Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors

Tenório, Jefferson da Rocha; Silva, Leorik Pereira da; Xavier, Marília Gabriela De Aguiar; Santana, Thalita; Nascimento, George João Ferreira do; Sobral, Ana Paula Veras

doi:10.1007/s00405-018-5058-5

Cited by 5 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 15 , 30 Furthermore, this prominent diffuse distribution in pleomorphic adenoma demonstrates the role of cyclin D1 in the rapidly expanding growth of even benign-looking tumors. High mixed nuclear and cytoplasmic intracellular localization was seen in pleomorphic adenoma, similar to the study of Tenorio et al 14 …”

Section: Discussionsupporting

confidence: 88%

“…All studied benign salivary tumors expressed cyclin D1 (100%), frequently showed diffuse scoring and were most commonly detected in pleomorphic adenoma. Another study by Tenorio et al 14 revealed only 60.5% positivity with mild scoring of pleomorphic adenoma. On the other hand, Jour et al 15 study displayed cyclin D1 expression in 93% of benign tumors, with predominant moderate scoring in both pleomorphic adenoma and warthin tumors.…”

Section: Discussionmentioning

confidence: 88%

“…Literature showed conflicting results regarding cyclin D1 expression in benign and malignant salivary tumors. 14–16 This study aimed to examine the expression of both syndecan-1 and cyclin D1 in different salivary tumors to investigate the biological behaviors of these tumors from clinicopathological, and relate the expression of these markers to available clinicopathological parameters.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Expression of Syndecan-1 and Cyclin D1 in Salivary Gland Tumors in Relation to Clinicopathological Parameters

Mohammad¹,

Ibraheem²,

Khudair³

et al. 2023

IJGM

View full text Add to dashboard Cite

Background Salivary tumors have various morphological features and might share some histopathological findings. They are considered a problematic area in diagnosis due to complex clinicopathological features and different biological behavior. Objective To identify the pathological behavior of salivary tumors immunohistochemically. Methodology This retrospective study involved thirty formalin-fixed paraffin-embedded blocks of salivary gland tumors. These tumors were stained immunohistochemically with syndecan-1 and cyclin D1. Chi-Square test was used to relate immunoscoring, intracellular localization, intensity, and invasion to different salivary tumors. The correlation of these two markers was done by spearman‘s rho test. P-value <0.05 was considered statistically significant. Results The mean age of the patients was 48.69 ± 17.7. The parotid gland was the most commonly reported site in benign tumors, and regarding malignant tumors, maxilla was the most prevalent site. Syndecan-1 in benign tumors showed a predominate score 3, most widely detected in pleomorphic adenoma. Malignant salivary tumors showed 89.4% positive expression with a more frequent score 3, most commonly found in adenocystic carcinoma. Cyclin D1 expressed in all benign salivary tumors, with prominent diffuse mixed intracellular localization in pleomorphic adenoma. Malignant tumors revealed an expression of 94.7%. Moderate scoring with mixed intracellular localization was recorded in adenocystic carcinoma, followed by mucoepidermoid carcinoma. There was a significant correlation between the two markers in response to the distribution of immunostaining in different cell compartments. Conclusion Syndecan-1 and cyclin D1 showed a significant combined role in salivary tumor progression. Interestingly notable ductal-myoepithelial cells affect epithelial morphogenesis, and growth of pleomorphic adenoma was observed. Furthermore, basophilic cells of cribriform adenocystic carcinomas might control the aggressiveness and proliferation rate of these tumors.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of Syndecan-1 and Cyclin D1 in Salivary Gland Tumors in Relation to Clinicopathological Parameters

Mohammad¹,

Ibraheem²,

Khudair³

et al. 2023

IJGM

View full text Add to dashboard Cite

show abstract

“…Interestingly, Sakurai et al found that the expression of COX-2 was group-dependent and increased from the normal salivary glands, to the salivary gland adenomas, with the highest expression detected in the salivary gland carcinoma group [31]. Furthermore, two studies found that the level of COX-2 in mucoepidermoid carcinoma (MEC) was strongly increased, whereas most of the pleomorphic adenomas and adenoid cystic carcinomas (AdCC) were COX-2-negative [46,47]. In melanomas, Nascimento et al found that oral melanomas were consistently COX-2-positive compared with the benign oral nevi, which were completely COX-2-negative [48].…”

