Differential effects of estrogen and testosterone on auditory sensory gating in rats

Thwaites, Shane J.; Buuse, Maarten van den; Gogos, Andrea

doi:10.1007/s00213-013-3231-5

Cited by 12 publications

(4 citation statements)

References 53 publications

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“…The present data confirm previous findings where treatment with 17β-oestradiol prevented dopamine-mediated deficits in PPI , as well as dopamine-mediated disruptions of other paradigms, including N1 sensory gating (Thwaites et al, 2014) and latent inhibition (Arad and Weiner, 2010). We have suggested that oestradiol can exert this effect by down-regulating dopamine D 2 receptors in the nucleus accumbens, however changes in the density of the dopamine transporter may also play a role .…”

Section: Discussionsupporting

confidence: 92%

Comparing the effects of 17β-oestradiol and the selective oestrogen receptor modulators, raloxifene and tamoxifen, on prepulse inhibition in female rats

Gogos

Buuse

2015

Schizophrenia Research

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Section: Discussionsupporting

confidence: 92%

Comparing the effects of 17β-oestradiol and the selective oestrogen receptor modulators, raloxifene and tamoxifen, on prepulse inhibition in female rats

Gogos

Buuse

2015

Schizophrenia Research

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“…This is important because various environmental conditions, such as housing, are known to affect behaviour . Thus, in the present study, we used our established chronic 17β‐oestradiol treatment model in rats and measured three widely used, validated behaviours relevant to depression: SPT, FST and NORT. We also measured activity in the open field test and the novelty suppressed feeding test aiming to evaluate whether locomotion, anxiety and motivation are implicated in the effects of chronic 17β‐oestradiol treatment on depressive‐like behaviour.…”

Section: Introductionmentioning

confidence: 99%

Differential effects of chronic 17β‐oestradiol treatment on rat behaviours relevant to depression

Gogos

McCarthy

Walker

et al. 2018

J Neuroendocrinology

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| INTRODUC TI ONMajor depressive disorder (MDD) is classified as an affective disorder typified by persistent sadness, a loss of interest in previously enjoyable activities and cognitive deficits including impairments in attention, learning and memory. 1 It is widely accepted that MDD is more prevalent in women than in men. 2,3 Although this difference may be related to psychosocial and cultural factors, it is likely that neurobiological sex differences play an important role. In women, the risk of developing a depressive illness appears to increase during key periods of the reproductive lifecycle when levels of oestrogens and progesterone are changing: during puberty, postnatal period, perimenopause and postpartum. 4,5 Strong links between fluctuations in mood and sex hormones have been reported. 6,7 Additionally, the effects that oestrogens have on cognition, particularly learning and memory, are well-established. 8 Popular theory posits that 17β-oestradiol, the most potent of the endogenous oestrogens, may be neuroprotective, and that the absence of this protection as a result of low oestradiol levels may increase vulnerability to psychiatric disturbance. 7,9 The notion that oestradiol is protective against Sex differences are a prominent feature of the pathophysiology of psychiatric disorders, such as major depressive disorder, which affects women at a higher incidence than men. Research suggests that the most potent endogenous oestrogen, 17βoestradiol, may have therapeutic potential in treating depression. However, preclinical studies have produced mixed results, likely as a result of various methodological factors such as treatment duration. The present study aimed to investigate the effects of ovariectomy and chronic 17β-oestradiol treatment via a s.c. silastic implant on behaviours relevant to depression in adult female Sprague-Dawley rats. Rats were assessed in the forced swim test, saccharin preference test and novel object recognition memory test, as well as for possible confounding behaviours, including locomotion and anxiety (open field test) and motivation and anxiety (novelty suppressed feeding test). Treatment effects were verified using body and uterus weight, as well as serum concentrations of 17β-oestradiol, progesterone and testosterone. Compared to ovariectomised rats, chronic 17β-oestradiol treatment enhanced saccharin preference and novel object recognition performance. There were no group differences in passive or active coping behaviour when assayed using the forced swim test. Taken together, these results support an antidepressant-like action of oestrogens but highlight that the beneficial effects of chronic 17β-oestradiol treatment may be related to specific depression-related symptoms, particularly anhedonia and memory. K E Y W O R D Sfemale rats, forced swim test, locomotor, novel object recognition, novelty suppressed feeding, oestrogen, ovariectomy, sucrose preference

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“…Among the ovarian steroid influences on PPI, estradiol has gained most interest, due to higher PPI in the follicular, relative to the luteal, phase (Kumari, 2011). In addition, estrogen induces a dose-dependent increase in PPI in ovariectomized rats (Charitidi et al, 2012;Van den Buuse and Eikelis, 2001), and prevents 5-HT 1A -, dopamine-, and NMDA receptorinduced disruptions of PPI (Gogos et al, 2010(Gogos et al, , 2012(Gogos et al, , 2006Gogos and Van den Buuse, 2004;Thwaites et al, 2014). While a role for progesterone in PPI has been suggested (Kumari et al, 2010), this effect is presumably not mediated by GABA-active progesterone metabolites (Kask et al, 2009).…”

Section: Lower Ppi In Pregnant Women Compared To Healthy Non-pregnantmentioning

confidence: 99%

Supraphysiological hormonal status, anxiety disorders, and COMT Val/Val genotype are associated with reduced sensorimotor gating in women

Comasco

Hellgren

Olivier

et al. 2015

Psychoneuroendocrinology

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Differential effects of estrogen and testosterone on auditory sensory gating in rats

Abstract: Chronic estrogen replacement in OVX rats protected against sensory gating deficits caused by direct dopamine D1/D2 receptor stimulation. These data could indicate a possible mechanism by which estrogen exerts a protective action in schizophrenia.

Cited by 12 publications

References 53 publications

Comparing the effects of 17β-oestradiol and the selective oestrogen receptor modulators, raloxifene and tamoxifen, on prepulse inhibition in female rats

Comparing the effects of 17β-oestradiol and the selective oestrogen receptor modulators, raloxifene and tamoxifen, on prepulse inhibition in female rats

Differential effects of chronic 17β‐oestradiol treatment on rat behaviours relevant to depression

Supraphysiological hormonal status, anxiety disorders, and COMT Val/Val genotype are associated with reduced sensorimotor gating in women

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