Differential Effects of Sepsis and Chronic Inflammation on Diaphragm Muscle Fiber Type, Thyroid Hormone Metabolism, and Mitochondrial Function

Bloise, Flávia Fonseca; Spek, Anne H van der; Surovtseva, Olga V.; Ortiga-Carvalho, Tânia M.; Fliers, Eric; Boelen, Anita

doi:10.1089/thy.2015.0536

Cited by 20 publications

(27 citation statements)

References 27 publications

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“…Nevertheless, septic patients had decreased SM DIO2 expression, whereas muscle DIO3 expression increased (Rodriguez-Perez et al 2008). In this sense, murine severe Streptococcus pneumoniae infection decreased limb muscle and diaphragm Dio2 expression, whereas Dio3 remained unchanged in limb muscle, but increased in the diaphragm (Kwakkel et al 2009, Bloise et al 2016. Furthermore, acute inflammation induces an increase in Dio2 and a decrease in Dio3 expression in hind limb (Kwakkel et al 2009, Boelen et al 2017.…”

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

“…Meanwhile, chronic aseptic inflammation induces the expression of D2 and D3 in limb muscle (Kwakkel et al 2009), probably leading to an increase in intracellular T 2 . However, Dio3 expression decreased and Dio2 expression did not significantly change in the diaphragm of mice under chronic aseptic inflammation (Bloise et al 2016). Conversely, intramuscular T 4 and T 3 decrease in different NTIS models, lipopolysaccharide (LPS) induction of acute inflammation, chronic aseptic inflammation and bacterial sepsis (Boelen et al 2017).…”

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

“…Acute and critical illnesses also induce changes in TH metabolism, including alterations in SM responsiveness to TH (Fliers et al 2014). Deiodinase, THR and TH transporter expression are modulated in SM during acute, chronic and systemic inflammation (Boelen et al 2011, Bloise et al 2016, Van den Berghe 2016. These changes affect TH responsiveness and can lead to altered muscle function.…”

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

“…Sepsis and chronic inflammation mouse models decrease hind limb muscle Thra expression, whereas Thra is increased in the diaphragm during chronic inflammation (Kwakkel et al 2009, Bloise et al 2016, Boelen et al 2017. During acute inflammation, the decrease in muscle expression of Dio3 is dependent on Thra; however, Dio2 upregulation is not impacted by Thra in mouse limb muscle (Kwakkel et al 2009).…”

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

“…Because the low free T 4 levels are associated with the severity of the disease (Van den Berghe 2016), these data suggest that the sickest patients would have an increase in MCT8 expression in muscle cells. Meanwhile, murine diaphragm Slci6a2 expression decreases during sepsis; however, chronic inflammation did not change its expression (Bloise et al 2016). In addition, hind limb Slci6a2 expression did not change during acute or chronic inflammation, although it decreased during bacterial sepsis (Boelen et al 2017).…”

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

See 4 more Smart Citations

Role of thyroid hormone in skeletal muscle physiology

Bloise

Cordeiro

Ortiga-Carvalho

2018

Journal of Endocrinology

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136

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Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic metabolism are influenced by TH. These effects depend on the presence of the TH transporters MCT8 and MCT10 in the plasma membrane, the expression of TH receptors (THRA or THRB) and hormone availability, which is determined either by the activation of thyroxine (T 4 ) into triiodothyronine (T 3 ) by type 2 iodothyronine deiodinases (D2) or by the inactivation of T 4 into reverse T 3 by deiodinases type 3 (D3). SM relaxation and contraction rates depend on T 3 regulation of myosin expression and energy supplied by substrate oxidation in the mitochondria. The balance between D2 and D3 expression determines TH intracellular levels and thus influences the proliferation and differentiation of satellite cells, indicating an important role of TH in muscle repair and myogenesis. During critical illness, changes in TH levels and in THR and deiodinase expression negatively affect SM function and repair. This review will discuss the influence of TH action on SM contraction, bioenergetics metabolism, myogenesis and repair in health and illness conditions.

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Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

Section: Influence Of Illness On Skeletal Muscle Thyroid Hormone Signmentioning

confidence: 99%

See 3 more Smart Citations

Role of thyroid hormone in skeletal muscle physiology

Bloise

Cordeiro

Ortiga-Carvalho

2018

Journal of Endocrinology

Self Cite

136

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An update on non-thyroidal illness syndrome

Fliers

Boelen

2020

J Endocrinol Invest

100

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The non-thyroidal illness syndrome (NTIS) was first reported in the 1970s as a remarkable ensemble of changes in serum TH (TH) concentrations occurring in probably any severe illness. Ever since, NTIS has remained an intriguing phenomenon not only because of the robustness of the decrease in serum triiodothyronine (T3), but also by its clear correlation with morbidity and mortality. In recent years, it has become clear that (parenteral) feeding in patients with critical illness should be taken into account as a major determinant not only of NTIS but also of clinical outcome. Moreover, both experimental animal and clinical studies have shown that tissue TH concentrations during NTIS do not necessarily reflect serum low TH concentrations and may decrease, remain unaltered, or even increase according to the organ and type of illness studied. These differential changes now have a solid basis in molecular studies on organ-specific TH transporters, receptors and deiodinases. Finally, the role of inflammatory pathways in these non-systemic changes has begun to be clarified. A fascinating role for TH metabolism in innate immune cells, including neutrophils and monocytes/macrophages, was reported in recent years, but there is no evidence at this early stage that this may be a determinant of susceptibility to infections. Although endocrinologists have been tempted to correct NTIS by TH supplementation, there is at present insufficient evidence that this is beneficial. Thus, there is a clear need for adequately powered randomized clinical trials (RCT) with clinically relevant endpoints to fill this knowledge gap.

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Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors

Lang

Wang

et al. 2018

Food and Chemical Toxicology

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Differential Effects of Sepsis and Chronic Inflammation on Diaphragm Muscle Fiber Type, Thyroid Hormone Metabolism, and Mitochondrial Function

Cited by 20 publications

References 27 publications

Role of thyroid hormone in skeletal muscle physiology

Role of thyroid hormone in skeletal muscle physiology

An update on non-thyroidal illness syndrome

Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors

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