Differential Distribution of Lipid Microemboli After Cardiac Surgery

Brondén, Björn; Dencker, Magnus; Allers, Mats; Plaza, Ignacio; Jönsson, Henrik

doi:10.1016/j.athoracsur.2005.08.006

Cited by 29 publications

(22 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, fat emboli were found in the kidney in only two of the eight subjects. On the other hand, Brondén et al [26] used tritium-labelled triolein to induce lipid microembolization in pigs. The radioactivity reflected the density of microemboli, and they found higher amounts of radioactive lipid particles in the kidney and spleen than in the lung and brain.…”

Section: Discussionmentioning

confidence: 98%

Clinical and pathological features of fat embolism with acute respiratory distress syndrome

2007

View full text Add to dashboard Cite

FES (fat embolism syndrome) is a clinical problem, and, although ARDS (acute respiratory distress syndrome) has been considered as a serious complication of FES, the pathogenesis of ARDS associated with FES remains unclear. In the present study, we investigated the clinical manifestations, and biochemical and pathophysiological changes, in subjects associated with FES and ARDS, to elucidate the possible mechanisms involved in this disorder. A total of eight patients with FES were studied, and arterial blood pH, PaO(2) (arterial partial pressure of O(2)), PaCO(2) (arterial partial pressure of CO(2)), biochemical and pathophysiological data were obtained. These subjects suffered from crash injuries and developed FES associated with ARDS, and each died within 2 h after admission. In the subjects, chest radiography revealed that the lungs were clear on admission, and pulmonary infiltration was observed within 2 h of admission. Arterial blood pH and PaO(2) declined, whereas PaCO(2) increased. Plasma PLA(2) (phospholipase A(2)), nitrate/nitrite, methylguanidine, TNF-alpha (tumour necrosis factor-alpha), IL-1beta (interleukin-1beta) and IL-10 (interleukin-10) were significantly elevated. Pathological examinations revealed alveolar oedema and haemorrhage with multiple fat droplet depositions and fibrin thrombi. Fat droplets were also found in the arterioles and/or capillaries in the lung, kidney and brain. Immunohistochemical staining identified iNOS (inducible nitric oxide synthase) in alveolar macrophages. In conclusion, our clinical analysis suggests that PLA(2), NO, free radicals and pro-inflammatory cytokines are involved in the pathogenesis of ARDS associated with FES. The major source of NO is the alveolar macrophages.

show abstract

Section: Discussionmentioning

confidence: 98%

Clinical and pathological features of fat embolism with acute respiratory distress syndrome

2007

View full text Add to dashboard Cite

show abstract

“…22 Abundant blood flow and typical sinusoidal capillary bed enhance the process. In experimental studies, 23 spleen and also kidney captured 5-10 times more artificial lipid microemboli than other organs.…”

Section: Discussionmentioning

confidence: 97%

Is splenectomy a dyslipidemic intervention? Experimental response of serum lipids to different diets and operations

Paulo

Morais

et al. 2008

Microsurgery

View full text Add to dashboard Cite

show abstract

“…[31][32][33] Fat embolism to the kidney has rarely been reported. However, Brondén et al, 34 using tritium-labelled triolein in a pig model to induce lipid microembolism and …”

Section: Discussionmentioning

confidence: 99%

Histopathological and biochemical changes following fat embolism with administration of corn oil micelles

Liu

Hsieh

Chen

2008

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

Several experimental models have been used to produce intravascular fat embolism. We have developed a simple technique to induce fat embolism using corn oil emulsified with distilled water to form fatty micelles. Fat embolism was produced by intravenous administration of these fatty micelles in anaesthetised rats, causing alveolar oedema, haemorrhage and increased lung weight.Histopathological examination revealed fatty droplets and fibrin thrombi in the lung, kidney and brain. The arteriolar lumen was filled with fatty deposits. Following fat embolism, hypoxia and hypercapnia occurred. The plasma phospholipase A 2 , nitrate/nitrite, methylguidanidine and proinflammatory cytokines were significantly increased. Mass spectrometry showed that the main ingredient of corn oil was oleic acid.This simple technique may be applied as a new animal model for the investigation of the mechanisms involved in the fat embolism syndrome.

show abstract

Differential Distribution of Lipid Microemboli After Cardiac Surgery

Cited by 29 publications

References 19 publications

Clinical and pathological features of fat embolism with acute respiratory distress syndrome

Clinical and pathological features of fat embolism with acute respiratory distress syndrome

Is splenectomy a dyslipidemic intervention? Experimental response of serum lipids to different diets and operations

Histopathological and biochemical changes following fat embolism with administration of corn oil micelles

Contact Info

Product

Resources

About