140 regulates cell growth and invasion in pancreatic duct adenocarcinoma by targeting iASPP

Cited by 22 publications

References 35 publications

MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9

MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9

Regulation of multidrug resistance by microRNAs in anti-cancer therapy

MicroRNA‐140 inhibit prostate cancer cell invasion and migration by targeting YES proto‐oncogene 1

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