Differential effect of chromium compounds on the immune response of the African mouth breeder Oreochromis mossambicus (Peters)

Ramachandran, A.; Rajasekaran, Priyadharsini; Michael, R. Dinakaran

doi:10.1006/fsim.2000.0281

Cited by 65 publications

(31 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, the present study showed that subcutaneous administration of potassium dichromate in female rats or in males 10 days after exposure in drinking water augmented the number of monocytes and granulocytes. Similar findings have been reported in fish [31] and in mice [21] exposed to Cr (VI) in drinking water, and in rats exposed to an atmosphere containing Cr (VI) [40]. Moreover, chronic exposure to these low clinically relevant concentrations of Cr (VI) induced a potent adaptive response with elevated glutathione-S-transferase expression and increased activities and expression of reactive oxygen scavengers, superoxide dismutases, catalase and glutathione peroxidase, and temporal increases in reduced glutathione levels, glutathione reductase activity, and glutamate cysteine ligase expression [41].…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, our results demonstrated that chromium dichromate in drinking water or administered subcutaneously to male or female rats is susceptible to perturbing the immune response. Indeed, the leucopenia and lymphopenia observed on days 3 and 6 after subcutaneous Cr (VI) administration or on day 20 in drinking water were also observed in mice [21] and in fish [31]. It was reported that Cr (VI) easily enters physiological membranes and is actively transported into cells and remains there for the life of the cell.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Protective effects of selenium against potassium dichromate-induced hematotoxicity in female and male Wistar albino rats

Adjroud

2010

Ann Toxicol Anal

View full text Add to dashboard Cite

-Objective: Potassium dichromate (K 2 Cr 2 O 7 ) is a potent pollutant for human and animal health. The purpose of the current work is to compare the effect of K 2 Cr 2 O 7 using variations in the dose, route of administration and duration of exposure in male and female Wistar albino rats and to research the interaction of chromium and selenium with a special focus on hematopoiesis. Materials and methods: K 2 Cr 2 O 7 was subcutaneously administered alone (10, 50 and 100 mg/kg body weight) or K 2 Cr 2 O 7 (10 mg/kg) in association with selenium (0.3 mg/kg) was administered to female Wistar albino rats. Male rats received in their drinking water K 2 Cr 2 O 7 (30 mg/L/day) alone or in association with Se (0.3 mg/L/day) for 20 consecutive days. The hematological parameters were evaluated on days 3, 6 and 21 after subcutaneous (sc.) treatment in female rats and on days 10 and 20 after oral administration in male rats. Results: K 2 Cr 2 O 7− induced during the first three days a significant (p < 0.05) dose-dependent decrease in the number of erythrocytes, platelets, leucocytes, lymphocytes and the hematocrit levels, and a dose-dependent increase in the number of granulocytes and monocytes. In the drinking water, chromium sc. significantly decreased the number of leucocytes and lymphocytes on day 10 after treatment and elevated the number of granulocytes and monocytes 20 days later. Selenium sc. counterbalanced the hematotoxic effects of chromium in female rats. Conclusion: These results suggest that the selenium has a protective role against the hematotoxicity of subcutaneous chromium in female Wistar rats.Key words: Chromium, rat, selenium, hematotoxicity Résumé -Objectif : Le dichromate de potassium (K 2 Cr 2 O 7 ) est un polluant potentiellement néfaste pour la santé humaine et animale. Cette étude a été entreprise afin de rechercher une éventuelle interaction entre le K 2 Cr 2 O 7 et le sélénium (Se) sur l'hématopoïèse chez les rats albinos Wistar mâles et femelles. Matériel et Méthodes : Le K 2 Cr 2 O 7 est administré seul (10, 50 et 100 mg/kg) par voie sous-cutanée (sc) ou en association (10 mg/kg) avec le sélénium (0,3 mg/kg). Les rats mâles reçoivent dans l'eau de boisson le K 2 Cr 2 O 7 (30 mg/L/jour) seul ou en association avec le sélénium (0,3 mg/L/jour) pendant 20 jours consécutifs. Les variations des paramètres hématologiques sont évaluées au 3 e , 6 e et 21 e jour chez les rattes et au 10 e et 20 e jour chez les mâles. Résultats : Les résultats montrent que le chrome engendre dès le 3 e jour après son administration par voie sc chez la femelle une diminution notable et dose-dépendante (p < 0,05) du nombre d'érythrocytes, du taux d'hématocrite, du nombre de plaquettes sanguines, de leucocytes, de lymphocytes et une augmentation dose-dépendante du nombre de granulocytes et de monocytes. Le chrome administré par voie orale diminue le nombre de leucocytes et de lymphocytes dès le 10 e jour du traitement et augmente celui des monocytes et des granulocytes 20 jours plus tard. La présence du sélénium ...

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Protective effects of selenium against potassium dichromate-induced hematotoxicity in female and male Wistar albino rats

Adjroud

2010

Ann Toxicol Anal

View full text Add to dashboard Cite

show abstract

“…This included production of reactive oxygen reagents and secretion of nitric oxide by granulocytes. Various studies have reported alterations of immune processes in experimental animals upon chromium administration (O'Neill 1981, Glaser et al 1985, Kangarot et al 1999, Arunkumar et al 2000. Chromium affected the distribution of leukocytes (Glaser et al 1985, Arunkumar et al 2000, macrophage functions (Tian & Lawrence 1996), and mitogen-induced proliferation of T-and B-lymphocytes (Snyder & Valle 1991, Wang et al 1996.…”

Section: Discussionmentioning

confidence: 99%

“…In fishes, the exposure of the freshwater catfish Saccobranchus fossilis to subtoxic level of Cr resulted in decreased antibody production, reduced proliferation of splenic lymphocytes, and higher susceptibility to infections with the microorganism Aeromonas hydrophila (Khangarot et al 1999). Exposure of the freshwater cichlid Oreochromis mossambicus to chrome tannery effluents (Sudhan & Michael 1995) or the injection of chromium compounds into the body cavity (Arunkumar et al 2000) resulted in spleen atrophy, decreased leukocyte counts and antibody response upon the injection of bovine serum albumin.…”

Section: Abstract: Heavy Metal · Hexavalent Chromium · Cytotoxity · mentioning

confidence: 99%

Effect of hexavalent carcinogenic chromium on carp Cyprinus carpio immune cells

Steinhagen¹,

Helmus²,

Maurer³

et al. 2004

Dis. Aquat. Org.

View full text Add to dashboard Cite

“…Aeromonas hydrophila is an opportunist pathogen in fish. Motile Aeromonas septicemia (MAS) is a more dramatic bacterial disease affecting various species of fish in both fresh and seawater and cause a serious problem for the fish farming industry in Iran as well as in other countries [2].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Skin Pathological Responses in the Yellowfin Seabream (Acanthopagrus latus) under the Aeromonas hydrophila Exposure

Azadbakht

Shirali

Ronagh

et al. 2018

IJT

View full text Add to dashboard Cite

show abstract

Differential effect of chromium compounds on the immune response of the African mouth breeder Oreochromis mossambicus (Peters)

Cited by 65 publications

References 16 publications

Protective effects of selenium against potassium dichromate-induced hematotoxicity in female and male Wistar albino rats

Protective effects of selenium against potassium dichromate-induced hematotoxicity in female and male Wistar albino rats

Effect of hexavalent carcinogenic chromium on carp Cyprinus carpio immune cells

Assessment of Skin Pathological Responses in the Yellowfin Seabream (Acanthopagrus latus) under the Aeromonas hydrophila Exposure

Contact Info

Product

Resources

About