Section: Cox-2 Expression In Other Head and Neck Tumorsmentioning

confidence: 99%

Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis

Frejborg

Salo

Salem

2020

IJMS

View full text Add to dashboard Cite

The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progression of head and neck cancers (HNC). COX-2 can mediate its protumorigenic effect through various mechanisms, such as inducing cell proliferation, inhibition of apoptosis, and suppressing the host’s immune response. Furthermore, COX-2 can induce the production of vascular endothelial growth factors, hence, promoting angiogenesis. Indeed, the ability of COX-2 inhibitors to selectively restrict the proliferation of tumor cells and mediating apoptosis provides promising therapeutic targets for cancer patients. Thus, in this comprehensive review, we summarized the reported differential expression patterns of COX-2 in different stages of head and neck carcinogenesis—from potentially premalignant lesions to invasive carcinomas. Furthermore, we examined the available meta-analysis evidence for COX-2 role in the carcinogenesis of HNC. Finally, further understanding of the biological processes of COX-2 and its role in orchestrating cell proliferation, apoptosis, and angiogenesis may give therapeutically beneficial insight to develop the management plan of HNC patients and improve their clinical outcomes.

show abstract

“…Our previous study has demonstrated that the expression of cyclin D1 was upregulated in AdCC when compared with PMA and/or NSG (Bu et al., 2015). In addition, the expression of cyclin D1 is upregulated in MEC and plays an important role in the Wnt‐signaling pathway to produce poor prognosis and poorly differentiated tumor staging of MEC (Shiratsuchi et al., 2007; Tenorio et al, 2018). In this study, we found that SIX1 and AP2M1 were correlated with cyclin D1, so we can propose a hypothesis that SIX1 and AP2M1 play an important role in AdCC and MEC proliferation similar to that of cyclin D1.…”

Section: Discussionmentioning

confidence: 99%

Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma

Xiao

et al. 2020

Oral Diseases

View full text Add to dashboard Cite

Objective: Adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma (MEC) are the most frequent malignancies in the salivary glands. The purpose of this study was to explore the roles of sine oculis homeobox homolog 1 (SIX1), malic enzyme 2 (ME2), and AP-2 complex subunit mu (AP2M1) in AdCC and MEC, as well as the potential relationship between SIX1, ME2, AP2M1, and proliferation marker cyclin D1. Material and methods: Immunohistochemistry was performed on human salivary gland tissue microarrays that contained 76 normal salivary glands (NSGs), 14 pleomorphic adenomas (PMAs), 81 AdCCs, and 52 MECs. Results: We observed that the expression levels of SIX1 and ME2 were significantly elevated in AdCC and MEC when compared with NSG and PMA. In addition, we detected that AP2M1 was overexpressed in AdCC and MEC when compared with NSG. We also found that SIX1 and AP2M1 were positively associated with cyclin D1. Conclusions: These results may prove that SIX1 and AP2M1 are involved in the proliferation of AdCC and MEC to cause tumor growth. K E Y W O R D S adenoid cystic carcinoma, AP-2 complex subunit mu, malic enzyme 2, mucoepidermoid carcinoma, sine oculis homeobox homolog 1

show abstract

Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors

Abstract: The overexpression of COX-2, observed only in MEC, emphasizes that salivary gland tumors have different profiles. Cyclin D1 is more immunoexpressed in malignant tumors. Together, these immunohistochemical findings may be useful in differentiating the studied tumors.

Cited by 5 publications

References 28 publications

Expression of Syndecan-1 and Cyclin D1 in Salivary Gland Tumors in Relation to Clinicopathological Parameters

Expression of Syndecan-1 and Cyclin D1 in Salivary Gland Tumors in Relation to Clinicopathological Parameters

Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis

Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma

Contact Info

Product

Resources

About