Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice

Lee, Ga Young; Park, Chan Yoon; Sun, Kyeong; Lee, Seung Eun; Pae, Munkyong; Han, Sung Nim

doi:10.1016/j.jnutbio.2018.01.004

Cited by 28 publications

(24 citation statements)

References 45 publications

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“…9,10 Obesity has been associated with chronic, low-grade inflammation and systemic dysregulation of natural killer cell (NK) function. 11,12 Whether obesity is related to poorer tumor immunity is not well established, but some evidence suggests that immune checkpoint blockade therapy in cancer seems to work better in individuals with obesity. 13 One theory is that individuals with obesity may have some defect, such as obesity-induced PD-1 expression and T cell exhaustion and dysfunction, that is corrected with immune checkpoint blockade.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D₃ Supplements on Development of Advanced Cancer

et al. 2020

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IMPORTANCEEpidemiologic and trial data suggest that vitamin D supplementation may reduce metastatic cancer and cancer mortality, reflecting shared biological pathways. OBJECTIVE To follow up on the possible reduction in cancer death in the Vitamin D and Omega-3 Trial (VITAL) with an evaluation of whether vitamin D reduces the incidence of advanced (metastatic or fatal) cancer and an examination possible effect modification by body mass index. DESIGN, SETTING, AND PARTICIPANTS VITAL is a randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial of vitamin D 3 (cholecalciferol, 2000 IU/d) and marine omega-3 fatty acids (1 g/d). This multicenter clinical trial was conducted in the United States; participants included men

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Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D₃ Supplements on Development of Advanced Cancer

et al. 2020

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“…A cohort study of 335 adults (age > 18 years old) with sickle cell anemia, followed at the Chicago Hospital in the United States, found that low vitamin D levels were associated with decreased VDR expression in peripheral blood mononuclear cells 39 . In white adipose tissue of obese rats, VDR gene expression increased after vitamin D supplementation of 50, 1,000, or 10,000 IU/kg for 12 weeks 40 . In 110 patients with oral neoplastic lesions, premalignant lesions, and oral cancer, VDR expression was increased, while insufficient or deficient blood levels of this micronutrient are prevalent in India 41 .…”

Section: Discussionmentioning

confidence: 98%

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

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et al. 2020

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Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRnA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass. our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications. Supplementation with vitamin D (cholecalciferol) has become a widely used practice, since a relationship has been demonstrated of low levels of this nutrient with the increased risk of cardiovascular diseases, the recurrence of diseases, and mortality 1,2,3. However, as there is no consensus on sufficient serum levels of vitamin D, taking into account its non-skeletal functions, it is necessary to assess whether the increase in this nutrient in individuals with 25-hydroxyvitamin D (25 (OH) D) levels above the current cutoff point, generates any health benefits 4. Vitamin D is involved in several non-skeletal functions, such as cell regulation, differentiation, and growth 3 , and adaptive and innate immunity control 5 , as well as being associated with inflammatory markers 6 , since the vitamin D receptor (VDR) is expressed in almost all human cells 7. The activity of this nutrient in the human organism involves its binding with VDR 8 , whose expression is modulated by the blood levels of the 1,25diidroxivitamin D (1,25 (OH) 2D) 9 and genetic variants 10. It is believed that there is a negative correlation between the concentration of 25 (OH) D with the body mass index (BMI) and percentage of fat mass 11. However, few studies have comprehensively evaluated the effect of

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“…Natural killer (NK) cell function depends on adequate vitamin D levels. There are some in vitro studies which have shown that vitamin D suppress NK cell activity and IFN-γ secretion [ 26 , 27 ]. However, little is known about the in vivo effect of vitamin D on NK cell function.…”

Section: Discussionmentioning

confidence: 99%

Significant association between Taq1 gene polymorphism in vitamin D receptor and chronic spontaneous urticaria in the Northeast of Iran

et al. 2021

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Objective Chronic spontaneous urticaria (CSU) is defined as urticaria with an unknown etiology which persists for more than 6 weeks. CSU is an uncomfortable cutaneous condition that occurs due to an immune-mediated inflammatory reaction. Many studies have demonstrated that vitamin D deficiency and single-nucleotide polymorphisms in the vitamin D receptor (VDR) impact the immune response. In the current study, the frequency of the Taq1 polymorphism in the VDR gene were compared between patients with CSU and individuals without CSU. Methods In a case–control study, a group of CSU patients (n = 100) was compared with a group of healthy age- and gender-matched individuals as a control group (n =100) who visited our center between 2015 and 2017. After DNA extraction from EDTA-containing blood, polymerase chain reaction (PCR–RFLP) was used to determine the presence of the Taq1 polymorphism. Serum vitamin D levels were measured using ELISA method (Abcam, Cambridge, USA). Results Genotyping for Taq1 polymorphism showed that TT, Tt and tt genes frequency in the CSU group were 36%, 54%, and 10% respectively. The TT, Tt and tt genotypes had a distribution of 50%, 47% and 3% respectively in the control group. The mean serum vitamin D level in the CSU group was 19.88 ± 8.14 ng/ml, which was not significantly correlated with the Taq1 polymorphism (P = 0.841). There was a significant relationship between Taq1 gene polymorphism (tt genotype) and CSU (P = 0.038). Tt genotype increased the risk of CSU (odds ratio = 1.596), and inheritance of tt genotype increased the risk even further (odds ratio = 4.630). Conclusion The frequency of Taq1 genotype polymorphism in the VDR gene was significantly higher in patients with CSU compared to the control group. The tt genotype polymorphism may be a risk factor for CSU.

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Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice

Cited by 28 publications

References 45 publications

Effect of Vitamin D₃ Supplements on Development of Advanced Cancer

Effect of Vitamin D₃ Supplements on Development of Advanced Cancer

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Significant association between Taq1 gene polymorphism in vitamin D receptor and chronic spontaneous urticaria in the Northeast of Iran

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Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice

Cited by 28 publications

References 45 publications

Effect of Vitamin D3 Supplements on Development of Advanced Cancer

Effect of Vitamin D3 Supplements on Development of Advanced Cancer

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Significant association between Taq1 gene polymorphism in vitamin D receptor and chronic spontaneous urticaria in the Northeast of Iran

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Effect of Vitamin D₃ Supplements on Development of Advanced Cancer

Effect of Vitamin D₃ Supplements on Development of Advanced Cancer