Differential diagnosis of multiple system atrophy with predominant parkinsonism and Parkinson's disease using neural networks

Tsuda, Mitsunori; Asano, Shingo; Kato, Yasushi; Murai, Katsumasa; Miyazaki, Masao

doi:10.1016/j.jns.2019.04.014

Cited by 21 publications

(17 citation statements)

References 21 publications

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“…Reduced N-acetyl aspartate/creatine (NAA/Cr) ratios in the SN have been observed in PD vs. controls, which were shown to correlate with disease severity ( 69 , 70 ). Lowered NAA or NAA/Cr values have also been detected in other regions, including the lentiform nucleus (LN) (comprises of putamen and globus pallidus; basic anatomy presented in Figure 2 ), temporoparietal and posterior cingulate cortex, and pre-supplementary motor area vs. controls ( 71 – 74 ). However, the correlation between NAA/Cr ratios in these regions with disease severity or duration is inconsistently reported ( 72 , 73 ).…”

Section: Structural Neuroimaging In Parkinsonian Disordersmentioning

confidence: 91%

“…In MSA-P, VBM studies also show atrophy in the primary motor and supplementary motor cortex indicating sensorimotor cortical degeneration ( 106 , 107 ), as well as in the prefrontal and insular cortices compared to PD ( 106 ). Likewise, VBM analysis in MSA-P vs. PD revealed atrophy in the superior cerebellar peduncle (SCP), MCP, cerebellum, pons, midbrain, and putamen, but not in the globus pallidus ( 71 ). Cerebellar atrophy was evident in both MSA-P and MSA-C subtypes to varying degrees ( 28 , 108 ).…”

Section: Structural Neuroimaging In Parkinsonian Disordersmentioning

confidence: 99%

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Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

2020

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Section: Structural Neuroimaging In Parkinsonian Disordersmentioning

confidence: 91%

Section: Structural Neuroimaging In Parkinsonian Disordersmentioning

confidence: 99%

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

2020

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“…However, it is not widely available and suffers from shortcomings of high cost and radiation hazards [12,13]. Besides structural MRI, functional MRI has additional value for differential diagnosis [14][15][16][17][18]. Among these functional imaging, arterial spin labeling (ASL)-based perfusion-weighted imaging is a novel, non-invasive method that does not require the injection of contrast agent.…”

Section: Introductionmentioning

confidence: 99%

Discriminative pattern of reduced cerebral blood flow in Parkinson’s disease and Parkinsonism-Plus syndrome: an ASL-MRI study

Cheng

Guo

et al. 2020

BMC Med Imaging

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Background: Accurate identification of Parkinson's disease (PD) and Parkinsonism-Plus syndrome (PPS), especially in the early stage of the disease, is very important. The purpose of this study was to investigate the discriminative spatial pattern of cerebral blood flow (CBF) between patients with PD and PPS. Methods: Arterial spin labeling (ASL) perfusion-weighted imaging was performed in 20 patients with PD (mean age 56.35 ± 7.56 years), 16 patients with PPS (mean age 59.62 ± 6.89 years), and 17 healthy controls (HCs, mean age 54.17 ± 6.58 years). Voxel-wise comparison of the CBF was performed among PD, PPS, and HC groups. The receiver operating characteristic (ROC) curve was used to evaluate the performance of CBF in discriminating between PD and PPS. The relationship between CBF and non-motor neuropsychological scores was assessed by correlation analysis. Results: PD group showed a significantly decreased CBF in the right cerebelum_crus2, the left middle frontal gyrus (MFG), the triangle inferior frontal gyrus (IFG_Tri), the left frontal medial orbital gyrus (FG_Med_Orb) and the left caudate nucleus (CN) compared with the HC group (P < 0.05). Besides the above regions, the left supplementary motor area (SMA), the right thalamus had decreased CBF in the PPS group compared with the HC group (P < 0.05). PPS group had lower CBF value in the left MFG, the left IFG_Tri, the left CN, the left SMA, and the right thalamus compared with the PD group (P < 0.05). CBFs in left IFG_Tri, the left CN, the left SMA, and the right thalamus had moderate to high capacity in discriminating between PD and PPS patients (AUC 0.719-0.831). The CBF was positively correlated with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in PD patients, while positively correlated with the MMSE, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) scores in PPS patients (P < 0.05). Conclusion: PD and PPS patients have certain discriminative patterns of reduced CBFs, which can be used as a surrogate marker for differential diagnosis.

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“…However, it is not widely available and suffers from shortcomings of high cost and radiation hazards [12,13]. Besides structural MRI, functional MRI has additional value for differential diagnosis [14][15][16][17][18]. Among these functional imaging, arterial spin labeling (ASL)-based perfusion-weighted imaging is a novel, noninvasive method that does not require the injection of contrast agent.…”

Section: Introductionmentioning

confidence: 99%

Discriminative Pattern of Reduced Cerebral Blood Flow in Parkinson's Disease and Parkinsonism-Plus Syndrome: an ASL-MRI study

Cheng

Guo

et al. 2020

Preprint

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Background: Accurate identification of Parkinson's disease (PD) and Parkinsonism-Plus syndrome (PPS), especially in the early stage of the disease, is very important. The purpose of this study was to investigate the discriminative spatial pattern of cerebral blood flow (CBF) between patients with PD and PPS.Methods: Arterial spin labeling (ASL) perfusion-weighted imaging was performed in 20 patients with PD (mean age 56.35±7.56 years), 16 patients with PPS (mean age 59.62±6.89 years), and 17 healthy controls (HCs, mean age 54.17±6.58 years). Voxel-wise comparison of the CBF was performed among PD, PPS and HC groups. The receiver operating characteristic (ROC) curve was used to evaluate the performance of CBF in discriminating between PD and PPS.Results: PD group showed a significantly decreased CBF in the right cerebelum_crus2, the left middle frontal gyrus (MFG), the triangle inferior frontal gyrus (IFG_Tri), the left frontal medial orbital gyrus (FG_Med_Orb) and the left caudate nucleus (CN) compared with the HC group (P < 0.05). Besides the above regions, the left supplementary motor area (SMA), the right thalamus had decreased CBF in the PPS group compared with the HC group (P < 0.05). PPS group had lower CBF value in the left MFG, the left IFG_Tri, the left CN, the left SMA, and the right thalamus compared with the PD group (P < 0.05). CBFs in left IFG_Tri, the left CN, the left SMA, and the right thalamus had moderate to high capacity in discriminating between PD and PPS patients (AUC 0.719-0.831).Conclusion: PD and PPS patients have certain discriminative patterns of reduced CBFs, which can be used as a surrogate marker for differential diagnosis.

show abstract

Differential diagnosis of multiple system atrophy with predominant parkinsonism and Parkinson's disease using neural networks

Cited by 21 publications

References 21 publications

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

Discriminative pattern of reduced cerebral blood flow in Parkinson’s disease and Parkinsonism-Plus syndrome: an ASL-MRI study

Discriminative Pattern of Reduced Cerebral Blood Flow in Parkinson's Disease and Parkinsonism-Plus Syndrome: an ASL-MRI study

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