2014
DOI: 10.1159/000369143
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Abstract: Aims: To investigate the presence of surfactant protein (SP) A, B, C and D in nasal airways and to determine whether the proteins exert their main functions in nasal secretions or in the deeper layers of the nasal mucosa. Methods: Volunteers were recruited from the Department of ENT Head and Neck Surgery, Odense University Hospital, Denmark. The study included 39 subjects. Nasal mucosal biopsies were analyzed by immunohistochemistry, and bronchoalveolar and nasal lavages, nasal brush biopsies and nasal mucus w… Show more

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Cited by 8 publications
(5 citation statements)
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References 43 publications
(65 reference statements)
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“…However, the mech-anism for chloride and potassium transport by AE cells is less clear (170). AT II cells are also important for enriching the ALF with surfactant (83,105,199,225) and immunoreactive proteins (27,48,128,211) which facilitate innate immune responses.…”
mentioning
confidence: 99%
“…However, the mech-anism for chloride and potassium transport by AE cells is less clear (170). AT II cells are also important for enriching the ALF with surfactant (83,105,199,225) and immunoreactive proteins (27,48,128,211) which facilitate innate immune responses.…”
mentioning
confidence: 99%
“…21 In a prior analysis by Bräuer et al, 20 acinar epithelial cells of the lacrimal gland and epithelial cells of the conjunctiva and nasolacrimal ducts revealed SP-A and SP-D expression. Gaunsbaek et al 40 found SP-A, SP-B, SP-C, and SP-D in acini of the submucosal glands in nasal mucosa. Saitoh et al 19 investigated submucosal glands of human airway walls and showed a positive SP-A stain over serous cells.…”
Section: Discussionmentioning
confidence: 99%
“…46 In a similar way, SP-B and SP-C may help to improve the flow of secretion material through the duct system of glandular tissues as discussed by Bräuer et al 20 This quality is also helpful in the flow property in human saliva of the parotid gland, submandibular gland, 21 and tear fluid 20 as all four SPs were detected therein. Interestingly, Gaunsbaek et al 40 revealed that in nasal lavage and mucus, the levels of SP-A, SP-B, SP-C, and SP-D were not detectable although they could be demonstrated immunohistochemically in acinar cells of nasal submucosal glands and in the surface epithelium. A possible explanation may be that in nasal seromucosal glands, mucous endpieces predominate, consequently, SPs of serous acini were difficult to be detected by conventional methods.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, the presence of pulmonary surfactant in the upper airways interacting with pulmonary mucus is known since the early 1990s, though it has been poorly studied in comparison with pulmonary surfactant in the deep lung. [4,5,26,27] With this in mind, apart from pulmonary surfactant samples from the distal airways, we also explored pulmonary mucus from mechanically ventilated patients as a potential source of human-derived pulmonary surfactant preparations. The collection of tracheobronchial mucus does not require lung lavage and is routinely collected and discarded during clinical practice.…”
Section: Discussionmentioning
confidence: 99%