Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice

Yuan, Robin K.; Lopez, Matthew R.; Ramos‐Álvarez, Manuel M.; Normandin, M. E. N.; Thomas, Arthur S.; Uygun, David S.; Cerda, Vanessa R.; Grenier, Amandine E.; Wood, Matthew T.; Gagliardi, Celia; Guajardo, Herminio; Muzzio, Isabel A.

doi:10.1016/j.celrep.2021.109234

Cited by 22 publications

(10 citation statements)

References 111 publications

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“…Similar age responses are observed for total sleep deprivation (for 24 h), where young adult rats evidence reduced CA1 spine densities, while spine densities are unchanged in older rats (22 months old) [72]. An age-dependence in response is also observed for short-term sleep loss, where spatial memory consolidation impairments in response to short-term sleep loss in young mice (3 months old), relative to older mice (14 months old) [73] are more pronounced. In adolescent rats, chronic sleep restriction (gentle handling for just 4 h/day for 10 nonconsecutive days) is sufficient to impair hippocampal-dependent memory impairment, although the effect was not compared to adult rats [74].…”

Section: Trends In Neurosciencessupporting

confidence: 60%

Neural consequences of chronic sleep disruption

Zamore

Veasey

2022

Trends in Neurosciences

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Section: Trends In Neurosciencessupporting

confidence: 60%

Neural consequences of chronic sleep disruption

Zamore

Veasey

2022

Trends in Neurosciences

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“…Time spent in all other sleep stages was the same at all sACLS delays. It has been recently reported that spindle count particularly during NREM/ REM sleep transitions which would be scored as PreREM sleep in this study, is a good predictor of behavioral performance in mice during post learning sleep (Yuan et al 2021). Although, we did not specifically count the density of spindle-like activity during this transition period, our results yield consistently, that PreREM sleep duration was longer at Up-state sACLS than at the later stimulation at 300ms delay.…”

Section: Discussionmentioning

confidence: 69%

Single acoustic closed loop stimulation in mice to modulate hippocampo-thalamo-cortical activity and performance

Aksamaz

Moelle

Olubukola

et al. 2022

Preprint

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Neural brain rhythms of sleep reflect neuronal activity underlying sleep-associated memory consolidation. The modulation of brain rhythms, for instance the sleep slow oscillation (SO) is used both to investigate neurophysiological mechanisms as well as to measure the impact on presumed functional correlates. In humans, auditory closed-loop stimulation targeted to the SO Up-state successfully enhanced the slow oscillation rhythm and phase-dependent spindle activity, although effects on memory retention have varied. Here, we aim to disclose relations between stimulation induced hippocampo-thalamo-cortical activity and retention performance on a hippocampus dependent task in mice. Closed-loop acoustic stimuli applied during four SO phases always acutely increased sharp wave ripple (SPWR) activity without disrupting non-rapid eye movement (NREM) sleep. Stimulation achieved an above chance preference index for stimuli delivered across a 3 h retention interval of sleep at the SO Up-state and at the Down-to-Up-state, but not at the Down-state nor late Up-state/Up-to Down-state. Results support the use of closed-loop acoustic stimulation in mice to investigate the inter-regional mechanisms underlying memory consolidation.

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“…However the significance of spindle frequency in rodents remains to be elucidated. A recent study suggested that memory impairment in a hippocampus-dependent object place recognition task in young sleep deprived mice could be associated with an increase in spindle frequency (Yuan et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of hippocampal-thalamocortical temporal coordination during slow-frequency long-duration anterior thalamic spindles

Alizadeh

Azimi

Ghorbani

2021

Preprint

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Temporal nesting of cortical slow oscillations (SO), thalamic spindles and hippocampal ripples indicates the succession of regional neuronal interactions required for memory consolidation. However how the thalamic activity during spindles organizes hippocampal dynamics remains largely undetermined. We analyzed simultaneous recordings of anterodorsal thalamus and CA1 in mice to determine the contribution of thalamic spindles in cross-regional synchronization. Our results indicated that temporal hippocampo-thalamocortical coupling were more enhanced during slower and longer thalamic spindles. Additionally, spindles occurring closer to SO trough were more strongly coupled to ripples. We found that the temporal association between CA1 spiking/ripples and thalamic spindles was stronger following spatial exploration compared to baseline sleep. We further developed a hippocampal-thalamocortical model to explain the mechanism underlying the duration and frequency-dependent coupling of thalamic spindles to hippocampal activity. Our findings shed light on our understanding of the functional role of thalamic activity during spindles on multi-regional information transfer.

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Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice

Cited by 22 publications

References 111 publications

Neural consequences of chronic sleep disruption

Neural consequences of chronic sleep disruption

Single acoustic closed loop stimulation in mice to modulate hippocampo-thalamo-cortical activity and performance

Enhancement of hippocampal-thalamocortical temporal coordination during slow-frequency long-duration anterior thalamic spindles

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