Differential efficacy of mebendazole and albendazole againstNecator americanus but not forTrichuris trichiura infestations

Hölzer, Bodo; Frey, F J

doi:10.1007/bf02456002

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…This may indicate that the duration of exposure of the parasite to mebendazole rather than the concentration of the drug in the bowel is important for efficacy. However, as shown by Holzer and Frey [64], this was not the case for albendazole.…”

Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 88%

Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 99%

“…Increasing the single dose of albendazole to 600 mg and 800 mg did not significantly alter the cure rate of the drug [47,48,64]. Increasing the dose of mebendazole to 1.0 g also seemed not to improve the cure rate against hookworm infections [64]. These results are in contrast to those of Cauwenberg [88] that showed that increasing the single dose of mebendazole from 200 mg to 500 mg and to 600 mg yielded cure rates of 8%, 54% and 78%, respectively.…”

Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 99%

“…The reason for the difference in the clinical efficacy of mebendazole and albendazole is not very clear [64]. It may be due to the different pharmacokinetic properties of the two drugs.…”

Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 99%

“…Previous data by Cabrera[62] described a cure rate of 88.2% after mebendazole was given as a 600 mg single dose[63]. While the latter result may imply that a higher dose of the drug even when administered as a single dose is more effective, Holzer and Frey[64] have reported that a single 1.0 g oral dose of mebendazole cured only 21% of patients infected with N. americanus.…”

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confidence: 98%

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Necatoriasis: treatment and developmental therapeutics

Georgiev¹

2000

Expert Opinion on Investigational Drugs

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Two hookworm parasites, Necator americanus and Ancylostoma duodenale, infect approximately one billion people worldwide. These hookworms are one of the leading causes of iron-deficiency anaemia especially in children, resulting directly from intestinal capillary blood loss following the feeding activities of fourth-stage (L(4)) larva and adult worms. If ignored, human hookworm infections can retard growth and the intellectual development of children. Another clinical manifestation often associated with hookworm infections is cutaneous larva migrans (CLM). It is a well recognised, usually self-limiting condition caused by the infectious larvae of nematodes, especially Ancylostoma spp. CLM is characterised by skin eruption and represents a clinical description rather than a definitive diagnosis. Of the hookworm parasites, the dog and cat worm A. braziliense and A. caninum are the most common nematodes causing CLM, although many other species have also been implicated. The major subject of this review article will be discussion of the evolution of therapies and treatment of human necatoriasis and the development of experimental infections with N. americanus. Difference in the clinical efficacy of mebendazole and albendazole will be discussed along with drug resistance of N. americanus.

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Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 88%

Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 99%

Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 99%

“…The reason for the difference in the clinical efficacy of mebendazole and albendazole is not very clear [64]. It may be due to the different pharmacokinetic properties of the two drugs.…”

Section: Differential Efficacies Of Mebendazole and Albendazolementioning

confidence: 99%

mentioning

confidence: 98%

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Necatoriasis: treatment and developmental therapeutics

Georgiev¹

2000

Expert Opinion on Investigational Drugs

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A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris and hookworm infections

Albonico

Smith

Hall

et al. 1994

Transactions of the Royal Society of Tropical Medicine and Hygi

125

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The efficacies and side effects of single dose treatments with 500 mg mebendazole (Janssen Pharmaceutica) and 400 mg albendazole (SmithKline Beecham) against intestinal nematodes were compared in a single-blind, randomized controlled trial among 2294 children aged 6 to 12 years on Pemba Island, Zanzibar, among whom infections with Ascaris, hookworms and Trichuris were highly prevalent. Both drugs were highly effective against Ascaris, with cure rates of over 97%. The cure rates for Trichuris were low, but mebendazole was significantly better than albendazole and produced a greater reduction in the geometric mean egg count. Mebendazole was inferior to albendazole in curing hookworm infections and in reducing the geometric mean egg count. There was no difference in the frequency of side effects reported by heavily infected children treated with either drug. In a trial on 402 children, 500 mg mebendazole (Janssen) was compared with a generic version of the drug, 500 mg mebendazole (Pharmamed). No difference was apparent in the efficacies of the 2 treatments against any of the 3 parasites studied.

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