Differential collagen expression in kidney and heart during hypertension

Abstract

The aim of the present study was to investigate the immunohistochemical expression of selected collagen types, namely collagen types I and V and procollagen type III in the renal parenchyma and interstitium and in the myocardium of spontaneously hypertensive rats. MATERIAL AND METHODS: For the present study, we used two age groups of 6-and 12-month-old spontaneously hypertensive rats. An immunohistochemical analysis was conducted with monoclonal antibodies against collagen types I and V and procollagen type III. A semi-quantitative analysis of immunostaining intensity was conducted with the Image J software. RESULTS: In the kidney, all three molecules showed higher expression at the age of 12 months, which was particularly notable for procollagen type III and collagen type V, which stained as highly-positive. In the myocardium, the immunoreactivity of collagen types I and V was stronger in 12-month-old animals, while that of procollagen type III did not change substantially. CONCLUSION: The present study suggests a role of collagen types III and V in hypertensive kidney disease, while also establishing the role of increased expression of collagen types I and V in adverse myocardial remodeling (Tab. 1, Fig. 2, Ref. 48).

Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm‐Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice

“…As such, their detection is of special relevance in retinal pathologies such as retinal injuries, [47] diabetic retinopathy, [48,49] or age-related macular degeneration. [50] Furthermore, hypertension can modify the turnover and expression of collagen I and III, favoring the fibrotic process in different organs [51] ; and collagen IV has been implicated in the development of microvascular complications. [52] Therefore, the regulation of collagen isoforms, especially type IV collagen, by nutraceutical agents might be a useful target to reduce the risk of hypertension-driven retinal vascular damage.…”

A set of urinary peptides can predict early renal damage in primary hypertension

“…Although we only found 23 urinary peptides in our sample, their distribution pattern and corresponding proteins exhibited a high level of consistency with CKD273, primarily Collagen a-1 (I) chain and Collagen a-1 (III) chain. Recent studies have demonstrated that collagen types I, V, and procollagen type III are significantly increased in the renal tissue of hypertensive rats [31].…”

Mechanisms of inflammation modulation by different immune cells in hypertensive nephropathy

“…Notably, type I, III, V, VI, VII, and XV collagen are all expressed in the kidney under physiological conditions. The expression of type III procollagen and type V collagen is significantly increased in spontaneously hypertensive rats(SHR) kidneys, suggesting that these collagens play a role in hypertension-induced renal fibrosis ( 52 ). Further, complement C3 expression was significantly increased in the renal mesenchymal tissues of SHR, inducing the synthesis and overgrowth of mesenchymal cells ( 53 ).…”