Differential expression of microRNAs in plasma of patients with prediabetes and newly diagnosed type 2 diabetes

Yan, Shaoying; Wang, Tianqiong; Huang, Sheng‐Wen; Di, Yanan; Huang, Yunzhu; Liu, Xingmei; Luo, Zhijun; Han, Wenping; An, Bangquan

doi:10.1007/s00592-016-0837-1

Cited by 50 publications

(25 citation statements)

References 37 publications

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“…The main characteristics extracted from various datasets are summarized in Table 1, which includes the number of patients investigated, the measurement platform, type of sample used and the identity of miRNAs in the study [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81]. Comparing results from multiple tissues provides an overall view of the impact of miRNAs in T2DM pathology.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

Ding

Liang

et al. 2017

IJMS

106

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MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated these findings and explored the functional effects of the dysregulated miRNAs identified. To investigate the involvement of miRNAs in T2DM, we obtained and analyzed all relevant studies published prior to 18 October 2016 from various literature databases. From 59 independent studies that met the inclusion criteria, we identified 158 dysregulated miRNAs in seven different major sample types. To understand the functional impact of these deregulated miRNAs, we performed targets prediction and pathway enrichment analysis. Results from our analysis suggested that the altered miRNAs are involved in the core processes associated with T2DM, such as carbohydrate and lipid metabolisms, insulin signaling pathway and the adipocytokine signaling pathway. This systematic survey of dysregulated miRNAs provides molecular insights on the effect of deregulated miRNAs in different tissues during the development of diabetes. Some of these miRNAs and their mRNA targets may have diagnostic and/or therapeutic utilities in T2DM.

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Section: Resultsmentioning

confidence: 99%

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

Ding

Liang

et al. 2017

IJMS

106

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“…In another study in a Chinese population, plasma miR-126 was significantly reduced in susceptible individuals and DM patients compared to normal individuals, suggesting that it may serve as a potential biomarker for early identification of individuals susceptible to DM (238). More recently, another study has indicated that plasma levels of miR-1249, miR-320b, and miR-572 might help differentiating patients with prediabetes and newly diagnosed type 2 DM (239). …”

Section: Mirnas In Diabetes Mellitusmentioning

confidence: 99%

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

Lucia

Komici²,

Borghetti

et al. 2017

Front. Med.

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Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions. In this review, we will focus on the role of miRNAs in aging and age-related CVDs as heart failure, hypertension, atherosclerosis, atrial fibrillation, and diabetes mellitus. miRNAs are key regulators of complex biological mechanisms, representing an exciting potential therapeutic target in CVDs. Moreover, one major challenge in geriatric medicine is to find reliable biomarkers for diagnosis, prognosis, and prediction of the response to specific drugs. miRNAs represent a very promising tool due to their stability in the circulation and unique signature in CVDs. However, further studies are needed to investigate their translational potential in the real clinical practice.

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“…If the miR-126 expression is found to be lower than 35 (relative quantification unit), the individual is likely to develop T2DM in the following two years [64]. Similarly, by comparing expression profiles of miRNAs in the plasma of patients with prediabetes and newly diagnosed T2DM, Yan et al demonstrated plasma miR-1249 , miR-320b , and miR-572 levels as potential biomarkers for early diagnosis of T2DM [65]. …”

Section: Mirnas As Type 2 Diabetes (T2dm) Markers and Its Complicamentioning

confidence: 99%

Regulatory Roles of MicroRNAs in Diabetes

Feng

Xing

Xie

2016

IJMS

127

100

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MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multifactorial metabolic disorder affecting >400 million people worldwide. miRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. In this review, we summarize the investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating miRNAs as diagnostic markers for diabetes mellitus.

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Differential expression of microRNAs in plasma of patients with prediabetes and newly diagnosed type 2 diabetes

Abstract: Taken together, our results showed differentially expressed miRNAs in T2D and prediabetes. Plasma hsa-miR-1249, hsa-miR-320b, and hsa-miR-572 may serve as novel biomarkers for diagnosis and potential targets for the treatment for prediabetes and T2D.

Cited by 50 publications

References 37 publications

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

Regulatory Roles of MicroRNAs in Diabetes

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