Differential diagnosis of lymphocytic interstitial pneumonia and malignant lymphoma on high-resolution CT.

Honda, Osamu; Johkoh, Takeshi; Tomiyama, Noriyuki; Maeda, Munehiro; Mihara, Naoki; Higashi, Masahiro; Hamada, Seiki; Naito, Hiroyuki; Yamamoto, Satoru; Nakamura, Hajime

doi:10.2214/ajr.173.1.10397102

Cited by 114 publications

(73 citation statements)

References 17 publications

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“…5) In the present case, chest CT showed ground-grass shadows and thickening of peribronchovascular interstitium without nodule and pleural effusion.…”

Section: Discussionsupporting

confidence: 47%

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A Case of Diffuse Large B-cell Lymphoma of the Lung Demonstrating Diffuse Ground-glass Shadows

Ogata-Suetsugu

Maeyama

Takeshita

et al. 2011

ATCS

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We report a case of 77-year-old woman suffering from breathlessness on exertion and dry cough. Chest computed tomography (CT) showed diffuse ground-glass shadows. A videoassisted thoracoscopic lung biopsy resulted in the diagnosis of diffuse large B-cell lymphoma (DLBCL). Gene rearrangement analysis using polymerase chain reaction (PCR) technique was performed on the cells in bronchoalveolar lavage (BAL) fluid, and showed the clonality of the immunoglobulin heavy chain (IgH) gene, supporting the diagnosis. DLBCL should be considered in the differential diagnosis of diffuse ground-glass shadows in the chest CT, and gene rearrangement analysis may have an impact on the diagnosis of pulmonary DLBCL.

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“…5) In the present case, chest CT showed ground-grass shadows and thickening of peribronchovascular interstitium without nodule and pleural effusion.…”

Section: Discussionsupporting

confidence: 47%

“…Regarding LIP, Honda et al reported the difference between LIP and malignant lymphoma on High-resolution CT. 5) Cysts and small nodules are common findings in patients with LIP.…”

Section: Discussionmentioning

confidence: 99%

A Case of Diffuse Large B-cell Lymphoma of the Lung Demonstrating Diffuse Ground-glass Shadows

Ogata-Suetsugu

Maeyama

Takeshita

et al. 2011

ATCS

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“…Therefore, we also suspected that the pulmonary findings in this case could possibly be due to LIP and/or FB based on the presence of multiple pulmonary cysts, ground-glass attenuation and small nodules. Collectively, CT findings of multiple thinwalled cysts are common in patients with LIP and/or FB and rare in those with p-MALT lymphoma (6). It has been reported that chronic inflammation and autoimmune disorders, such as Sjögren's syndrome and rheumatoid arthritis, are risk factors for MALT lymphoma (15).…”

Section: Discussionmentioning

confidence: 99%

“…CT findings of multiple thin-walled cysts are often observed in patients with lymphocytic interstitial pneumonia (LIP) or follicular bronchiolitis (FB) and are useful in distinguishing p-MALT lymphoma (6). We herein report a rare case of p-MALT lymphoma with multiple cystic lesions and present a review of the literature.…”

Section: Introductionmentioning

confidence: 97%

Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Multiple Thin-walled Pulmonary Cysts: A Case Report and Review of the Literature

et al. 2013

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We herein report a rare case of pulmonary mucosa-associated lymphoid tissue (p-MALT) lymphoma with multiple cystic lesions. A previously healthy 58-year-old Japanese woman visited our hospital for an evaluation of abnormal chest computed tomography (CT) findings. Chest CT revealed multiple cystic lesions in both lungs, and she was diagnosed as having p-MALT lymphoma based on the pathological findings. The patient had no underlying autoimmune diseases. She has not received any chemotherapy and has been stable for two years. This case suggests that, although rare, the possibility of p-MALT lymphoma should be considered in patients with multiple cystic lung diseases.

