Differential effects of congenital left and right brain injury on intelligence

Nass, Ruth; Peterson, Hart deCoudres; Koch, Diane

doi:10.1016/0278-2626(89)90035-3

Cited by 57 publications

(26 citation statements)

References 35 publications

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“…Some studies indicate that there is a hierarchy of cognitive development, i.e. right-hemispheric functions develop earlier and their impairment affects proper functioning of the left hemisphere [17, 18]. This concept was supported by a SPECT study of 39 children and young adults (age: 18 days to 19 years) which showed greater cerebral blood flow in the right hemisphere until the third year of life [19].…”

Section: Discussionmentioning

confidence: 57%

Psychiatric Comorbidity in Patients Evaluated for Chronic Epilepsy: A Differential Role of the Right Hemisphere?

et al. 2009

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Introduction: Psychiatric disorders are known to occur frequently in chronic epilepsy. The aim of this study is to investigate the prevalence of psychiatric comorbidity and its relationship to regional cerebral dysfunction in patients admitted to a tertiary epilepsy center for epilepsy surgery. Methods: 217 patients were investigated. A presurgical workup was performed and allowed precise localization of the epileptogenic focus in 156 patients. Sixty-one patients had multifocal or generalized discharges. After 1–3 psychiatric interviews, a psychiatric diagnosis was made (DSM-IV classification). Results: Psychiatric comorbidity was found in 85 patients (39%), more often in those with right or bilateral hemispheric dysfunction (74%, p = 0.04) with no difference between temporal or extratemporal foci location frequency. Additionally, patients with psychiatric disorders were less likely to undergo epilepsy surgery compared to ‘epilepsy-only’ patients (p = 0.003), despite similar good outcome in patients with and without psychiatric comorbidity. Conclusions: Right-sided or bilateral foci seem to represent a risk factor for psychiatric comorbidity in epilepsy, although we did not find any particular association between a psychiatric syndrome and focus localization. Recognition and treatment of psychiatric comorbidity is of major importance since its presence may interfere with patient’s decision making for epilepsy surgery treatment.

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Section: Discussionmentioning

confidence: 57%

Psychiatric Comorbidity in Patients Evaluated for Chronic Epilepsy: A Differential Role of the Right Hemisphere?

et al. 2009

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“…It has often been suggested that the processes of neuronal organization work in a way that tends to spare language at the expense of other cognitive facilities. This observation has been supported by comparisons of verbal and nonverbal intelligence scores in children with focal lesions (Fawer, Diebold, & Calame, 1987;Milner, 1974;Nass, Peterson, & Koch, 1989) and hydrocephalus (Fletcher, Francis, Thompson, Brookshire et al, 1992). The idea is that language is spared because it takes over tissue normally reserved for other cognitive functions.…”

Section: How Does the Brain Organize For Language After Early Lh Injury?mentioning

confidence: 75%

Online Measures of Basic Language Skills in Children with Early Focal Brain Lesions

et al. 2000

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“…The issue of lateralized cognitive deficits after early focal brain lesion has generated a great deal of interest, largely because hemisphere differences are so pronounced after adult brain injury. 32 However, pediatric studies examining lateralized cognitive deficits have yielded highly inconsistent results, 28,[33][34][35] suggesting that the relationship between lesion laterality and outcome is modulated by a variety of other factors including age at injury, lesion severity, and the specific cognitive skill in question. 11,15,20 Because our study was underpowered, it will be necessary to study a larger group of children with right hemisphere neonatal AIS at similar long-term intervals to elucidate the impact of lesion laterality on long-term cognitive outcome.…”

Section: Discussionmentioning

confidence: 99%

Late Emergence of Cognitive Deficits After Unilateral Neonatal Stroke

Westmacott

MacGregor

Askalan

et al. 2009

Stroke

184

146

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Background and Purpose-Neonatal arterial ischemic stroke (AIS) affects a surprisingly large number of children each year, yet little is known about the long-term neuropsychological implications. Methods-Using age-appropriate Wechsler scales of intellectual ability, this longitudinal study examined 26 children with a history of acutely diagnosed unilateral neonatal AIS as preschoolers (3 years 6 months to 5 years 11 months) and again as grade-school students (6 years 1 month to 12 years 5 months), and contrasted performance with the normative sample of the test. Results-As preschoolers, patients' performance did not differ from the normative sample for Full Scale IQ, Verbal IQ, or Performance IQ, and there were no significant differences associated with infarct laterality. As school-age children, performance was significantly lower than the normative sample for Full Scale IQ Working Memory and Processing Speed, but not for Verbal IQ or Performance IQ. Contrasts between Time 1 and Time 2 revealed a significant decline in Full Scale IQ, which reflected emerging deficits in nonverbal reasoning, working memory, and processing speed. Individual subject analyses revealed that 69% of the children showed significant declines in 1 or more IQ index measures. We found no significant differences in cognitive performance associated with lesion laterality, though males performed more poorly than females on several cognitive measures at Time 2. Conclusions-These findings suggest that children with unilateral neonatal stroke, particularly males, are at increased risk for emerging deficits in higher-level cognitive skills during the school years. Continued follow-up of these children is needed, even those with no apparent deficits as toddlers or preschoolers.

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Differential effects of congenital left and right brain injury on intelligence

Cited by 57 publications

References 35 publications

Psychiatric Comorbidity in Patients Evaluated for Chronic Epilepsy: A Differential Role of the Right Hemisphere?

Psychiatric Comorbidity in Patients Evaluated for Chronic Epilepsy: A Differential Role of the Right Hemisphere?

Online Measures of Basic Language Skills in Children with Early Focal Brain Lesions

Late Emergence of Cognitive Deficits After Unilateral Neonatal Stroke

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