Differential expression profiles of circulating microRNAs in newborns associated to maternal pregestational overweight and obesity

Méndez-Mancilla, Alejandro; Lima‐Rogel, Victoria; Toro‐Ortíz, Juan Carlos; Escalante-Padrón, Francisco J.; Monsiváis‐Urenda, Adriana; Noyola, Daniel E.; Salgado‐Bustamante, Mariana

doi:10.1111/ijpo.12247

Cited by 24 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is considerable evidence about genetic contributions to appetitive traits, such as food intake self‐regulation or its inverse, impulsivity, uncontrolled or emotional eating, satiety responsiveness and food cue responsiveness, food preferences and choice, and food intake as well as taste receptors . Another dimension to the genetic evidence is about epigenetic effects associated with maternal obesity and prenatal diet . Paternal epigenetic effects have also been reported.…”

Section: Resultsmentioning

confidence: 99%

“…128 Another dimension to the genetic evidence is about epigenetic effects associated with maternal obesity and prenatal diet. [129][130][131] Paternal epigenetic effects have also been reported. Gilbert and Epel 132 for example, noted that "paternal obesity may trigger epigenetic changes in the sperm chromosomes, making offspring more susceptible for obesity and metabolic disease" (p. 303).…”

Section: Genetic Contributions To Behavior Development Eating Anmentioning

confidence: 96%

See 1 more Smart Citation

A biopsychosocial approach to processes and pathways in the development of overweight and obesity in childhood: Insights from developmental theory and research

Russell

2019

Obesity Reviews

View full text Add to dashboard Cite

Summary Childhood obesity has reached alarming proportions in many countries. There is consensus that both biological (especially genetic) and environmental (including psychosocial) factors contribute to weight gain and obesity in childhood. Research has identified extensive risk or predictive factors for childhood obesity from both of these domains. There is less consensus about the developmental processes or pathways showing how these risk factors lead to overweigh/obesity (OW/OB) in childhood. We outline a biopsychosocial process model of the development of OW/OB in childhood. The model and associated scholarship from developmental theory and research guide an analysis of research on OW/OB in childhood. The model incorporates biological factors such as genetic predispositions or susceptibility genes, temperament, and homeostatic and allostatic processes with the psychosocial and behavioral factors of parenting, parental feeding practices, child appetitive traits, food liking, food intakes, and energy expenditure. There is an emphasis on bidirectional and transactional processes linking child biology and behavior with psychosocial processes and environment. Insights from developmental theory and research include implications for conceptualization, measurement, research design, and possible multiple pathways to OW/OB. Understanding the developmental processes and pathways involved in childhood OW/OB should contribute to more targeted prevention and intervention strategies in childhood.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Genetic Contributions To Behavior Development Eating Anmentioning

confidence: 96%

A biopsychosocial approach to processes and pathways in the development of overweight and obesity in childhood: Insights from developmental theory and research

Russell

2019

Obesity Reviews

View full text Add to dashboard Cite

show abstract

“…Individuals with overweight and obesity are at increased risk for cardiovascular diseases, diabetes mellitus, hypertension and certain forms of cancer. Several miRNAs have been shown to be involved in the regulation of lipid metabolism and homoeostasis in childhood obesity, and changes in miRNA expression could participate in the foetal epigenetic programming of metabolic disorders in children born to women affected by obesity . Being born SGA and exhibiting a rapid increase in weight during early childhood and infancy have been strongly linked to a number of long‐term risks including glucose intolerance, type 2 diabetes, higher systolic blood pressure, coronary heart disease and cardiovascular mortality, insulin resistance, elevated plasma cortisol, premature adrenarche and ovarian hyperandrogenism .…”

Section: Discussionmentioning

confidence: 99%

Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There were significant differences in the expression of three different miRNAs (expression of miR-155, miR-181a and miR-221) between newborns of obese women and women within the normal weight range. Depending on these changes, it was thought that alterations in miRNA expression could participate in the epigenetic programming of metabolic disorders in children born to obese women [92].…”

Section: Microrna'smentioning

confidence: 99%

Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders

Sanli

Kabaran

2019

View full text Add to dashboard Cite

Background: Maternal obesity and maternal overnutrition, can lead to epigenetic alterations during pregnancy and these alterations can influence fetal and neonatal phenotype which increase the risk of metabolic disorders in later stages of life. Objective: The effects of maternal obesity on fetal programming and potential mechanisms of maternal epigenetic regulation of gene expression which have persistent effects on fetal health and development were investigated. Method: Review of the literature was carried out in order to discuss the effects of maternal obesity and epigenetic mechanisms in fetal programming of metabolic disorders. All abstracts and full-text articles were examined and the most relevant articles were included in this review. Results: Maternal obesity and maternal overnutrition during fetal period has important overall effects on long-term health. Maternal metabolic alterations during early stages of fetal development can lead to permanent changes in organ structures, cell numbers and metabolism. Epigenetic modifications (DNA methylation, histone modifications, microRNAs) play an important role in disease susceptibility in the later stages of human life. Maternal nutrition alter expression of hypothalamic genes which can increase fetal and neonatal energy intake. Epigenetic modifications may affect the increasing rate of obesity and other metabolic disorders worldwide since the impact of these changes can be passed through generations. Conclusion: Weight management before and during pregnancy, together with healthy nutritional intakes may improve the maternal metabolic environment, which can reduce the risks of fetal programming of metabolic diseases. Further evidence from long-term follow-up studies are needed in order to determine the role of maternal obesity on epigenetic mechanisms.

show abstract

Differential expression profiles of circulating microRNAs in newborns associated to maternal pregestational overweight and obesity

Abstract: Expression of miR-155, miR-181a and miR-221 differs in infants born to obese women compared with infants born to normal weight women. Changes in microRNA expression could participate in the epigenetic foetal programming of metabolic disorders in children born to obese women.

Cited by 24 publications

References 30 publications

A biopsychosocial approach to processes and pathways in the development of overweight and obesity in childhood: Insights from developmental theory and research

A biopsychosocial approach to processes and pathways in the development of overweight and obesity in childhood: Insights from developmental theory and research

Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age

Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders

Contact Info

Product

Resources

About