Unterschiedlicher Einflu� einer chronischen, �berwiegend ?1-selektiven und ?1??2-Rezeptorenblockade auf den Kohlenhydratstoffwechsel

Abstract

1. The effects of long-term betal-selective (500 mg acebutolol) and nonselective (15 mg pindoloi) beta-receptor blockade on blood pressure, carbohydrate metabolism and plasma insulin and ACTH levels were studied at rest and during a short-telan (6 min, 100 W), long-term (30 min under steady state conditions with a heart rate of 130 min-1) and maximal ergometric work and 5 min after exercise in 11 moderately hypertensive men (mean 37 years) using a single-blind, crossover design.2. The ant±hypertensive effects of acebutolol and pindolol were virtually identical (p < 0.01) both at rest and in association with exercise. During exercise heart rates were similarly reduced by both drugs.3. However, there was a marked and significant drop in the blood glucose levels in the 30th min of ergometric work on .pindolol (P) as compared with acebutolol (A; p< 0.01) and with the Control group (C; p<0.001) (C69.1±8.9; A65.3+8.3; P54.5+ 8.7 mg/dl). The same phenomenon was observed during maximal work (C70.4-+10.7; A67.6-+8.7; P 54.1 ± 12 mg/dl). 4. Plasma insulin levels decreased significantly (p < 0.05) during exercise and were not significantly affected either by acebutolol or by pindolol.5. In the pretreatment examination there was a significant (p<0.05) increase of the plasma ACTH level in the 30th min of ergometric work. This concentration was not significantly affected by acebutolol but was increased by pindolol (p < 0.05) (C 60-+ 43.8 ; A 64 + 42.7 ; P 117.3 ± 108.8 pg/ml). * Mit Unterstfitzung des Bundesinstituts ffir SportwissenschaftSonderdruckanfragen an : Ass. Prof. Dr. med. I.-W. Franz (Adresse s. nach Literatur)