Differential Expression of ErbB3 and ErbB4 Neuregulin Receptors in Dopamine Neurons and Forebrain Areas of the Adult Rat

Steiner, Heinz; Blum, Mariann; Kitai, S.T.; Fedi, Paolo

doi:10.1006/exnr.1999.7163

Cited by 99 publications

(92 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…291 In adult rodent brain Erbb3 mRNA, with prominence mainly in white matter, has an expression pattern different from that of Erbb4. 34,292,293 While Erbb3 mRNA was expressed in the ventral and dorsal spinal cord roots of fetal rats, it was absent from these areas in adults. It re-appeared after ventral funiculus lesion; a role for Erbb3 in regenerative growth of axons was suggested.…”

Section: Hematopoietic Neoplasmsmentioning

confidence: 99%

The ERBB3 receptor in cancer and cancer gene therapy

2008

View full text Add to dashboard Cite

ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other ERBB and nonERBB receptors as well as by other kinases, and by novel mechanisms. Downstream it interacts prominently with the phosphoinositol 3-kinase/AKT survival/mitogenic pathway, but also with GRB, SHC, SRC, ABL, rasGAP, SYK and the transcription regulator EBP1. There are likely important but poorly understood roles for nuclear localization and for secreted isoforms. Studies of ERBB3 expression in primary cancers and of its mechanistic contributions in cultured cells have implicated it, with varying degrees of certainty, with causation or sustenance of cancers of the breast, ovary, prostate, certain brain cells, retina, melanocytes, colon, pancreas, stomach, oral cavity and lung. Recent results link high ERBB3 activity with escape from therapy targeting other ERBBs in lung and breast cancers. Thus a wide and centrally important role for ERBB3 in cancer is becoming increasingly apparent. Several approaches for targeting ERBB3 in cancers have been tested or proposed. Small inhibitory RNA (siRNA) to ERBB3 or AKT is showing promise as a therapeutic approach to treatment of lung adenocarcinoma.

show abstract

Section: Hematopoietic Neoplasmsmentioning

confidence: 99%

The ERBB3 receptor in cancer and cancer gene therapy

2008

View full text Add to dashboard Cite

show abstract

“…The downregulated genes were myelin and lymphocyte protein found in chromosome 2qcen-13, 2 0 ,3 0 -cyclic nucleotide 3 0 phosphodiesterase (CNP) in chromosome 17q21, myelin-associated glycoprotein (MAG) in chromosome 19q13.1, transferring in chromosome 3q21, gelsolin in chromosome 9q33-34, and the v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (also known as HER3), a neuregulin receptor (96). As mentioned before, NRG1 has a key role in neuronal migration and specification, 104,105 GABA and glutamate receptor expression 106 and in synaptogenesis and synaptic plasticity in the CNS. 107 Further, it shows trophic and mitogenic effects in oligodendrocyte progenitor cell (OPC) cells in vitro.…”

Section: Oligodendrocyte-related Genes Associated With Schizophreniamentioning

confidence: 99%

The myelin-pathogenesis puzzle in schizophrenia: a literature review

2007

View full text Add to dashboard Cite

Schizophrenia is a serious and disabling mental disorder with symptoms such as auditory hallucinations, disordered thinking and delusions, avolition, anhedonia, blunted affect and apathy. In this review article we seek to present the current scientific findings from linkage studies and susceptible genes and the pathophysiology of white matter in schizophrenia. The article has been reviewed in two parts. The first part deals with the linkage studies and susceptible genes in schizophrenia in order to have a clear-cut picture of the involvement of chromosomes and their genes in schizophrenia. The genetic linkage results seem to be replicated in some cases but in others are not. From these results, we cannot draw a fine map to a single locus or gene, leading to the conclusion that schizophrenia is not caused by a single factor/gene. In the second part of the article we present the oligodendrocyte-related genes that are associated with schizophrenia, as we hypothesize a potential role of oligodendrocyte-related genes in the pathology of the disorder.

show abstract

“…[8][9][10][11] ERBB4 plays a critical role in the development of the brain, and has been shown to directly influence the proliferation, organization and migration of cells in the rostral migratory stream. [12][13][14] There is now emerging evidence that the gene for ERBB4 also influences risk for schizophrenia, 15,16 especially when considered together with NRG1. 16 Moreover, there is evidence from postmortem mRNA studies for alterations in the levels of ERBB4 15 (as well as the ERBB3 coreceptor [17][18][19][20][21] ) in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene

et al. 2007

View full text Add to dashboard Cite

Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact with ERBB4, to identify genes and pathways that might contribute to schizophrenia susceptibility. We identified the MAGI scaffolding proteins as ERBB4-binding proteins. After validating the interaction of MAGI proteins with ERBB4 in mammalian cells, we demonstrated that ERBB4 expression, alone or in combination with ERBB2 or ERBB3, led to the tyrosine phosphorylation of MAGI proteins, and that this could be further enhanced with receptor activation by neuregulin. As MAGI proteins were previously shown to interact with receptor phosphotyrosine phosphatase b/f (RPTPb), we postulated that simultaneous binding of MAGI proteins to RPTPb and ERBB4 forms a phosphotyrosine kinase/phosphotyrosine phosphatase complex. Studies in cultured cells confirmed both a spatial and functional association between ERBB4, MAGI and RPTPb. Given the evidence for this functional association, we examined the genes coding for MAGI and RPTPb for genetic association with schizophrenia in a Caucasian United Kingdom case-control cohort (n = B1400). PTPRZ1, which codes for RPTPb, showed significant, gene-wide and hypothesis-wide association with schizophrenia in our study (best individual single-nucleotide polymorphism allelic P = 0.0003; gene-wide P = 0.0064; hypothesiswide P = 0.026). The data provide evidence for a role of PTPRZ1, and for RPTPb signaling abnormalities, in the etiology of schizophrenia. Furthermore, the data indicate a role for RPTPb in the modulation of ERBB4 signaling that may in turn provide further support for an important role of neuregulin/ERBB4 signaling in the molecular basis of schizophrenia.

show abstract

Differential Expression of ErbB3 and ErbB4 Neuregulin Receptors in Dopamine Neurons and Forebrain Areas of the Adult Rat

Cited by 99 publications

References 73 publications

The ERBB3 receptor in cancer and cancer gene therapy

The ERBB3 receptor in cancer and cancer gene therapy

The myelin-pathogenesis puzzle in schizophrenia: a literature review

Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene

Contact Info

Product

Resources

About