LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis

Abstract

Author's summary Lysyl oxidase like 1 antisense RNA 1 (LOXL1-AS1) promoted hypoxia/reoxygenation (H/R)-induced pyroptosis in cardiomyocyte. MiR-761 inhibited H/R-induced pyroptosis in cardiomyocyte. LOXL1-AS1 targeted miR-761 and miR-761 targeted phosphatase and tensin homolog. LOXL1-AS1 induced cardiomyocyte pyroptosis by targeting miR-761 under H/R conditions. LOXL1-AS1 enhanced myocardial ischemia and reperfusion injury in vivo.

Determination of the Protective Impact of Hypericum perforatum Extract Against Ovarian Ischemia and Reperfusion in Rats

“…Another study, in which cardiac ischemia reperfusion was searched, reported that mTOR and Akt values in I/R group were found higher than that of the sham group (28). He et al (29) found that PTEN was highly expressed after I/R when they studied on human cardiomyocyte. In our study, PTEN, Akt and mTOR levels showed the significant difference between groups but not PI3K level (P>0.05).…”

LOXL1-AS1/miR-761/PTEN as a Novel Signaling Pathway in Myocardial Ischemia and Reperfusion Injury (MIRI): Epigenetic Regulation by Long Non-Coding RNA (LncRNA) in MIRI

“…First, the authors confirmed that LOXL1-AS1 was highly expressed under hypoxia/reoxygenation conditions. 10) This increased LOXL1-AS1 negatively regulated miR-761 level the as a molecular sponge. In addition, the authors also confirmed that miR-761 downregulates the mRNA level of PTEN.…”

“…In this issue of the Korean Circulation Journal , He et al 10) investigated the LOXL1-AS1 play a key epigenetic regulator in cardiomyocyte pyroptosis in MIRI. The authors proposed LOXL1-AS1/miR-761/PTEN as a novel signaling pathway affecting pyroptosis in MIRI.…”

“…Finally, the authors found that the LOXL1-AS1/miR-761/PTEN signaling axis was also applied in an in vivo ischemia/reperfusion (I/R) mouse model. 10) …”

“…In addition, LOXL1-AS1 and miR-761 were proposed as new targets for future MIRI therapeutics by linking in vitro results using human cardiomyocyte with in vivo experimental results using I/R model mice. 10) …”