Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS

Dermane, Affo; Kpegba, Kafui; Eloh, Kodjo; Osei‐Safo, Dorcas; Amewu, Richard K.; Caboni, Pierluigi

doi:10.1016/j.rechem.2020.100052

Cited by 10 publications

(6 citation statements)

References 25 publications

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“…Eneh et al; 2019 [38] The qualitative phytochemical screening revealed the presence of alkaloids; tannins; saponins; terpenes; flavonoids; cardiac glycosides and anthraquinones in N Laevis leaf extract. Dermane et al; 2020 [36] The use of high-performance liquid chromatography method showed to be suitable for the determination of withasomnine; newbouldine; and lapachol derivatives together with other known bioactive compounds like phytosterols and triterpenoids. Ndidi et al; 2020 [43] The phytochemical analysis shows the presence of Phenols; flavonoids; glycosides; tanins; oxalate; terpenoids; anthraquinolones; alkaloids and tanins in both methanolic and aqueous extracts of N. Laevis.…”

Section: Osigwe Et Al;mentioning

confidence: 99%

Newbouldia’s Laevis biological effects against metabolic syndrome components: A review

Bwegne¹,

Ayina²,

Pagnangdé³

et al. 2022

World J. Adv. Res. Rev.

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This study focused on a review of existing data on Newbouldia laevis and its potential effects on metabolic syndrome. Progressive changes in lifestyle that promote sedentary lifestyle, nutritional imbalances associated with excessive levels of refined sugars and fat that promote excess calories, and genetic factors have contributed significantly to the increase in cardiovascular disease, diabetes and the emergence of the concept of metabolic syndrome. Metabolic syndrome refers to an aggregation of factors that intervene, most often together, it is defined as a set of biological and clinical disorders whose metabolic aberrations are mainly: Insulin resistance and dysglycemia, obesity (general and abdominal), atherogenic dyslipidaemia, high blood pressure pro-inflammatory and prothrombotic states. The management of metabolic syndrome is very complex, because the components are associated differently in each patient due to the genetic susceptibility of each to develop one component over another, and the many environmental factors influencing the development of the pathology. The African continent is full of a great diversity of plant species, most of which are used by people as medicines to solve their health problems, because they are readily available. The African hyssop or Newbouldia laevis is a plant in the family Bignoniaceae. The qualitative phytochemical screening revealed the presence of alkaloids, tannins, saponins, terpenes, flavonoids, and cardiac glycosides anthraquinones in Newbouldia laevis leaf extract. Several therapeutic properties have been attributed to the plant Newbouldia laevis including anti-hyperglycemic, cardio-protective and hypotensive activity, body weight reduction, anti-inflammatory, antithrombotic, hepato-protective, antiparasitic, antibiotic. Herbal medicine is an alternative way to treat metabolic syndrome, and its importance is growing.

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Section: Osigwe Et Al;mentioning

confidence: 99%

Newbouldia’s Laevis biological effects against metabolic syndrome components: A review

Bwegne¹,

Ayina²,

Pagnangdé³

et al. 2022

World J. Adv. Res. Rev.

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“…Newbouldia laevis is another tropical African angiosperm used to mark property boundaries. Its folk medicinal use is attributed to speci c chemical substances (Dermane et al 2020). Kuete et al (2007) identi ed ten compounds in its root bark extract with potent antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking and pharmacokinetic studies of bioactive compounds from medicinal plants as promising inhibitory agents against Mycobacterium tuberculosis Enoyl-acyl carrier protein (ACP)-reductase (InhA)

