Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors

Li, Fang; Lang, Fangfang; Wang, Yidan; Zhai, Chengkai; Zhang, Chuanbei; Zhang, Liping; Hao, Enkui

doi:10.1016/j.fct.2018.05.053

Cited by 22 publications

(14 citation statements)

References 39 publications

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“…C3G is formed by combining cyanidin with aglycon and glycoside, so we speculate that PSPA rich in cyanidin can also improve cardiotoxicity. In addition, previous studies have shown that cyanidin can also regulate endotoxin‐induced cardiotoxicity through mitochondria or other factors, thus achieving the amelioration of cardiotoxicity (Li, Lang, et al, 2018). Therefore, we speculate that PSPA has the same effect on DOX‐induced cardiotoxicity.…”

Section: Resultsmentioning

confidence: 99%

Anthocyanins from purple sweet potato alleviate doxorubicin‐induced cardiotoxicity in vitro and in vivo

et al. 2021

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In this study, anthocyanins were extracted and purified from purple sweet potato anthocyanins (PSPA) and the alleviative effect of PSPA on doxorubicin (DOX)‐induced cardiotoxicity was investigated. High Performance Liquid Chromatography‐Mass Spectrometry (HPLC‐MS) results showed that 10 kinds of substances were identified in PSPA and the PSPA was mainly composed of cyanidin (62.9%) and peonidin (21.46%). In in vitro experiments, PSPA reduced the excessive release of inflammatory factors (NO and TNF‐α) induced by DOX and decreased the secretion of trimethylamine oxide (TMAO), lactic dehydrogenase (LDH), and creatine kinase (CK) caused by myocardial injury. In in vivo experiments, PSPA inhibited the release of NO and MDA levels in heart tissue. Meanwhile, mice treated with PSPA decreased the levels of LDH, CK, TNF‐α, and TMAO in serum and heart tissue when compared with the DOX group. In addition, the histopathological results of the heart tissue also showed a protective effect of PSPA on the pathological changes in heart. These results provide a reference for the application of PSPA as a functional food to intervene in DOX‐induced cardiotoxicity. Practical applications The effects of anthocyanins from purple sweet potato anthocyanins (PSPA) on doxorubicin (DOX)‐induced cardiotoxicity were investigated in vitro and in vivo. The results indicated that PSPA could significantly ameliorate DOX‐induced heart failure. The obtained results could provide the potential application of PSPA as an alternative therapy for cardiotoxicity caused by DOX in the functional food industry.

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Section: Resultsmentioning

confidence: 99%

Anthocyanins from purple sweet potato alleviate doxorubicin‐induced cardiotoxicity in vitro and in vivo

et al. 2021

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“…TNF-α is a community of cytotoxic pro-inflammatory cytokines, believed to play a vital role in liver damage initiation [84] . Increased circulating TNF-α activates cell surface TNF-α receptors, resulting in activation of the stress-related protein kinases JNK and IKKβ, leading to increased development of additional inflammatory cytokines such as IL6.…”

Section: Discussionmentioning

confidence: 99%

The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

Hassan¹,

Hammam

Awadallah³

et al. 2020

Preprint

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ObjectiveAcute liver failure (ALF) is a clinical condition with an unclear history of pathophysiology, making it a challenging task for scientists to reverse the disease in its initial phase and to help the liver re-function as usual: this study was proposed to estimate the hepatoprotective effects of Punicagranatum peel and Pistaciaatlantica leaves as a multi-rich antioxidants ingredients either in their normal and/or in their nano forms against thioacetamide induced acute liver failure in a rodent model.MethodSixty male Wistar rats were divided into six equal groups, the first group employed as a control; the second group was given a dose of thioacetamide (TAA)-350 mg/bwip., from the third to the sixth group received TAA □ 2ml of 100gm of aqueous extracts of PunicagranatumL and Pistaciaatlantica either in their normal and/or Nano forms consecutively along 2 weeks.Resultsrecorded significant elevation in liver enzymes, lipid profiles, LPO and NO with marked significant decrease in GSH and SOD accompanied by elevation in inflammatory cytokine (IL6,TNF-α and AFP) in addition to a noticeable increase in HSP70 level & degradation in DNA respectively in TAA challenged group. However significant and subsequent amelioration of most of the impaired markers has been observed with ipnano treatment of both extracts.ConclusionThe current results highlighted the high performance of both plant nano extracts and their hepatoprotective impact and their possible therapeutic role in the amelioration of TAA induced acute liver failure in experimental animals.

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“…Icariin also preserved Ca 2+ homeostasis and mitochondrial membrane potential stability [130]. Moreover, cyanidin, an anthocyanin pigment, improved mitochondrial function in mice with lipopolysaccharide-induced myocardial injury by reducing oxidative damage through the associated factor Opa1 and the antioxidant gene thioredoxin-1 (Trx1) [131]. Tilianin, a natural flavonoid glycoside, is known for its cardioprotective effect against myocardial ischemia/reperfusion injury (MIRI).…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention

Koklesová

Líšková

Samec

et al. 2021

IJMS

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Multi-factorial mitochondrial damage exhibits a “vicious circle” that leads to a progression of mitochondrial dysfunction and multi-organ adverse effects. Mitochondrial impairments (mitochondriopathies) are associated with severe pathologies including but not restricted to cancers, cardiovascular diseases, and neurodegeneration. However, the type and level of cascading pathologies are highly individual. Consequently, patient stratification, risk assessment, and mitigating measures are instrumental for cost-effective individualized protection. Therefore, the paradigm shift from reactive to predictive, preventive, and personalized medicine (3PM) is unavoidable in advanced healthcare. Flavonoids demonstrate evident antioxidant and scavenging activity are of great therapeutic utility against mitochondrial damage and cascading pathologies. In the context of 3PM, this review focuses on preclinical and clinical research data evaluating the efficacy of flavonoids as a potent protector against mitochondriopathies and associated pathologies.

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Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors

Cited by 22 publications

References 39 publications

Anthocyanins from purple sweet potato alleviate doxorubicin‐induced cardiotoxicity in vitro and in vivo

Anthocyanins from purple sweet potato alleviate doxorubicin‐induced cardiotoxicity in vitro and in vivo

The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention

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