Differential effects of chlordiazepoxide and d-amphetamine on responding maintained by a DRL schedule of reinforcement

Sanger, D. J.; Key, Marilyn; Blackman, Derek

doi:10.1007/bf00426110

Cited by 77 publications

(22 citation statements)

References 20 publications

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“…Interestingly, it has been suggested that DA can modulate this internal clock. For instance, systemic administration of methamphetamine or amphetamine in rodents increases internal clock speed, resulting in an overestimation of how much time has passed and thus, faster response times [41–43]. In the current study, intra-NAc amphetamine could have altered the rats’ perception of the delay durations; however, the fact that intra-NAc amphetamine had different effects on choice performance depending on the direction of the delays does not support this interpretation.…”

Section: Discussioncontrasting

confidence: 57%

Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task

Orsini

Mitchell

Heshmati

et al. 2017

Behavioural Brain Research

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Chronic administration of cocaine can cause pronounced and enduring cognitive alterations such as increases in impulsive choice. Chronic cocaine can also result in enhanced dopamine (DA) release in the nucleus accumbens (NAc) in response to reward-related cues. It is possible that this enhanced DA release in the NAc is a mechanism by which cocaine increases impulsive choice. To date, however, the specific role of DA in the NAc in impulsive choice is unclear. To begin to address this, rats received acute microinjections of the indirect DA agonist amphetamine directly into the NAc prior to testing in a delay discounting task in which rats chose between a small, immediate and a large, delayed food reward. When delays to the large reward increased within test sessions, amphetamine increased choice of the large reward. When delays decreased within test sessions, however, amphetamine decreased choice of the large reward. These findings suggest that, rather than specifically mediating impulsive choice, DA neurotransmission in the NAc is necessary for flexible adaptation of choice strategies in the presence of shifting reward contingencies. These results further indicate that enhancements in NAc DA release likely do not account for lasting increases in impulsive choice caused by chronic cocaine.

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Section: Discussioncontrasting

confidence: 57%

Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task

Orsini

Mitchell

Heshmati

et al. 2017

Behavioural Brain Research

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“…This is consistent with previous research suggesting that benzodiazepines can produce rate-dependent effects on certain types of operant behavior. For example, CDP was found to increase overall response rates under differential reinforcement of low rate (DRL) (Sanger et al 1974) and variable-interval (VI) schedules (Sanger and Blackman 1981), but was found to decrease high rates of responding under FR schedules. Interestingly, the specificity of this rate-dependent effect was demonstrated by the fact that CDP did not produce rate-dependent effects under FR schedules that engendered low rates of responding; that is, decreasing the baseline rates of responding by lowering the ratio size did not alter the rate-decreasing effects of CDP.…”

Section: Discussionmentioning

confidence: 96%

Interaction of cocaine with positive GABAA modulators on the repeated acquisition and performance of response sequences in rats

et al. 2005

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“…Electrophysiological and biochemical studies show that SB242,084 increases VTA cell firing, leading to increased DA release within the nucleus accumbens (Di Matteo et al 1999). Since procedures likely to elevate accumbens DA function, such as systemic or intra-accumbens injections of amphetamine, increase premature responding in the 5-CSRTT (Cole and Robbins 1987), and reduce IRT and efficiency in DRL tasks (Sanger et al 1974), the action of SB242,084 to disinhibit responding may result from indirect activation of the mesolimbic dopamine system.…”

Section: Discussionmentioning

confidence: 99%

The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism

et al. 2003

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In the present series of studies, we have investigated the effects of antagonists selective for the 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors on motor and 'impulsive'-type behaviours elicited by the non-competitive N-methyl- d-aspartate (NMDA) antagonist dizocilpine. The selective 5-HT(2A) receptor antagonist M100,907 (0.5 mg/kg) attenuated the hyperlocomotion and stereotypy produced by dizocilpine (0.1-0.3 mg/kg). The selective 5-HT(2B) receptor antagonist SB215,505 (3 mg/kg) and the selective 5-HT(2C) receptor antagonist SB242,084 (0.5 mg/kg) had no effect against either measure, except that SB242,084 produced a small potentiation of the hyperactivity response. Dizocilpine (0.03 mg/kg) increased premature responding in rats performing the 5-choice serial reaction time task (5-CSRTT), and increased response frequency consequently reducing the mean inter-response time (IRT) and efficiency of responding in a DRL24 task. M100,907 (0.5 mg/kg) attenuated each of these effects, as well as the increased premature responding produced by the NMDA NR2B selective antagonist Ro 63-1908 (1 mg/kg) in the 5-CSRTT. In contrast SB242,084 (0.5 mg/kg) did not attenuate the dizocilpine-induced premature responding or increased responding in the DRL24 task. Rather, SB242,084 (0.05-0.5 mg/kg) produced qualitatively similar effects to dizocilpine, increasing premature responding and reducing IRT. The results suggest that 5-HT(2A) receptor antagonists may normalise certain 'impulsive' behaviours produced by NMDA receptor hypofunction. The 5-HT(2C) receptor antagonist SB242,084 failed to exert equivalent effects, rather a trend toward exacerbation of the behavioural changes produced by dizocilpine was apparent.

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Differential effects of chlordiazepoxide and d-amphetamine on responding maintained by a DRL schedule of reinforcement

Cited by 77 publications

References 20 publications

Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task

Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task

Interaction of cocaine with positive GABAA modulators on the repeated acquisition and performance of response sequences in rats

The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism

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