Differential Clinical Outcome of Dengue Infection Among Patients With and Without HIV Infection: A Matched Case–Control Study

Pang, Junxiong; Thein, Tun-Linn; Lye, David C.; Leo, Yee‐Sin

doi:10.4269/ajtmh.15-0031

Cited by 23 publications

(16 citation statements)

References 40 publications

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“…To date, six clinical reports have described the clinical presentations of dengue infection in HIV-1-infected patients. [8][9][10][11][12][13] These reports suggest that HIV/DENV coinfection results in a benign clinical progression of dengue disease, as well as suppression of HIV-1 replication during the acute phase of dengue infection. [8][9][10] Here in we report a case of DENV-1 infection in an HIV-1-positive patient chronically infected with HBV in Colima State, Mexico, an endemic tropical region for DENV transmission.…”

Section: Introductionmentioning

confidence: 99%

Dengue Infection in a Human Immunodeficiency Virus-1 Positive Patient Chronically Infected with Hepatitis B Virus in Western Mexico

Delgado‐Enciso

Espinoza‐Gómez

Ochoa-Jiménez

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. Human immunodeficiency virus (HIV) and dengue coinfection has not been extensively studied. We report herein a case of dengue serotype 1 infection in an HIV-1-positive patient coinfected with hepatitis B virus (HBV) in Colima State, Mexico. CD4 + cells and HIV-1 viremia remained at normal levels, and no severe complications were observed during this multiple viral infection. The alanine transaminase and aspartate transaminase values were elevated before and during dengue infection. Surprisingly, these parameters were significantly reduced 2 months later. Because of the lack of evidence regarding this multiple viral interaction, further research is required to understand the biologic and clinical course of dengue infection in HIV-1/HBV coinfected patients, especially in tropical regions where dengue virus transmission is highly active.

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Section: Introductionmentioning

confidence: 99%

Dengue Infection in a Human Immunodeficiency Virus-1 Positive Patient Chronically Infected with Hepatitis B Virus in Western Mexico

Delgado‐Enciso

Espinoza‐Gómez

Ochoa-Jiménez

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…More recently, Hotzz et.al., reported that DENV infection in ART-treated HIV patients was associated with reduced vascular instability and liver damage 26 . However, coinfected patients could have severe dengue outcomes 27 .…”

Section: Discussionmentioning

confidence: 99%

Apoptosis characterization in mononuclear blood leukocytes of HIV patients during dengue acute disease

Torrentes-Carvalho

Sánchez‐Arcila

Azamor

et al. 2020

Sci Rep

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Dengue virus (DenV) co-circulation in Brazil represents a challenge for treatment and vaccine development. Despite public health impact, the occurrence of coinfections with other viruses is a common event. