Necatoriasis: treatment and developmental therapeutics

Georgiev, Vassil St.

doi:10.1517/13543784.9.5.1065

Cited by 15 publications

(5 citation statements)

References 99 publications

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“…More samples were positive by conventional microscopy than by PCR. This may be attributed to the greater chance of false positive results by microscopy due to the near identical morphology of A. caninum eggs to those of other hookworms such as Ancylostoma duodenale and Ancylostoma braziliense (Georgiev 2000).…”

Section: Discussionmentioning

confidence: 99%

First report of the molecular detection of Ancylostoma caninum in Lahore, Pakistan: the threat from pets

Rehman¹,

Akhtar²,

Akbar³

et al. 2017

Vet. Med. - Czech

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ABSTRACT:The molecular prevalence of Ancylostoma caninum was determined in stray and pet dogs in Lahore, Pakistan from July 2014 to August 2015. A total of 500 dog faecal samples were first evaluated using a sedimentation technique and further through a PCR assay targeting the ITS-2 region of the A. caninum genome. Overall, 130 (26%) samples were positive for hookworm infestation by microscopic examination. Only microscopically positive samples were processed for PCR and 89 (17.6%) were positive for A. caninum. Sequence analysis of amplicons showed 100% homology with A. caninum and the genotypes clustered in one clade with Brazilian A. caninum hookworms. There was a significantly (P < 0.05) increased prevalence in male dogs younger than six months old. Labrador retrievers had higher A. caninum incidence compared to German shepherds and other breeds. To the best of our knowledge, this is the first report of the molecular prevalence of A. caninum in dogs in Pakistan. The novel results of the present study allow us to conclude that A. caninum is more prevalent in pet dogs, especially puppies, and this can be a potential threat for humans that come into contact with such animals. Therefore, the routine monitoring of pets, especially the more susceptible breeds, is essential for disease control.

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Section: Discussionmentioning

confidence: 99%

First report of the molecular detection of Ancylostoma caninum in Lahore, Pakistan: the threat from pets

Rehman¹,

Akhtar²,

Akbar³

et al. 2017

Vet. Med. - Czech

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“…Despite potential safety concerns (cutaneous larva migrans and/or Loffler's syndrome or other pulmonary complications [ 323 , 324 ] about this approach, the experimental infection of a small number of human subjects has been surprisingly safe [ 321 , 325 ].…”

Section: Other Modulators Of the Th1/th2 Balance In Asthmamentioning

confidence: 99%

New drugs targeting Th2 lymphocytes in asthma

Caramori

Groneberg

Ito

et al. 2008

Journal of Occupational Medicine and Toxicology

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Asthma represents a profound worldwide public health problem. The most effective anti-asthmatic drugs currently available include inhaled β2-agonists and glucocorticoids and control asthma in about 90-95% of patients. The current asthma therapies are not cures and symptoms return soon after treatment is stopped even after long term therapy. Although glucocorticoids are highly effective in controlling the inflammatory process in asthma, they appear to have little effect on the lower airway remodelling processes that appear to play a role in the pathophysiology of asthma at currently prescribed doses. The development of novel drugs may allow resolution of these changes. In addition, severe glucocorticoid-dependent and resistant asthma presents a great clinical burden and reducing the side-effects of glucocorticoids using novel steroid-sparing agents is needed. Furthermore, the mechanisms involved in the persistence of inflammation are poorly understood and the reasons why some patients have severe life threatening asthma and others have very mild disease are still unknown. Drug development for asthma has been directed at improving currently available drugs and findings new compounds that usually target the Th2-driven airway inflammatory response. Considering the apparently central role of T lymphocytes in the pathogenesis of asthma, drugs targeting disease-inducing Th2 cells are promising therapeutic strategies. However, although animal models of asthma suggest that this is feasible, the translation of these types of studies for the treatment of human asthma remains poor due to the limitations of the models currently used. The myriad of new compounds that are in development directed to modulate Th2 cells recruitment and/or activation will clarify in the near future the relative importance of these cells and their mediators in the complex interactions with the other pro-inflammatory/anti-inflammatory cells and mediators responsible of the different asthmatic phenotypes. Some of these new Th2-oriented strategies may in the future not only control symptoms and modify the natural course of asthma, but also potentially prevent or cure the disease.

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“…Several different hookworms may cause CLM, with species varying by geography. In the Northern and Southeastern U.S., the most common organisms are Necator americanus and Ancylostoma braziliense, respectively [4,5]. Dog and cat feces are sources of hookworm eggs, which spread by direct contact with host skin.…”

Section: Case Discussionmentioning

confidence: 99%

Cutaneous larva migrans in the northeastern US

Johanis,

Cheema,

Young

et al. 2023

DOJ

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Necatoriasis: treatment and developmental therapeutics

Cited by 15 publications

References 99 publications

First report of the molecular detection of Ancylostoma caninum in Lahore, Pakistan: the threat from pets

First report of the molecular detection of Ancylostoma caninum in Lahore, Pakistan: the threat from pets

New drugs targeting Th2 lymphocytes in asthma

Cutaneous larva migrans in the northeastern US

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