Differential Expression of Pd1 and Pdl1 in Oral Potentially Malignant Lesions and Oral Squamous Cell Carcinoma:a Pilot Study

Comparison of PD-L1 Expression in Oral Squamous Cell Carcinoma and Premalignant Lesions of Oral Cavity

“…Nearly all squamous cell carcinomas of oral cavity emerge from premalignant disorders of oral cavity including clinical diseases for example erytheroplakia, leukoplakia, lichen planus, actinic cheilitis, chronic candidiasis and submucous fibrosis etc (Scully, 2014). Dysplastic changes are one of the signs of premalignant lesions with a malignant potential of up to 36% (Dave et al, 2019;Nankivell et al, 2013).…”

“…When programmed death ligand 1 is expressed on cancerous cells, it leads to the complexation of PD-1 and PD-L1 pathway causing exhaustion of T cell functions. In this way the cancer cells evade immune system by protecting themselves from the attack of CD8+ cytotoxic T cells (Dave et al, 2019).Immune checkpoint molecules have a targeted immunotherapy available that can block their action and has a promising role in cancer therapy (Kujan et al, 2020).…”