Differential Expression of Interphotoreceptor Retinoid-binding Protein, Opsin, Cellular Retinaldehyde-binding Protein, and Basic Fibroblastic Growth Factor

Gonzalez‐Fernandez, Federico; Niel, E. Van; Edmonds, C. J.; Beaver, Hilary A.; Nickerson, John M.; Garcı́a-Fernández, José Manuel; Campohiaro, P. A.; Foster, RG

doi:10.1006/exer.1993.1055

Cited by 31 publications

(21 citation statements)

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“…Mouse IRBP mRNA is present at E11 (Liou et al, 1994), whereas IRBP protein is not detected until E17 (Carter-Dawson et al, 1986). Although the onset of IRBP synthesis in the embryonic rat retina has not been reported, IRBP mRNA is present at P0 in developing photoreceptors (Gonzalez-Fernandez et al, 1993), but the protein is first evident between P2 (Eisenfeld et al, 1985) and P5 (Gonzalez-Fernandez et al, 1993).…”

Section: Discussionmentioning

confidence: 95%

SPACRCAN in the developing retina and pineal gland of the rat: Spatial and temporal pattern of gene expression and protein synthesis

Foletta

Nishiyama

Rayborn

et al. 2001

J of Comparative Neurology

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SPACRCAN is a hyaluronan-binding proteoglycan that is present in the pineal gland and interphotoreceptor matrix of the retina. Here, we evaluate the pattern of SPACRCAN gene expression and protein appearance during retinal and pineal gland development in the rat. In situ hybridization histochemistry with SPACRCAN riboprobes indicates that hybridization signals are first evident in the retina over developing photoreceptor cells at embryonic day 16 (E16) and in the pineal gland at E21. Immunocytochemistry using a SPACRCAN antibody shows localization of SPACRCAN protein in the developing interphotoreceptor matrix by Postnatal day 5 (P5) and in the pineal gland by P6. These studies suggest that SPACRCAN mRNA expression may occur substantially earlier than the time when SPACRCAN protein is detectable in both the retina and the pineal gland. The period of retinal histogenesis when SPACRCAN is detected first is coincident with the time photoreceptors begin to extend from the outer retinal surface, suggesting that SPACRCAN may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment.

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Section: Discussionmentioning

confidence: 95%

SPACRCAN in the developing retina and pineal gland of the rat: Spatial and temporal pattern of gene expression and protein synthesis

Foletta

Nishiyama

Rayborn

et al. 2001

J of Comparative Neurology

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“…During the development of the human (Johnson et al, 19851, bovine (Hauswirth et al, 19921, and rodent (Eisenfeld et al, 1985;Carter-Dawson et al, 1986;GonzalezFernandez and Healy, 1990;Gonzalez-Fernandez et al, 1993b;Liou et al, 1994) retina, IRBP expression is upregulated early during retinal differentiation. In contrast to the rodent retina, the developingxenopus retina does not show a significant difference in the overall levels of IRBP and opsin mRNAs extracted from whole embryos (GonzalezFernandez et al, 1993a).…”

Section: Discussionmentioning

confidence: 95%

“…In addition, the gene for IRBP is upregulated before that of opsin (Gonzalez-Fernandez and Healy, 1990;DesJardin et al, 1993;Gonzalez-Fernandez et al, 1993b;Liou et al, 1994). However, a definite difference in the temporal expression of the m R N h for IRBP and opsin is not observed in Xenopus when Northern blots are done on RNA extracted from whole embryos (Gonzalez-Fernandez et al, 1993a).…”

mentioning

confidence: 92%

“…The fact that IRBP accumulates in the interphotoreceptor matrix before it is needed for 11-cis retinallall-trans retinol exchange during the visual cycle (Eisenfeld, et al, 1985;Johnson et al, 1985;Carter-Dawson et al, 1986;Hauswirth et al, 1992;Gonzalez-Fernandez et al, 1993b) suggests the possibility that IRBP plays a role in developmental interactions between the pigment epithelium and neural retina. In addition, the gene for IRBP is upregulated before that of opsin (Gonzalez-Fernandez and Healy, 1990;DesJardin et al, 1993;Gonzalez-Fernandez et al, 1993b;Liou et al, 1994).…”

