Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Multiple Thin-walled Pulmonary Cysts: A Case Report and Review of the Literature

Noguchi, Shingo; Yatera, Kazuhiro; Kido, Takashi; Ogoshi, Takaaki; Nagata, Shuya; Nishida, Chinatsu; Yamasaki, Kei; Kawanami, Toshinori; Kawanami, Yukiko; Ishimoto, Hiroshi; Mukae, Hiroshi

doi:10.2169/internalmedicine.52.0377

Cited by 16 publications

(12 citation statements)

References 16 publications

(19 reference statements)

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“…Chronic cough, sputum, progressive dyspnoea, fatigability, fever, night sweats and weight loss are the most common manifestations. Imagiologic findings are generally nonspecific, such as single or multiple nodules, consolidation areas, bronchiectasis, bronchiolitis phenomena or diffuse interstitial lung disease 2,4,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Extranodal marginal zone B cell lymphoma (MZL) is a low grade B cell lymphoma of mucosa associated lymphoid tissue (MALT). Primary pulmonary MALT, also called bronchial-associated lymphoid tissue (BALT), accounts for 0.5-1% of all malignant lung tumours and about 90% of all lung lymphomas 1,2 . BALT represents 15% of all MALT lymphomas 1,3 .…”

Section: Introductionmentioning

confidence: 99%

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Case Report: Bronchial associated lymphoid tissue lymphoma and Mycobacterium chelonae

et al. 2016

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Bronchial-associated lymphoid tissue (BALT) lymphoma is a rare condition that accounts for only 0.5-1% of all malignant lung tumours. We present the case of a 66-year-old man admitted with pneumonia for further study and therapy. Initially the sputum was positive for Mycobacterium tuberculosis complex using polymerase chain reaction technology and antituberculous therapy was initiated. Due to the lack of imagiological improvement, the patient underwent a pulmonary transthoracic biopsy that revealed BALT lymphoma. Months later, Mycobacterium chelonae was identified and specific therapy was started with clarithromycin and tobramycin, before initiating BALT treatment with cyclophosphamide. There are only a few documented cases of BALT lymphoma associated with Mycobacterium. In this case M. chelonae might have been present before BALT lymphoma, contributing as an immunologic stimulus, or appeared afterwards, in the neoplastic context. BALT has an indolent evolution with a good prognosis and that is the reason why some experts favour a “watchful waiting” option.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Case Report: Bronchial associated lymphoid tissue lymphoma and Mycobacterium chelonae

et al. 2016

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“…Chłoniak typu MALT należy do przewlekłych rozrostów limfoidalnych wywodzących się z limfocytów B, z niskim stopniem złośliwości, który po raz pierwszy został opisany w 1983 roku przez Isaacsona i Wrighta [1]. W klasyfikacji Światowej Organizacji Zdrowia (WHO, World Health Organization) nowotworów układu chłonnego z 2008 roku zaliczany jest do chłoniaków strefy brzeżnej (MZL, marginal zone lymphomas) o podtypie chłoniaka pozawęzłowego (extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue) [2].…”

Section: Wstępunclassified

“…Według danych z piśmiennictwa analiza retrospektywna opisanych dotychczas przypadków z lat 1991−2008 wykazała, że 63,2% pacjentów paliło tytoń, a 11,5% przebyło gruźlicę [6]. Opisano również, że choroby autoimmunologiczne, takie jak zespół Sjögrena czy reumatoidalne zapalenie stawów, stanowią czynniki ryzyka wystąpienia chłoniaka typu MALT [1]. W opisanym w niniejszej pracy przypadku wykluczono występowanie chorób autoimmunologicznych i gruźlicy, a jedynym czynnikiem mogącym wywołać chłoniaka typu MALT było długotrwałe palenie tytoniu.…”

Section: Omówienieunclassified

Chłoniak Typu MALT o Lokalizacji Płucnej—Opis Przypadku

Kubisa¹,

Bocheńska²,

Piotrowska³

et al. 2015

Advances in Respiratory Medicine

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Primary pulmonary lymphoma accounts only 0,5% of all primary lung neoplasms. Mucosa-associated lymphoid tissue (MALT) lymphoma is a low grade B-cell extranodal lymphoma. It is a quite infrequent entity, however it constitutes from 72% to 90% of all pulmonary lung lymphomas. Long-term stimulation of bronchus-associated lymphoid tissue by antigens, smoking, inflammatory disorders or autoimmune diseases are thought to be leading to the development of MALT lymphoma. We present the case of primary pulmonary mucosa-associated lymphoid tissue lymphoma. A 76-year-old man with a history of heavy smoking (22.5 pack years) was admitted to the hospital for a further diagnostics of an abnormal finding in the right lung visualized on the chest X-ray. The diagnostic process, including imagining studies did not reveal the etiology of a lesion in the right lung. The patient was qualified for surgical diagnostics. The histological finding confirmed extranodal marginal low-grade B-cell lymphoma of mucosa -associated lymphoid tissue.

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“…Patients with MALT lymphoma may have nonspecific symptoms and can also be asymptomatic [2]. Chest computed tomography (CT) findings of MALT lymphomas occurring in the lung range from typical nodules or areas of consolidation to findings that are extremely rare, such as pure ground-glass opacities (GGOs) [2]. Here, we report a patient with growth and many GGOs.…”

Section: Introductionmentioning

confidence: 99%

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report

Ding

Makino

Koezuka

et al. 2017

J Cardiothorac Surg

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BackgroundPrimary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B cell lymphoma that is a type of non-Hodgkin lymphoma and a type of primary pulmonary malignant lymphoma. MALT lymphomas affecting the lung show various findings on chest computed tomography, which range from typical nodules or areas of consolidation to findings that are extremely rare in pulmonary MALT lymphomas, such as pure ground-glass opacities throughout the lung.Case presentationA 35-year-old woman was found to have a few shadows with ground glass opacities on chest computed tomography (CT) in 2012. A shadow in right S10 that was initially very small increased in size over time, and was 14 × 8 mm in 2015. Other shadows also appeared. Because lung adenocarcinoma was suspected, the patient underwent video-assisted thoracoscopic surgery with a right wedge resection of the lower lobe that included the largest nodule in S10 and other nodules. Histopathological examination of the right S10 and other lesions revealed small- or medium-sized lymphocyte-like cells that were located in the alveolar interseptal spaces. The alveolar walls remained intact. Immunohistochemical staining showed that tumor cells were positive for CD20, CD79a, and BCL2 expression. The lesions were diagnosed as extranodal marginal zone B-cell lymphoma of MALT.ConclusionsWe think that the ground glass opacities on CT were accounted for by MALT lesions that contained intact alveolar air spaces. The patient has remained well during 12 months of follow up after surgery. Although she did not receive chemotherapy because the MALT lymphoma lesions have been stable without progression, the patient is kept under close observation because of potential progression of the disease.

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Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Multiple Thin-walled Pulmonary Cysts: A Case Report and Review of the Literature

Cited by 16 publications

References 16 publications

Case Report: Bronchial associated lymphoid tissue lymphoma and Mycobacterium chelonae

Case Report: Bronchial associated lymphoid tissue lymphoma and Mycobacterium chelonae

Chłoniak Typu MALT o Lokalizacji Płucnej—Opis Przypadku

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report

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