Differential effect of platelet inhibitors in normal and in hypercholesterolaemic subjects.

In the last few years it became obvious that platelets are involved in the development of atherosclerotic diseases. This involvement of platelets has been taken into account in the "response to injury" hypothesis of atherosclerosis. The hypothesis is based on the assumption that atherosclerotic lesions result from endothelial injury, followed by the interaction of vessel wall constituents with lipoproteins, macrophages, and platelets. In the first part of this review, general aspects of platelet activation are summarized and the pathways of platelet aggregation as well as their involvement in blood coagulation are discussed. The second part of this paper describes the influence of cholesterol, lipoproteins, and apolipoproteins upon the activation and metabolic behavior of platelets. Physiological and pathophysiological processes particularly occurring in different types of hyperlipoproteinemias and atherosclerotic disorders are discussed in this context.

show abstract

“…A similar effect was found with other platelet activation inhibitors such as aspirin, indomethacine, and dipyridamol (14).…”

Section: Platelets In Hyperlipoproteinemiasupporting

confidence: 78%

Platelet activation in normo- and hyperlipoproteinemias

et al. 1986

View full text Add to dashboard Cite

show abstract

“…Platelet activation has been shown to be distinctly affected by the plasma lipoprotein environment 18–23 . Incubation with plasma lipoproteins affects in vitro platelet activity 23–26 .…”

Section: Discussionmentioning

confidence: 99%

Plasma Lipoproteins and Platelet Aggregation During Alimentary Lipemia

Winterstein¹,

Brook

Pillar³

et al. 1986

J American Geriatrics Society

View full text Add to dashboard Cite

Ten healthy women in their tenth decade of life were compared with ten healthy women in their fourth decade of life regarding the response of plasma lipoproteins and platelet aggregation to one meal rich in saturated fats. In the elderly group, plasma cholesterol decreased in the postprandial state three hours after the meal in comparison to no significant changes in the younger group. This resulted from reduction in plasma lipoprotein cholesterol levels, except for the high-density lipoprotein (HDL) cholesterol, which was enhanced. A similar pattern was found for plasma lipoprotein levels. The increase in plasma triglyceride concentration in the elderly women was less than in the younger women, as fewer changes in their plasma triglyceride-rich lipoproteins (chylomicrons and very-low-density lipoprotein) were observed. Platelet aggregation in response to collagen was reduced in the elderly women, whereas in the younger group, increased platelet aggregation in the postprandial state was found. Our study thus demonstrates a clear advantage of the elderly women in comparison to the younger ones in reducing atherosclerosis and thrombotic risks. The elderly group responded to the saturated fat-rich meal by minimal plasma triglyceride elevation, an increase in HDL cholesterol concentration, and reduced platelet aggregation.

show abstract