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confidence: 96%

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Interphotoreceptor retinoid-binding protein (IRBP): Expression in the adult and developingXenopus retina

et al. 1996

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Apposition of the neural retina and pigment epithelium is critical to photoreceptor development and function. Interphotoreceptor retinoid-binding protein (IRBP) is a major component of the extracellular matrix separating these epithelia in the African clawed frog Xenopus laevis (Gonzalez-Fernandez et al., [1993], J. Cell Sci. 105:7-21). In the adult retina, IRBP appears to mediate the transport of hydrophobic molecules, particularly retinoids and fatty acids, within the hydrophilic extracellular domain. In this paper, we compare the distribution of IRBP and its mRNA in adult and embryonic Xenopus retina. Xenopus IRBP antisense RNA, labeled with tritium or digoxigenin, was used for in situ hybridizaton studies. For immunohistochemistry, we used an antiserum against Xenopus IRBP expressed in Escherichia coli. In the adult, we found that IRBP is synthesized at similar levels by both rods and cones. The protein is restricted to the interphotoreceptor matrix, with lesser amounts in the pigment epithelial cytoplasm. In the embryo, expression of the mRNA for IRBP is restricted to the central retina, where photoreceptor differentiation has taken place. By contrast, the protein is distributed throughout the embryonic subretinal space. Therefore, the presence of IRBP precedes photoreceptor differentiation. In summary, IRBP is synthesized by both rods and cones and may be internalized by the pigment epithelium. In the embryo, IRBP is synthesized by the central retina and diffuses through the matrix, reaching the undifferentiated peripheral retina. In view of its ligand-binding properties, diffusion of IRBP may provide the peripheral neural retina with a vehicle to transport retinoids and docosahexaenoic acid (molecules critical to normal retinal development) from the pigment epithelium.

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“…Microscopic techniques in the 19th century allowed for the discovery of glioma-like features in some cases, thus inspiring Virchow [23] to coin the term “glioma of the retina.” In the later part of the century, Flexner [24] and Wintersteiner [25] separately observed that photoreceptor-like rosettes were frequently present in tumor sections, and re-named the tumor “neuroepithelioma.” Given the coexistence of glial and neuronal cell types from a common retinal precursor, Verhoeff and Jackson [26] suggested that the term “retinoblastoma” be used, and this name was officially adopted at the 1926 American Ophthalmological Society meeting. Later techniques, including electron microscopy and immunohistochemistry, have given further credence to the name “retinoblastoma” by confirming that the tumor is of retinal precursor cell origin, and has the potential to remain in an undifferentiated state or to differentiate into photoreceptor-like cells [27,28,29,30,31,32,33,34]. …”

mentioning

confidence: 99%

Retinal Reactive Astrocytic Tumor (Focal Nodular Gliosis): The Entity Also Known as Vasoproliferative Tumor

Grossniklaus

Lenis²

2017

Ocul Oncol Pathol

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Differential Expression of Interphotoreceptor Retinoid-binding Protein, Opsin, Cellular Retinaldehyde-binding Protein, and Basic Fibroblastic Growth Factor

Cited by 31 publications

References 0 publications

SPACRCAN in the developing retina and pineal gland of the rat: Spatial and temporal pattern of gene expression and protein synthesis

SPACRCAN in the developing retina and pineal gland of the rat: Spatial and temporal pattern of gene expression and protein synthesis

Interphotoreceptor retinoid-binding protein (IRBP): Expression in the adult and developingXenopus retina

Retinal Reactive Astrocytic Tumor (Focal Nodular Gliosis): The Entity Also Known as Vasoproliferative Tumor

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