Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature

Loos, Martin; Bergmann, Frank; Bauer, Andrea S.; Hoheisel, Jörg D.; Espósito, Irene; Kleeff, Jörg; Schirmacher, Peter; Büchler, Markus W.; Klöppel, Günter; Friess, Helmut

doi:10.1007/s00428-007-0416-5

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…The validity of such an approach has been confirmed by Loos et al [41] who defined a solid type clear cell carcinoma of the pancreas as new tumour entity by applying the methods mentioned above ( fig. 1 ).…”

Section: Examples Of New Tumour Entities Defined By Molecular Analysismentioning

confidence: 54%

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Defining New Pancreatic Tumour Entities by Molecular Analysis

et al. 2009

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Recent advances in molecular biology, biochemistry and genetics have broadened our understanding of tumourigenesis and of the maintenance and spread of pancreatic cancer far beyond traditional microscopic histopathological analysis. While the main focus of pancreatic cancer research has been on pancreatic ductal adenocarcinoma, molecular research has also led to a better understanding of rare tumours of the pancreas, as well as to the definition of previously unknown tumour entities that can only be identified through the application of molecular tools. Furthermore, molecular analysis increasingly reveals the genetic and cell biological heterogeneity of established tumour entities, making subclassification of tumours possible. Genetic and molecular approaches may, therefore, not only lead to a better understanding of the pathogenesis of pancreatic tumours, but also culminate in more precise diagnosis as well as individually tailored treatment strategies for affected patients.

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Section: Examples Of New Tumour Entities Defined By Molecular Analysismentioning

confidence: 54%

“…As all other experiments were compared to this control, only the centre of gravity of all normal tissue samples is shown rather than individual experiments. Reprinted with permission (conferred through the 'Copyright Clearance Center') from Loos et al [41] .…”

Section: Examples Of New Tumour Entities Defined By Molecular Analysismentioning

confidence: 99%

Defining New Pancreatic Tumour Entities by Molecular Analysis

et al. 2009

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“…K-ras analysis showed a point mutation at codon 12 in clear cell carcinoma of pancreas [ 4 , 6 ], while no mutation at codon 12 in either clear cell or duct-like components [ 5 ]. DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma [ 16 ]. Molecularly, it is still unclear whether clear cell carcinoma is a subtype of ductal adenocarcinoma.…”

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Primary Clear Cell Carcinoma of the Pancreas: A Rare Case Report

Kang

2022

Diagnostics

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Most pancreatic carcinoma is ductal adenocarcinoma. Primary pancreatic clear cell carcinomas composed almost entirely of clear tumor cells are very rare. We present a case of a 72-year-old man with a pancreatic mass, which was detected on abdominal computed tomography (CT). He had no symptoms and no abnormal findings on physical examination; however, he had a history of hepatitis B, hepatitis C, and hepatocellular carcinoma. He had received anti-viral treatment and radiofrequency ablation twice until 2 years prior. One year prior, follow-up contrast-enhanced abdominal CT revealed a newly developed pancreatic mass. Laparoscopic radical antegrade modular pancreato-splenectomy was performed. An ill-defined white-to-tan firm solid mass was observed in the pancreas, approximately 4.3 cm in diameter. The tumor cells showed >95% clear cell features, with a large round to oval nuclei and abundant clear cytoplasms, and well-defined cell membranes. Immunohistochemical staining revealed that the tumor cells were positive for cytokeratin 7, cytokeratin 19, HNF-1β, MUC-1, and p53. We excluded the possibility of metastatic clear renal cell carcinoma, neuroendocrine carcinoma, perivascular epithelioid cell tumor, malignant melanoma, and sarcoma because of the negativity for vimentin, chromogranin, synaptophysin, and HMB45. Consequently, he was diagnosed as having primary clear cell carcinoma of the pancreas and was treated with postoperative radiotherapy. Two months later, abdominal CT was suspicious for local recurrence at the resection margin. Additional adjuvant FOLFIRINOX chemotherapy was carried out 12 times. The patient is still alive after his third radiofrequency ablation for the newly-developed hepatic mass. Immunohistochemical staining for MUC-1 and HNF-1β, as well as histologic feature is very helpful for the diagnosis of primary pancreatic clear cell carcinoma with imaging methods for metastasis exclusion.

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Ductal Adenocarcinoma and Variants

Karamitopoulou-Diamantis

2022

Encyclopedia of Pathology

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Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature

Cited by 6 publications

References 34 publications

Defining New Pancreatic Tumour Entities by Molecular Analysis

Defining New Pancreatic Tumour Entities by Molecular Analysis

Primary Clear Cell Carcinoma of the Pancreas: A Rare Case Report

Ductal Adenocarcinoma and Variants

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