Fawibe,

Lawal,

Mustafa

et al. 2023

Preprint

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Tuberculosis (TB) is a significant global public health challenge. Targeting enoyl-acyl carrier protein (ACP) reductase (InhA), an enzyme involved in mycolic acid biosynthesis, is a promising path to discovering an effective treatment for tuberculosis. This study assessed the inhibitory potential of bioactive compounds from four medicinal plants (Garcinia kola, Moringa oleifera, Newbouldia laevis, and Ocimum gratissimum) and control drugs (Isoniazid and Ethionamide) against InhA. Molecular docking and computational tools were used to evaluate the binding affinities and interactions with InhA's active site. Drug-likeness, binding affinities, bioactivity, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) attributes were determined using online tools. Ten out of twenty-three bioactive compounds studied were screened out due to their violation of Lipinski's, Ghose's, Veber's, Egan's, or Muegge's rules. Interestingly, the remaining thirteen compounds showed stronger binding affinities with InhA than those of the control drugs, depicting them as potential anti-tuberculosis drugs. The binding energy of the bioactive compounds ranged from − 8.0 to -9.5 kcal/mol while those of Isoniazid and Ethionamide, were 6.1 kcal/mol and − 6.0 kcal/mol, respectively. Also, the compounds exhibited hydrogen bonds, hydrophobic, and π stacking interactions with the active site residues of the protein; hence, contributing to their potential as antituberculosis agents. The ADMET property of each of the hit ligands predicted its ability to effectively reach and remain at the target protein to exert its therapeutic influence. The study depicts that the screened bioactive compounds exhibited more favorable docking interactions with the target protein than the control drugs, potentially contributing to tuberculosis treatment.

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“…Also, it is used as ornamental plant (Burkill, 1985). Although, there are reports on the phytochemical constituents of many tropical medicinal plants and their efficacy in treatment of various ailment (Kang, 2021), however, report on phytochemical constituents of Newbouldia laevis is scanty (Dermane et al, 2020). The preclinical investigations on Newbouldia laevis using laboratory animals revealed its protective property against toxicity produced by heavy metals (Ogbe et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects of Newboldia laevis (ogirisi) on mercury chloride – induced kidney damage in adult male Wistar rats

2023

JoSVAS

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Drug-induced injury is a key cause of kidney disease. Mercuric chloride, an antineoplastic agent used for treating various malignancies can cause kidney injury and induce nephrotoxicity. This study was to determine the effects of Newbouldia laevis on mercury chloride- induced kidney damage in adult male Wistar rats. Twenty-five adult male Wistar rats weighing between 110 – 200g were used for this study. The animals were allocated to five groups: A to E with five rats per group. Group A served as the control group and was administered 1ml of distilled water daily. Group B received a low dose of Newbouldia laevis (200mg/kg body weight) for 28 days along with Mercuric chloride (10mg/kg body weight). Group C received an intermediate dose of Newbouldia laevis (400mg/kg) for 28 days with Mercuric chloride (10mg/kg). Group D received a high dose of Newbouldia laevis (800mg/kg) for 28 days with Mercuric chloride (10mg/kg). Group E received only Mercuric chloride (10mg/kg) daily for 28 days. Rats in each group were allowed unrestricted access to water and feed during the experiment. Intracardial collection of blood from the Wistar rats was carried out in each group and the kidney function were assessed. The kidney tissues were processed for light microscopy study. Group A kidney tissues showed normal tubules, glomeruli, and interstitial spaces. Group E showed mercuric chloride-induced kidney injury: perivascular infiltrates of inflammatory cells; patchy tubular necrosis. Group D showed amelioration of the damages caused by Mercuric chloride. It can be concluded that Newbouldia laevis ameliorated Mercuric chloride – induced kidney damage in dose-dependent-pattern.

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Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS

Cited by 10 publications

References 25 publications

Newbouldia’s Laevis biological effects against metabolic syndrome components: A review

Newbouldia’s Laevis biological effects against metabolic syndrome components: A review

Molecular docking and pharmacokinetic studies of bioactive compounds from medicinal plants as promising inhibitory agents against Mycobacterium tuberculosis Enoyl-acyl carrier protein (ACP)-reductase (InhA)

Effects of Newboldia laevis (ogirisi) on mercury chloride – induced kidney damage in adult male Wistar rats

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