Differential Effects of Long-Term Cardioselective and Nonselective Beta-Receptor Blockade on Plasma Catecholamines During and After Physical Exercise in Hypertensive Patients

Franz, I.-W.; Lohmann, Friedrich; Koch, G.

doi:10.1097/00005344-198001000-00005

Cited by 36 publications

(11 citation statements)

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“…Standardized ergometer exercise tests are particularly appropriate in assessing adrenosympathetic activity. While emotional stress may result in significant deviation from basal catecholamine levels [6,30], sympathetic ac tivity in terms of plasma catecholamines dur ing standardized exercise is highly reproduc ible [15][16][17], In this study, exercise blood pressures were obtained by auscultation. Several stud ies indicate that there is no significant differ ence between the systolic blood pressure val ues obtained by the traditional noninvasive cuff techniques and the values during intra arterial monitoring [7,41,50].…”

Section: Discussionmentioning

confidence: 99%

Ergometry in the Assessment of Arterial Hypertension

Franz¹

1985

Cardiology

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The blood pressure behavior during and after ergometric exercise was investigated in 552 males in order to clarify if this standardized procedure is suitable for differentiating between normotensive subjects and hypertensive patients. Patients suffering from mild hypertension showed significantly (p < 0.001) higher blood pressures (213 ± 22/116 ± 11 mm Hg) at 100 W and after loading than age-matched normotensives (188 ± 14/92 ± 9 mm Hg) but significantly (p < 0.001) lower values than hypertensives with stable hypertension (225 ± 22/126 ± 11 mm Hg). Moreover, the systolic pressure response to ergometric work was significantly (p < 0.05 – p < 0.01) influenced by age. Using the normal upper limits for blood pressure during and after ergometry the ergometric procedure revealed that 50% of the patients with borderline hypertension at rest could be classified as hypertensives. Their blood pressure response at 100 W (216 ± 21/113 ± 8 mm Hg) did not significantly differ from the patients with mild hypertension. In contrast, in the 50% who reacted negatively to ergometric testing, the systolic blood pressure response at 100 W (204 ± 18 mm Hg) was significantly (p < 0.01) lower than that of those who demonstrated a positive reaction, revealing exactly the same diastolic blood pressure value of 92 mm Hg as the normotensives. The present study strongly suggests that the assessment of blood pressure during ergometric testing is quite useful in distinguishing between normotensive and hypertensive patients and in making estimates of blood pressure response to daily stress more accurate.

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Section: Discussionmentioning

confidence: 99%

Ergometry in the Assessment of Arterial Hypertension

Franz¹

1985

Cardiology

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“…Recently it has become evident that quite a few pharmacological agents that interfere with hemodynamic regulation, such as a-and 0-receptor blockers (11), vasodilators and other antihyperterisives, and calcium antagonists (12) also affect and modulate levels of circulating epinephrine and/or norepinephrine during both rest and exercise. While in most cases either the exact mechanism by which these changes occur, or their physiological significance is not precisely known, it is probable that they have important clinical and therapeutical implications (11).…”

Section: Exercise Adrenergic Activity In Adults and Boysmentioning

confidence: 99%

“…While in most cases either the exact mechanism by which these changes occur, or their physiological significance is not precisely known, it is probable that they have important clinical and therapeutical implications (11). In the few instances where plasma dopamine was also determined it was not found to be significantly changed after acute or short-term treatment with agents such as /3-receptors (11), -0-receptor blockers (13), and calcium antagonists (12).…”

Section: Exercise Adrenergic Activity In Adults and Boysmentioning

confidence: 99%

Radioenzymatic Determination of Epinephrine, Norepinephrine and Dopamine in 0.1 ml Plasma Samples. Plasma Catecholamine Response to Submaximal and Near Maximal Exercise

