Is splenectomy a dyslipidemic intervention? Experimental response of serum lipids to different diets and operations

Paulo, Danilo Nagib Salomão; Paulo, Isabel Cal; Morais, Álvaro A. C.; Kalil, Mitre; Guerra, Alvino Jorge; Colnago, Geraldo Luiz; Faintuch, Joel

doi:10.1002/micr.20568

Cited by 12 publications

(22 citation statements)

References 39 publications

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“…As our model is an undernutrition steatosis model, 12,13 no significant differences were seen between groups in terms of blood lipids. However, according to previous reports using normal and high‐fat diets, splenectomy may worsen blood lipid metabolism 9–11 . This may also have developed due to an exacerbation of fatty liver changes by splenectomy.…”

Section: Discussionmentioning

confidence: 97%

“…In addition, rats fed a normal or high‐fat diet showed decreased HDL‐C and increased TG with splenectomy 10 . In a group of rats fed a normal diet or high‐cholesterol diet with subtotal splenectomy, correction of dyslipidemia was reported 11 . In other words, splenectomy may worsen lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…10 In a group of rats fed a normal diet or high-cholesterol diet with subtotal splenectomy, correction of dyslipidemia was reported. 11 In other words, splenectomy may worsen lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline‐deficient L‐amino acid‐defined diet

Oishi

Terai

Iwamoto

et al. 2011

Hepatology Research

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline‐deficient L‐amino acid‐defined diet

Oishi

Terai

Iwamoto

et al. 2011

Hepatology Research

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“…Reports of the relationship between the spleen and lipid metabolism have emerged: splenectomized rodents showed high cholesterol levels (21), hyperlipidemia (22), and increased intrahepatic fat accumulation (23). Elucidating the kinetics of iron in diabetes and other diseases is expected to lay the foundation for novel irontargeting therapies in the future.…”

Section: Discussionmentioning

confidence: 99%

A Long-Term High-Fat Diet Changes Iron Distribution in the Body, Increasing Iron Accumulation Specifically in the Mouse Spleen

Yamano

Ikeda

Sakama

et al. 2015

J Nutr Sci Vitaminol

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Summary Although iron is an essential trace metal, its presence in excess causes oxidative stress in the human body. Recent studies have indicated that iron storage is a risk factor for type 2 diabetes mellitus. Dietary iron restriction or iron chelation ameliorates symptoms of type 2 diabetes in mouse models. However, whether iron content in the body changes with the development of diabetes is unknown. Here, we investigated the dynamics of iron accumulation and changes in iron absorption-related genes in mice that developed obesity and diabetes by consuming a high-fat diet (HFD-fed mice). HFD-fed mice (18-20 wk) were compared with control mice for hematologic features, serum ferritin levels, and iron contents in the gastrocnemius muscle, heart, epididymal fat, testis, liver, duodenum, and spleen. In addition, the spleen was examined histologically. Iron absorption-related gene expression in the liver and duodenum was also examined. Hemoglobin and serum ferritin levels were increased in HFD-fed mice. The HFD-fed mice showed iron accumulation in the spleen, but not in the heart or liver. Increased percentages of the splenic red pulp and macrophages were observed in HFD-fed mice and iron accumulation in the spleen was found mainly in the splenic red pulp. The HFD-fed mice also showed decreased iron content in the duodenum. The mRNA expression of divalent metal transporter-1 (DMT-1), an iron absorption-related gene, was elevated in the duodenum of HFD-fed mice. These results indicate that iron accumulation (specifi cally accumulation in the spleen) is enhanced by the development of type 2 diabetes induced by HFD. Key Words iron/spleen/diet, high fat/diabetes mellitus, type 2/DMT1 protein (iron transporter)

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“…The authors showed 13 , that rats submitted to splenic surgery and fed with a nutritionally balanced diet kept plasma lipid levels and hyperlipidemia occurred with the use of cholesterol-reducing chow and cholesterol-enriched diet in rats after splenectomy.…”

Section: Introductionmentioning

confidence: 99%

Effect of total splenectomy in the lipid profile in mice

et al. 2015

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PURPOSE:To analyze total splenectomy effect on the lipid profile -total cholesterol, low-density lipoprotein cholesterol (LDL), highdensity lipoprotein cholesterol (HDL), very-low-density lipoprotein cholesterol (VLDL) and triglycerides levels, in Balb/c mice. METHODS:Thirty Balb/c male mice, one (1) month old and average weight 26.2g ± 4.0 were used in the experiment. They were distributed into three groups of 10 animals each: a control group (non-operated), a simulation group (spleen manipulation) and the splenectomy group. The animals were subjected to blood sampling to measure plasma lipid levels, at three different times: before surgery, days 30 and 75 of the experiment. RESULTS:Increased total cholesterol and LDL were observed in the control group from the start to end of the experiment. The simulation group showed increased rates of VLDL and triglycerides at the 30th and 75th days. Splenectomized animals showed no significant change. CONCLUSION:Total splenectomy did not induce increased plasma lipids levels of in Balb/c mice.

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Is splenectomy a dyslipidemic intervention? Experimental response of serum lipids to different diets and operations

Abstract: After splenectomy, hyperlipidemia occurred with both diets. Preservation of the upper pole tended to correct dyslipidemia in modality A and to attenuate it in subgroup B.

Cited by 12 publications

References 39 publications

Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline‐deficient L‐amino acid‐defined diet

Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline‐deficient L‐amino acid‐defined diet

A Long-Term High-Fat Diet Changes Iron Distribution in the Body, Increasing Iron Accumulation Specifically in the Mouse Spleen

Effect of total splenectomy in the lipid profile in mice

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