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“…Aspecto de massas com base pleural foi descrito em 32% dos casos de Lewis et al (5) . Alguns pacientes apresentam também associação das consolidações com áreas de atenuação em vidro fosco (8) . Nos linfomas primários as consolidações podem ter curso indolente, permanecendo inalteradas por anos (4) .…”

Section: Discussionunclassified

Linfomas Pulmonares: Correlação Da Tomografia Computadorizada De Alta Resolução Com a Anatomopatologia

et al. 2002

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Neste trabalho são descritos os aspectos tomográficos de alta resolução dos linfomas pulmonares e feita correlação com os achados anatomopatológicos. Com este objetivo, foram revisados as tomografias computadorizadas de alta resolução do tórax e os dados histopatológicos de dez pacientes com diagnóstico confirmado de linfoma não-Hodgkin ou de doença de Hodgkin. Os resultados obtidos foram confrontados com os descritos na literatura. Os achados radiológicos mais comumente vistos neste estudo foram as consolidações parenquimatosas, localizadas, com broncogramas aéreos de permeio (n = 8). Em menor freqüência, foram encontrados múltiplos nódulos parenquimatosos (n = 4), espessamento peribroncovascular (n = 3) e opacidades em vidro fosco (n = 2). Na correlação com a anatomia patológica, as consolidações corresponderam a preenchimento alveolar por células neoplásicas, o espessamento peribroncovascular se deveu a infiltração das bainhas peribroncovasculares por células linfomatosas e a atenuação em vidro fosco se associou com infiltração dos septos alveolares por tais células. Unitermos: Linfomas pulmonares. Tomografia computadorizada de alta resolução. Anatomopatologia.Pulmonary lymphomas: high-resolution computed tomography and anatomopathological correlation. This paper describes the high-resolution computed tomography and anatomopathological findings of pulmonary lymphomas. We studied the chest high-resolution computed tomographies and histopathological data of 10 patients with biopsy-proven non-Hodgkin's or Hodgkin's disease. The most common radiologic findings in this series were areas of consolidation with air-bronchogram (n = 8). Other findings included multiple pulmonary nodules (n = 4), thickening of bronchovascular bundles (n = 3) and foci of groundglass attenuation (n = 2). The present series results are consistent with the current available literature on radiographic appearance of the disease. The pathological correspondence of the areas of airspace consolidation was alveolar filling by neoplastic cells, the thickening of bronchovascular bundles was secondary to lymphomatous cells infiltrates, and the areas of ground-glass attenuation corresponded to alveolar septal infiltration by these cells. INTRODUÇÃOO envolvimento linfomatoso do pulmão pode ser classificado em quatro categorias (1) : linfoma pulmonar primário, linfoma pulmonar secundário ou recorrente, linfoma em pacientes com alterações linfoproliferativas pós-transplante e linfomas relacionados à síndrome da imunodeficiên-cia adquirida (SIDA).Em relação aos tipos histológicos, os linfomas de Hodgkin (LH), caracterizados pela presença de células de Reed-Sternberg, têm quatro tipos básicos (2) : predomí-nio linfocítico, esclerose nodular, celularidade mista e depleção linfocítica. Os linfomas não-Hodgkin (LNH) são classificados em baixo grau, grau intermediário e alto grau, havendo diversos subgrupos em cada uma dessas categorias (2) . Linfomas pulmonares primários são linfomas extranodais raros, em geral do tipo não-Hodgkin. Tendem a permanecer loca...

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Differential diagnosis of lymphocytic interstitial pneumonia and malignant lymphoma on high-resolution CT.

Cited by 114 publications

References 17 publications

A Case of Diffuse Large B-cell Lymphoma of the Lung Demonstrating Diffuse Ground-glass Shadows

A Case of Diffuse Large B-cell Lymphoma of the Lung Demonstrating Diffuse Ground-glass Shadows

Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Multiple Thin-walled Pulmonary Cysts: A Case Report and Review of the Literature

Linfomas Pulmonares: Correlação Da Tomografia Computadorizada De Alta Resolução Com a Anatomopatologia

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