Differential effects of multiple and single irradiations upon the primate equilibrium function

Non-Human Primate Model for Performance Effects of Ethanol

“…Among the environmental hazards that have been studied are ionizing (2,34,49) and nonionizing (41) radiation, chemical warfare agents (4,5,7,8), and chemical warfare defense pretreatments and/or therapies (6,15,30,33,48). The work reported here is part of an effort to increase the accuracy of extrapolations of performance effects from animal models to human conditions.…”

“…The PEP task is a non-human primate model that the Air Force has used for more than 20 years to measure the effects of hazardous environments on performance. Among the environmental hazards that have been studied are ionizing (2,34,49) and nonionizing (41) radiation, chemical warfare agents (4,5,7,8), and chemical warfare defense pretreatments and/or therapies (6,15,30,33,48).…”

Protracted low-dose ionizing radiation effects upon primate performance

“…Control of the PEP requires continuous attention and corrective action via a relatively sophisticated motor response. The PEP has proved valuable in past research designed to investigate pulsed radiation effects (2,3,4). Thus, its selection for this experiment was based on proven usability as well as task similarity to aircraft manual flight controls.…”

“…The experimentalist maintains an advantage, however, of being able to design experiments which correlate very closely to the operational situation. Using interspecies modeling techniques, these experimental data can be used to estimate radiation impact upon aircrew performance, Past experimental research has largely been devoted to high-dose, pulsed radiation (neutron and gamma) exposures which generally resulted in relatively drastic changes in performance (2,3,4). Basic laboratory simulations of operational parameters led to reasonable estimates of crew vulnerability given such high-dose environments.…”