RETRACTED ARTICLE: Differential Expression of LOXL1-AS1 in Coronary Heart Disease and its Regulatory Mechanism in ox-LDL-Induced Human Coronary Artery Endothelial Cell Pyroptosis

Song, Bingbing; Dang, Haiming; Dong, Ran

doi:10.1007/s10557-021-07274-z

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…Silencing LOXL1-AS1 could promote HCAEC viability and reduce pyroptosis. 9) The above suggests that LOXL1-AS1 is closely associated with cardiovascular disease and that it may serve as a clinically significant predictor. However, its biological effects and regulatory mechanisms have not yet been explained in MIRI.…”

Section: Discussionmentioning

confidence: 99%

“… 21) Furthermore, LOXL1-AS1 enhanced ox-LDL-induced pyroptosis in human coronary endothelial cells by binding miR-16-5p. 9) According to the literature, in coronary heart disease, LOXL1-AS1 was noted to be significantly upregulated in the serum of patients with coronary heart disease and atherosclerosis. Silencing LOXL1-AS1 could promote HCAEC viability and reduce pyroptosis.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, LOXL1-AS1 facilitated gastric cancer occurrence and stemness via regulating the microRNA (miRNA)-708-5p/USF1 pathway. 8) Notably, Song et al 9) reported that the LOXL1-AS1 level was upregulated in patients with coronary heart disease. LOXL1-AS1 enhanced oxidized low-density lipoprotein and caused human coronary artery endothelial cell (HCAEC) pyroptosis.…”

Section: Introductionmentioning

confidence: 99%

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LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis

Duan

Zhang

2023

Korean Circ J

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Author's summary Lysyl oxidase like 1 antisense RNA 1 (LOXL1-AS1) promoted hypoxia/reoxygenation (H/R)-induced pyroptosis in cardiomyocyte. MiR-761 inhibited H/R-induced pyroptosis in cardiomyocyte. LOXL1-AS1 targeted miR-761 and miR-761 targeted phosphatase and tensin homolog. LOXL1-AS1 induced cardiomyocyte pyroptosis by targeting miR-761 under H/R conditions. LOXL1-AS1 enhanced myocardial ischemia and reperfusion injury in vivo.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis

Duan

Zhang

2023

Korean Circ J

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“…Studies have shown that serum in ammatory marker C-reactive protein (CRP) can predict the instability of coronary atherosclerotic plaque and is proportional to the incidence and severity of cardiovascular disease [23]. In addition, oxidized low-density lipoprotein (ox-LDL) degrades the brous cap of coronary atherosclerosis and increases plaque instability, and studies have shown that elevated levels of cholesterol and ox-LDL are the main causes of atherosclerosis [24]. To further verify the above views, we also focused on measuring CRP, ox-LDL, cholesterol and other indicators of CAD patients.…”

Section: Discussionmentioning

confidence: 99%

Changes in IL-27 and its effect on CD4 + T cells in patients with coronary artery disease

Cai

Tang

et al. 2022

Preprint

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Objective：Coronary artery disease (CAD) is an immune-mediated chronic disease, and interleukin-27(IL-27) regulates CD4+ T cell differentiation. However, little is known about its effects on CAD. Therefore, we aimed to investigate the changes of IL-27 and its effect on CD4+ T cells in patients with CAD.Methods: The severity of coronary artery stenosis was assessed by Gensini score, and the concentrations of plasma IL-27, ox-LDL were measured by ELISA. qRT-PCR and Western Blotting (WB) were performed to evaluate the mRNA and protein expression of T-bet, IFN-γ, GATA-3, and RORγt. After monocytes were stimulated with recombinant IL-2 and/or IL-27, CD4+IFN-γ+T cells, CD4+IL-4+T cells, CD4+IL-17+T cells, CD4+LAP+T cells and CD4+CD25+Foxp3+ Tregs were counted by flow cytometry. Results: Plasma IL-27 levels were significantly elevated in patients with Acute Coronary Syndromes (ACS). IL-27 levels were positively correlated with ox-LDL and Gensini scores (P < 0.01) and ox-LDL levels were positively correlated with Gensini scores (P < 0.01). The more severe the stenosis in CAD patients, the more Th1 and Th17 cells, and the less Th2, CD4+CD25+Foxp3+Tregs and CD4+LAP+T cells. IL-27 can increase the expression of T-bet and IFN-γ, and inhibit the expression of RORγt and GATA-3, and finally promote the differentiation of CD4+T cells into Th1 cells, and inhibit the differentiation of Th2, Th17, CD4+CD25+Foxp3+Tregs and CD4+LAP+T cells.Conclusion: IL-27 regulates CAD by increasing the expression of T-bet and IFN-γ and inhibiting the expression of RORγt and GATA-3, thereby increasing the frequency of Th1 cells and decreasing the frequency of Th2, Th17, CD4+CD25+Foxp3+Tregs and CD4+LAP+T cells.

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Elucidating thoracic aortic dissection pathogenesis: The interplay of m1A-related gene expressions and miR-16-5p/YTHDC1 Axis in NLRP3-dependent pyroptosis

Liu,

Li,

Yin

et al. 2024

International Journal of Biological Macromolecules

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RETRACTED ARTICLE: Differential Expression of LOXL1-AS1 in Coronary Heart Disease and its Regulatory Mechanism in ox-LDL-Induced Human Coronary Artery Endothelial Cell Pyroptosis

Cited by 5 publications

References 27 publications

LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis

LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis

Changes in IL-27 and its effect on CD4 + T cells in patients with coronary artery disease

Elucidating thoracic aortic dissection pathogenesis: The interplay of m1A-related gene expressions and miR-16-5p/YTHDC1 Axis in NLRP3-dependent pyroptosis

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