Differential Effects of Acute and Chronic Exercise on Human Neutrophil Functions

Syu, Guan Da; Chen, Hsiun Ing; Jen, Chauying J.

doi:10.1249/mss.0b013e3182408639

Cited by 38 publications

(29 citation statements)

References 23 publications

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“…When compared to sedentary healthy matched controls, physically active individuals aged between 20 and 60 years have increased neutrophil phagocytosis and ROS production [16, 18]. Neutrophil phagocytosis was also improved following 2 months of moderate-intensity exercise training in middle-aged healthy men [28].…”

Section: Discussionmentioning

confidence: 99%

“…Our recent work suggests that neutrophil chemotaxis is better preserved in older adults who performed twice as many steps daily as age-matched controls [15]. Others have shown enhanced neutrophil phagocytosis and improved total numbers in relation to exercise training [16–18]. Exercise training has also been reported to influence monocyte function: CD16 expression and TLR expression were reduced; proinflammatory cytokine production was reduced; expression of the costimulatory molecule CD80 was increased [19–21].…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

Bartlett

Shepherd

Wilson

et al. 2017

Oxidative Medicine and Cellular Longevity

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Neutrophils and monocytes are key components of the innate immune system that undergo age-associated declines in function. This study compared the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on immune function in sedentary adults. Twenty-seven (43 ± 11 years) healthy sedentary adults were randomized into ten weeks of either a HIIT (>90% maximum heart rate) or MICT (70% maximum heart rate) group training program. Aerobic capacity (VO2peak), neutrophil and monocyte bacterial phagocytosis and oxidative burst, cell surface receptor expression, and systemic inflammation were measured before and after the training. Total exercise time commitment was 57% less for HIIT compared to that for MICT while both significantly improved VO2peak similarly. Neutrophil phagocytosis and oxidative burst and monocyte phagocytosis and percentage of monocytes producing an oxidative burst were improved by training similarly in both groups. Expression of monocyte but not neutrophil CD16, TLR2, and TLR4 was reduced by training similarly in both groups. No differences in systemic inflammation were observed for training; however, leptin was reduced in the MICT group only. With similar immune-enhancing effects for HIIT compared to those for MICT at 50% of the time commitment, our results support HIIT as a time efficient exercise option to improve neutrophil and monocyte function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

Bartlett

Shepherd

Wilson

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Whether innate immune function is directly affected by regular exercise has been poorly investigated by others and contrary results have been published. Regular intense exercise leads to a reduced capacity of neutrophils to phagocytose unopsonized latex beads and produce superoxide anions [31], whereas this was not affected [31] or improved [32] by regular moderate exercise. In our phagocytosis assay opsonized live bacteria and whole blood cells in co-culture were used, which allows bacteria-cell and cell-cell interactions that may modulate bacterial defense mechanisms and represents the in vivo situation better.…”

Section: Discussionmentioning

confidence: 96%

Effect of Long-Term Voluntary Exercise Wheel Running on Susceptibility to Bacterial Pulmonary Infections in a Mouse Model

et al. 2013

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Regular moderate exercise has been suggested to exert anti-inflammatory effects and improve immune effector functions, resulting in reduced disease incidence and viral infection susceptibility. Whether regular exercise also affects bacterial infection susceptibility is unknown. The aim of this study was to investigate whether regular voluntary exercise wheel running prior to a pulmonary infection with bacteria (P. aeruginosa) affects lung bacteriology, sickness severity and phagocyte immune function in mice. Balb/c mice were randomly placed in a cage with or without a running wheel. After 28 days, mice were intranasally infected with P. aeruginosa. Our study showed that regular exercise resulted in a higher sickness severity score and bacterial (P. aeruginosa) loads in the lungs. The phagocytic capacity of monocytes and neutrophils from spleen and lungs was not affected. Although regular moderate exercise has many health benefits, healthy mice showed increased bacterial (P. aeruginosa) load and symptoms, after regular voluntary exercise, with perseverance of the phagocytic capacity of monocytes and neutrophils. Whether patients, suffering from bacterial infectious diseases, should be encouraged to engage in exercise and physical activities with caution requires further research.

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“…Exercise has been proposed to be a physiological way to modulate immunity; while acute severe exercise usually impedes immunity, chronic moderate exercise improves it [57,58]. Although the evidence to support these concepts is inconclusive, it supports the idea that exercise-induced immune suppression increases susceptibility to symptoms of infection, particularly around time of competition [59].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Cellular and Metabolic Responses of World-Class Canoeists Training: A Sportomics Approach

et al. 2016

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(1) Background: We have been using the Sportomics approach to evaluate biochemical and hematological changes in response to exercise. The aim of this study was to evaluate the metabolic and hematologic responses of world-class canoeists during a training session; (2) Methods: Blood samples were taken at different points and analyzed for their hematological properties, activities of selected enzymes, hormones, and metabolites; (3) Results: Muscle stress biomarkers were elevated in response to exercise which correlated with modifications in the profile of white blood cells, where a leukocyte rise was observed after the canoe session. These results were accompanied by an increase in other exercise intensity parameters such as lactatemia and ammonemia. Adrenocorticotropic hormone and cortisol increased during the exercise sessions. The acute rise in both erythrocytes and white blood profile were probably due to muscle cell damage, rather than hepatocyte integrity impairment; (4) Conclusion: The cellular and metabolic responses found here, together with effective nutrition support, are crucial to understanding the effects of exercise in order to assist in the creation of new training and recovery planning. Also we show that Sportomics is a primal tool for training management and performance improvement, as well as to the understanding of metabolic response to exercise.

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Differential Effects of Acute and Chronic Exercise on Human Neutrophil Functions

Abstract: ASE and CME differentially affected neutrophil functions, whereas AME was ineffective. Moreover, the fact that CME improves neutrophil functions may partially explain why physically active subjects have a low risk of infection.

Cited by 38 publications

References 23 publications

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

Effect of Long-Term Voluntary Exercise Wheel Running on Susceptibility to Bacterial Pulmonary Infections in a Mouse Model

Investigating the Cellular and Metabolic Responses of World-Class Canoeists Training: A Sportomics Approach

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