Differential Expression of Surfactant Protein A in the Nasal Mucosa of Patients With Allergy Symptoms

Wootten, Christopher T.; Labadie, Robert F.; Chen, Anton; Lane, Kirk F.

doi:10.1001/archotol.132.9.1001

Cited by 17 publications

(19 citation statements)

References 23 publications

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“…En corollaire, l'administration de SP-A exogène chez des souris déficientes entraîne l'inhibition de la synthèse d'IgE spécifiques [24]. Chez l'homme, il a été montré que la sécrétion de SP-A au niveau de l'épithélium nasal était plus élevée en cas de rhinite allergique ou de polypes naso-sinusiens par rapport aux sujets sains [25,26]. Les taux sériques de SP-A chez l'homme semblent être directement corrélés à l'éosinophilie sanguine, ce qui paraît contradictoire par rapport aux résultats des modèles murins.…”

Section: Les Protéines a Et D Du Surfactant (Sp-a Et Sp-d) Sont Des Punclassified

Les pneumoprotéines sériques, de nouveaux biomarqueurs pour phénotyper l’asthme du nourrisson ?

Fontaine¹,

Amat²,

Paluel-Marmont³

et al. 2015

Revue Française d'Allergologie

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Il reste difficile actuellement de distinguer a priori les différents phénotypes d'asthme du nourrisson, et notamment de distinguer l'asthme à risque de persistance et de sévérité de l'asthme transitoire. Il est essentiel d'améliorer la prédiction du pronostic de l'asthme au cours de l'enfance, car l'asthme à début précoce concerne une proportion non négligeable, environ 10 %, de la population générale pédiatrique. L'épithélium pulmonaire sécrète différentes protéines, dont certaines, appelées pneumoprotéines, sont dorénavant dosables dans le sérum. Certaines d'entre elles pourraient constituer une piste intéressante dans la recherche de biomarqueurs associés aux phénotypes de l'asthme. AbstractAt present, it is still difficult to distinguish a priori different phenotypes of early-onset asthma in infants, especially to be able to differentiate infants with asthma who are at risk of persistence and severity from those with transient wheezing. It is thus essential to improve the prediction of the prognosis of early-onset asthma because of its high frequency, about 10%, in the pediatric general population. The pulmonary epithelium secretes into the serum a variety of proteins, including some known as pneumoproteins, and these proteins can now be assayed in the serum. Some of them might represent an interesting way in the search of new biomarkers associated with particular asthma phenotypes.

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Section: Les Protéines a Et D Du Surfactant (Sp-a Et Sp-d) Sont Des Punclassified

Les pneumoprotéines sériques, de nouveaux biomarqueurs pour phénotyper l’asthme du nourrisson ?

Fontaine¹,

Amat²,

Paluel-Marmont³

et al. 2015

Revue Française d'Allergologie

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“…Some studies have observed that SP-A is expressed by human nasal mucosa 4,23 and that its expression level is related to the severity of AR. Increased expression of SP-A was also observed in the nasal and sinus mucosae of patients with chronic sinusitis with nasal polyps and allergic fungal sinusitis.…”

Section: Detection Of Specific Antigen Ige Levelsmentioning

confidence: 99%

Protective Effects of Exogenous Surfactant Protein A in Allergic Rhinitis: A Mouse Model

Ren¹,

Deng²,

Xiao³

et al. 2013

Ann Otol Rhinol Laryngol

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Exogenous SP-A had a significant therapeutic effect in mice with AR, and its mechanisms of action included inhibition of the differentiation of Th2 cells in the nasal mucosa, reduced levels of Th2 cytokines, and increased levels of Th1 cytokines. Together, these effects corrected the Th1/Th2 imbalance, inhibited the increase of specific immunoglobulin E production, effectively reduced the symptoms of AR, and inhibited the development of AR.

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“…The sinonasal mucosa serves as the first line of defense against inhaled pathogens, and it is obvious to anticipate that the same immunological defense mechanisms of SP-A and SP-D also occur in the nasal cavity. Indeed, previous studies have demonstrated an upregulation of SP-A in chronic rhinosinusitis and in the nasal mucosa of patients with allergy [15,16]. Additionally, Woodworth et al [17,18] demonstrated an upregulation of SP-A, -B and -D in chronic rhinosinusitis patients with cystic fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Surfactant Proteins A, B, C and D in the Human Nasal Airway: Associated with Mucosal Glands and Ciliated Epithelium but Absent in Fluid-Phase Secretions and Mucus

Gaunsbaek

Kjeldsen

Svane-Knudsen

et al. 2014

ORL

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Aims: To investigate the presence of surfactant protein (SP) A, B, C and D in nasal airways and to determine whether the proteins exert their main functions in nasal secretions or in the deeper layers of the nasal mucosa. Methods: Volunteers were recruited from the Department of ENT Head and Neck Surgery, Odense University Hospital, Denmark. The study included 39 subjects. Nasal mucosal biopsies were analyzed by immunohistochemistry, and bronchoalveolar and nasal lavages, nasal brush biopsies and nasal mucus were analyzed for SP-A, -B, -C and -D by SDS-PAGE and Western blotting. The presence of SP-A and SP-D in the first three samplings were also analyzed by enzyme-linked immunosorbent assay. Results: In nasal mucosal biopsies, SP-A, -B, -C and -D were all demonstrated in the serous acini of the submucosal glands and in the surface epithelium. SP-D was detected in nasal brush biopsies, whereas the other SPs were absent. Moreover, SP-A, -B, -C and -D were absent in nasal lavage and mucus. Conclusion: SP-A, -B, -C and -D exert their protective effect in the ductal epithelium of the submucosal glands rather than in nasal secretions and mucus. Further studies are required to clarify the functions of these proteins in nasal secretory pathways for understanding upper airway diseases. i 2014 S. Karger AG, Basel

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Differential Expression of Surfactant Protein A in the Nasal Mucosa of Patients With Allergy Symptoms

Cited by 17 publications

References 23 publications

Les pneumoprotéines sériques, de nouveaux biomarqueurs pour phénotyper l’asthme du nourrisson ?

Les pneumoprotéines sériques, de nouveaux biomarqueurs pour phénotyper l’asthme du nourrisson ?

Protective Effects of Exogenous Surfactant Protein A in Allergic Rhinitis: A Mouse Model

Surfactant Proteins A, B, C and D in the Human Nasal Airway: Associated with Mucosal Glands and Ciliated Epithelium but Absent in Fluid-Phase Secretions and Mucus

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