Retinal Reactive Astrocytic Tumor (Focal Nodular Gliosis): The Entity Also Known as Vasoproliferative Tumor

Grossniklaus, Hans E.; Lenis, Tamara L.

doi:10.1159/000455149

Cited by 5 publications

(4 citation statements)

References 24 publications

(35 reference statements)

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“…A boy with congenital unilateral microphthalmos presented with an orbital mass with histologic features of pilocytic astrocytoma and/or retinal gliosis. Using light microscopy, low-grade intraocular astrocytoma is indistinguishable from massive retinal gliosis 1, 2, 3, 4…”

Section: Discussionmentioning

confidence: 99%

Orbital tumor associated with a microphthalmic eye and colobomatous cleft: Pilocytic astrocytoma (glioma) or massive retinal gliosis

Ginderdeuren

Sciot

Mombaerts

2018

Saudi Journal of Ophthalmology

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A 11-year-old boy with congenital microphthalmos of the right eye presented with gradual protrusion of his ocular prosthesis. MRI showed an orbital mass adjacent to the microphthalmic eye. After removal of the eye and the orbital soft tissue mass a gliotic mass, resembling a pilocytic astrocytoma WHO grade 1 (glioma) was diagnosed. Through a colobomatous cleft in the eye the tumour spread in the orbit. There were no clinical signs of neurofibromatosis 1. This case showed a very rare association between a microphthalmic and colobomatous eye and pilocytic astrocytoma, grade 1. However a far advanced and infiltrative massive retinal gliosis cannot be definitively excluded as differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Orbital tumor associated with a microphthalmic eye and colobomatous cleft: Pilocytic astrocytoma (glioma) or massive retinal gliosis

Ginderdeuren

Sciot

Mombaerts

2018

Saudi Journal of Ophthalmology

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“…Some vessels appear to be occluded by a thrombus. 1,3 Although inflammatory diseases are assumed to be associated with secondary VPT/RRAT, to our knowledge, it has not been revealed histopathologically previously. Therefore, analysis of the histopathological assessment of secondary VPT/RRAT associated with intraocular inflammation should help understand the pathologic fiindings.…”

mentioning

confidence: 87%

Clinicopathological Analysis of Secondary Retinal Vasoproliferative Tumor/Reactive Retinal Astrocytic Tumor Successfully Treated by Endoresection

Hashimoto

Takase

Kase

et al. 2024

RETINAL Cases &Amp; Brief Reports

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In the case of secondary vasoproliferative tumor/reactive retinal astrocytic tumor, tumor resection and clinicopathological analysis on the excised tissue were performed. The results showed that endoresection could be an effective treatment option for secondary vasoproliferative tumor/reactive retinal astrocytic tumor accompanied by retinal vasculitis. Furthermore, the pathologic findings revealed that inflammatory cells infiltrate the tissue in secondary vasoproliferative tumor/reactive retinal astrocytic tumor.

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“…Interestingly, it is well known by now that this tumour is, unlike the current name suggests, less of vascular origin but rather a glial/astrocytic mass. Following this knowledge, current suggestions aim at re‐naming this entity to ‘reactive retinal astrocytic tumour’ or ‘focal nodular gliosis’ (Grossniklaus et al 2017). However, as VPT is still the most commonly used term for this entity, we will continue to name this entity as VPT in this report.…”

Section: Introductionmentioning

confidence: 99%

Robotic‐assisted radiosurgery for the treatment of vasoproliferative tumours

Schmelter

Fuerweger

Muacevic³

et al. 2020

Acta Ophthalmologica

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Purpose Vasoproliferative tumours (VPT) are a rare but benign entity that can lead to severe visual acuity deterioration. There is no standard of care, and depending on the degree of clinical features, including tumour size and dissemination, visual acuity and subretinal fluid, treatment options include observation, cryotherapy and brachytherapy. Particularly in larger tumours, brachytherapy has advantages over other options, although higher radiation doses and the need for surgical application are disadvantages of this otherwise effective treatment option. CyberKnife radiosurgery might represent an alternative therapeutic option as no surgical intervention is needed and radiation doses are lower. Methods All patients diagnosed with vasoproliferative tumors who were treated with CyberKnife radiosurgery with a minimum follow‐up time of 12 months were included in this case series. We recorded visual acuity, number of lesions, central retinal thickness with optical coherence tomography (OCT) and reflectivity using A‐scan standardizes echography every three months. Results A total of four patients with a median age of 34 years (range: 24 – 51) who were observed over an average of 26.5 months (range: 17 – 49 months) matched our inclusion criteria. We appreciated stabilization or increase in visual acuity in all four patients and a regression in tumour thickness with subsequent increase in internal reflectivity as a marker of increasing fibrosis. Conclusion We observed good visual and functional outcome following CyberKnife therapy for VPT. We believe that further studies should be pursued to evaluate CyberKnife therapy for the treatment of VPT not treatable with cryo‐ or lasertherapy.

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Retinal Reactive Astrocytic Tumor (Focal Nodular Gliosis): The Entity Also Known as Vasoproliferative Tumor

Cited by 5 publications

References 24 publications

Orbital tumor associated with a microphthalmic eye and colobomatous cleft: Pilocytic astrocytoma (glioma) or massive retinal gliosis

Orbital tumor associated with a microphthalmic eye and colobomatous cleft: Pilocytic astrocytoma (glioma) or massive retinal gliosis

Clinicopathological Analysis of Secondary Retinal Vasoproliferative Tumor/Reactive Retinal Astrocytic Tumor Successfully Treated by Endoresection

Robotic‐assisted radiosurgery for the treatment of vasoproliferative tumours

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