Supraphysiological hormonal status, anxiety disorders, and COMT Val/Val genotype are associated with reduced sensorimotor gating in women

Comasco, Erika; Hellgren, Charlotte; Olivier, Jocelien; Skalkidou, Alkistis

doi:10.1016/j.psyneuen.2015.06.019

Cited by 17 publications

(18 citation statements)

References 54 publications

(62 reference statements)

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“…Kumari et al 2011), with some less common exceptions in human reports, perhaps attributable to the fact that these sex differences are moderated by menstrual phase (Swerdlow et al 1997; Jovanovic et al 2004) and other factors potentially related to reproductive hormones (e.g. Bannbers et al 2010; Kumari et al 2010; Comasco et al 2015, 2016). Male > female PPI was evident in the present sample, and this group difference increased modestly when samples were limited to women of child-bearing years and to non-smokers.…”

Section: Discussionmentioning

confidence: 99%

“…Four previous studies have reported rs4680 Met/Met > Val/Val PPI levels in distinct cohorts, including: 1) male Greek army conscripts (total n=116 across two studies; Roussos et al 2008; Giakoumaki et al 2008), 2) male and female white schizophrenia patients (n = 68; Quednow et al 2010), 3) male white healthy subjects (HS) (n=45; Quednow et al 2010) but not female white HS, and 4) healthy pregnant women (n=154; Comasco et al 2015) but not healthy post-partum women (n=128; Comasco et al 2016). The PPI-moderating effects of rs4680 have been reported using a range of prepulse intensities (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The PPI-moderating effects of rs4680 have been reported using a range of prepulse intensities (e.g. Comasco et al 2015) and intervals (e.g. Roussos et al 2008); cohorts in these studies have generally been young and almost exclusively white, and either of European or Greek origin.…”

Section: Discussionmentioning

confidence: 99%

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Sensorimotor gating in healthy adults tested over a 15 year period

Swerdlow

Bhakta

Rana

et al. 2017

Biological Psychology

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Background Prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, is used to study normal and pathological brain function. From 2001 - 2016, we screened healthy subjects (HS) to establish their suitability for tests of drug effects on PPI. Because of the size and systematic characterization of this sample across variables of relevance to PPI, we now report these screening results. Methods Acoustic startle and PPI were assessed in HS to identify those eligible for studies of drug effects on PPI from 2001-2016, yielding 457 “eligible” subjects. Results Data confirmed the consistency of PPI across this 15-year period, and supported the role of several variables previously reported to moderate either startle or PPI. Conclusions Startle and PPI are robust physiological measures that are predictably moderated by specific physiological variables in healthy adults. As such, these measures serve as robust markers of neurobiological processes in healthy and patient populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sensorimotor gating in healthy adults tested over a 15 year period

Swerdlow

Bhakta

Rana

et al. 2017

Biological Psychology

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“…Both maternal blood samples and amniotic fluid samples were derived from the ‘Biology, Affect, Stress, Imaging, and Cognition in pregnancy and the puerperium’ (BASIC) cohort. The BASIC study investigates biological correlates of mood and anxiety disorders during pregnancy and in the postpartum period ( 28 , 29 , 30 , 31 ). All pregnant women in Uppsala County, Sweden are invited to participate around their routine ultrasound examination in gestational week 17.…”

Section: Methodsmentioning

confidence: 99%

Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain

Kallak¹,

Hellgren²,

Skalkidou³

et al. 2017

European Journal of Endocrinology

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ObjectivePrenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses.MethodsBlood samples from pregnant women (n = 216) obtained in gestational weeks 35–39, and pre-labor amniotic fluid samples from female fetuses (n = 56), taken at planned Caesarean section or in conjunction with amniotomy for induction of labor, were analyzed. Maternal serum testosterone and amniotic fluid testosterone and cortisol were measured by tandem mass spectrometry.ResultsMultiparity (β = −0.28, P < 0.001), self-rated depression (β = 0.26, P < 0.001) and weight gain (β = 0.18, P < 0.05) were independent explanatory factors for the maternal total testosterone levels. Maternal age (β = −0.34, P < 0.001), weight gain (β = 0.19, P < 0.05) and amniotic fluid cortisol levels (β = 0.44, P < 0.001) were independent explanatory factors of amniotic fluid testosterone in female fetuses, explaining 64.3% of the variability in amniotic fluid testosterone.Wider implications of the findingsYoung maternal age and excessive maternal weight gain may increase the prenatal androgen exposure of female fetuses. Further studies are needed to explore this finding.

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“…In this study, the results showed that the pain score in groups AA and GA was significantly higher than that in the GG group, whereas the sedation score in groups AA and GA was lower than that in the GG group. One study has revealed that the activity of COMT is an important regulator of pain sensitivity 21. Another study has also indicated that the Val158Met mutation of the COMT gene can affect the sensitivity of the body to pain by altering the activity of COMT and thus changing the hormone levels and the psychological state 22.…”

Section: Discussionmentioning

confidence: 99%

<p>Association between COMT polymorphism, labor anxiety, and analgesia in pregnant women</p>

Ren

Zhang

Xiao

et al. 2019

JPR

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Background COMT gene polymorphism is associated with mental disorders and sensitivity to pain. In this study, we investigated the association between the COMT gene polymorphism and labor anxiety and analgesia in pregnant women. Subjects and methods A total of 425 pregnant women undergoing labor analgesia were selected from May 2016 to February 2018. The COMT gene polymorphism was detected through the PCR with restriction fragment length polymorphism technique before childbirth. According to a COMT genotype, the enrolled pregnant women were subdivided into the Val/Val (allele GG) group, the Met/Met (allele AA) group, and the Val/Met (allele GA) group. Then, the intervertebral space of all pregnant women was injected with 3 mL of 2% lidocaine +6 mL of 0.08% ropivacaine and 6 µg of fentanyl. Labor analgesia was administered as follows: 80 mg of 0.08% ropivacaine +100 µg of fentanyl + normal saline to 100 mL. The general characteristics of the women were examined and recorded. In addition, the State Anxiety Inventory (SAI), VAS, Ramsay sedation score, and epinephrine and norepinephrine levels were compared and analyzed. Results A total of 391 pregnant women were enrolled in this study; among these pregnant women, there were 180 pregnant women in the GG group, 132 in the GA group, and 99 in the AA group. The minor allele frequency of COMT polymorphism among these pregnant women was 32.8%. Compared with the GG group, the SAI and VAS scores were higher, the Ramsay sedation score was lower, and the epinephrine and norepinephrine levels were higher in AA and GA groups ( P <0.05). Nonetheless, there was no statistically significant difference in the SAI, VAS, Ramsay sedation score, and epinephrine and norepinephrine levels between the groups AA and GA ( P >0.05). Conclusion The COMT gene polymorphism was associated with labor anxiety and analgesia among pregnant women, and the Val158Met mutation in the COMT gene could lead to worse labor anxiety and less-effective labor analgesia in pregnant women.

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Supraphysiological hormonal status, anxiety disorders, and COMT Val/Val genotype are associated with reduced sensorimotor gating in women

Cited by 17 publications

References 54 publications

Sensorimotor gating in healthy adults tested over a 15 year period

Sensorimotor gating in healthy adults tested over a 15 year period

Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain

<p>Association between COMT polymorphism, labor anxiety, and analgesia in pregnant women</p>

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