Differential diagnosis of non-epithelial tumors of the pancreas: malignant non-epithelial pancreatic tumor with focal pigmentation

Bergmann, Frank; Hackert, Thilo; Mechtersheimer, Gunhild; Penzel, Roland; Bläker, Hendrik; Berger, Irina; Espósito, Irene; Büchler, Markus W.; Otto, Herwart F.

doi:10.1007/s00428-003-0940-x

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…On rare occasions, the pancreas gives rise to mesenchymal tumors [5,24]. Due to the clear cell morphology and the strong expression of vimentin, the differential diagnosis of a synovial sarcoma was taken into account.…”

Section: Discussionmentioning

confidence: 99%

Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature

et al. 2007

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Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype. In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity. The tumor was observed in the pancreatic head of a 54-year-old woman. It was found to be a solid infiltrating carcinoma with abundant clear cells. Apart from cytokeratin, the tumor cells expressed vimentin, S100, and MUC-1. DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma. Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas.

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Section: Discussionmentioning

confidence: 99%

Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature

et al. 2007

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“…Furthermore, for the analyses of pancreatic intraepithelial neoplasia lesions, multitissue arrays were designed as described elsewhere (25,26). Sections obtained from both paraffin blocks and multitissue arrays were further processed as previously described (17,27). Briefly, the primary antibody (clone L1-14.10) was used at a concentration of 10 μg/ml and incubated overnight.…”

Section: Methodsmentioning

confidence: 99%

Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma

Bergmann

Wandschneider²,

Sipos³

et al. 2010

Oncol Rep

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The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further elucidating the role of L1CAM in a larger cohort of PDAC specimens including precursor lesions and metastasis. L1CAM expression was determined by immunohistochemistry in tissues of 123 patients including tissues of 110 primary PDACs, 15 lymph node metastases and 14 liver metastases. The immunohistochemical analyses revealed L1CAM expression in 92.7% of primary PDACs, 80% of lymph node metastases and 100% of liver metastases. Furthermore, we have investigated PDAC precursors, pancreatic intraepithelial neoplasia (PanIN) lesions, revealing a significant increase of L1CAM expression with the PanIN grade (6.4 and 6.8% in PanIN 1A and B, 35% in PanIN 2 and 20% in PanIN 3). The elevated expression of L1CAM already found in PanINs points to a role of L1CAM quite early in tumorigenesis of PDAC. Furthermore, its broad expression in primary tumors as well as in metastases of PDAC patients provide a rationale to further explore the value of L1CAM as a therapeutic target in the treatment of this highly malignant tumor.

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“…However, a spectrum of morphologic variants of PanNETs, although very uncommon, has been gradually recognized, and some of these variants have distinct biologic and prognostic significance. [7][8][9][10][11][12][13][14] More importantly, these variants may not retain the classic cytomorphologic features of Pan-NETs. Therefore, these may present as substantial diagnostic challenges, especially in fine-needle aspiration (FNA) specimens, when under recognized.…”

Section: Introductionmentioning

confidence: 99%

Morphologic Variants of Well-Differentiated Pancreatic Neuroendocrine Tumors: Fine-Needle Aspiration Cytomorphology and Diagnostic Pitfalls

Lu¹,

Xu²,

Cai³

2022

J Clin Transl Pathol

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Morphologic variants of well-differentiated pancreatic neuroendocrine tumors (PanNETs) are uncommon. These variants may mimic non-PanNETs, and when under recognized, it would lead to misdiagnosis by fine-needle aspiration (FNA) biopsy. The present report describes the unique cytomorphologic features and diagnostic clues of pigmented, pleomorphic, clear cell/lipid-rich and oncocytic variants of welldifferentiated PanNETs. The differential diagnoses of each morphologic variant are also discussed. Ancillary immunohistochemical studies with appropriate markers are crucial in the diagnostic work-up. Raising the awareness of PanNET morphologic variants is essential for preventing diagnostic pitfalls, and rendering an accurate diagnosis during the FNA diagnostic work-up of pancreatic lesions.

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Differential diagnosis of non-epithelial tumors of the pancreas: malignant non-epithelial pancreatic tumor with focal pigmentation

Cited by 4 publications

References 14 publications

Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature

Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature

Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma

Morphologic Variants of Well-Differentiated Pancreatic Neuroendocrine Tumors: Fine-Needle Aspiration Cytomorphology and Diagnostic Pitfalls

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