Koch¹,

Johansson²,

Arvidsson³

1980

CCLM

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Summary: A sensitive enzymatic isotope derivative method for simultaneous determination of epinephrine, norepinephrine, and dopamine in 0.1 ml plasma samples is described. The assay consists basically of 1. conversion of epinephrine, norepinephrine, and dopamine into their respective methyl-derivates in the presence of catechol-O-methyltransferase and S-adenosylmethionine-[ The effect of standing upright and of submaximal and near-maximal steady state exercise on plasma epinephrine, norepinephrine, dopamine and plasma renin was studied in 16 young adults aged 22 to 34 years and 9 physically well trained boys 16-17 years old. Standing upright for 2 min did not result in significant changes in either epinephrine, norepinephrine, dopamine or plasma renin activity compared with supine (basal) values. During exercise, epinephrine, norepinephrine, dopamine and plasma renin activity increased exponentially with the work load, peak values being attained at the highest load or immediately after cessation of exercise. The respective maximal values for plasma renin activity and epinephrine and norepinephrine levels were approximately 3,6 and 10 fold higher than basal values in the adults, and rose as high as 4,10 and 20 fold in the boys. Peak dopamine values were only 2-3 times higher than the basal values in both adults and boys. It is concluded that the method described provides a suitable tool for a quantitative assessment of adreno-sympathetic tone during physiological and pathophysiological conditions.

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“…Durch diese Ergebnisse werden unsere frfiheren vergleichenden Untersuchungen zwischen dem fl~-selektiven Rezeptorenblocker Metoprotol und Pindolol bezfiglich des Plasmaglukose-und Adrenalin.Spiegels bestfitigt [12,13,15]. Auch besteht eine gute Ubereinstimmung mit den von Galbo et al 1976 durchgeffihrten Akutversuchen nach intraven6ser Applikation des gemischten fi~-fi2-Rezeptorenblockers Propranolol.…”

Section: Blutzuckerunclassified

Unterschiedlicher Einflu� einer chronischen, �berwiegend ?1-selektiven und ?1??2-Rezeptorenblockade auf den Kohlenhydratstoffwechsel

1980

Klin Wochenschr

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1. The effects of long-term betal-selective (500 mg acebutolol) and nonselective (15 mg pindoloi) beta-receptor blockade on blood pressure, carbohydrate metabolism and plasma insulin and ACTH levels were studied at rest and during a short-telan (6 min, 100 W), long-term (30 min under steady state conditions with a heart rate of 130 min-1) and maximal ergometric work and 5 min after exercise in 11 moderately hypertensive men (mean 37 years) using a single-blind, crossover design.2. The ant±hypertensive effects of acebutolol and pindolol were virtually identical (p < 0.01) both at rest and in association with exercise. During exercise heart rates were similarly reduced by both drugs.3. However, there was a marked and significant drop in the blood glucose levels in the 30th min of ergometric work on .pindolol (P) as compared with acebutolol (A; p< 0.01) and with the Control group (C; p<0.001) (C69.1±8.9; A65.3+8.3; P54.5+ 8.7 mg/dl). The same phenomenon was observed during maximal work (C70.4-+10.7; A67.6-+8.7; P 54.1 ± 12 mg/dl). 4. Plasma insulin levels decreased significantly (p < 0.05) during exercise and were not significantly affected either by acebutolol or by pindolol.5. In the pretreatment examination there was a significant (p<0.05) increase of the plasma ACTH level in the 30th min of ergometric work. This concentration was not significantly affected by acebutolol but was increased by pindolol (p < 0.05) (C 60-+ 43.8 ; A 64 + 42.7 ; P 117.3 ± 108.8 pg/ml). * Mit Unterstfitzung des Bundesinstituts ffir SportwissenschaftSonderdruckanfragen an : Ass. Prof. Dr. med. I.-W. Franz (Adresse s. nach Literatur)

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Differential Effects of Long-Term Cardioselective and Nonselective Beta-Receptor Blockade on Plasma Catecholamines During and After Physical Exercise in Hypertensive Patients

Cited by 36 publications

References 0 publications

Ergometry in the Assessment of Arterial Hypertension

Ergometry in the Assessment of Arterial Hypertension

Radioenzymatic Determination of Epinephrine, Norepinephrine and Dopamine in 0.1 ml Plasma Samples. Plasma Catecholamine Response to Submaximal and Near Maximal Exercise

Unterschiedlicher Einflu� einer chronischen, �berwiegend ?1-selektiven und ?1??2-Rezeptorenblockade auf den Kohlenhydratstoffwechsel

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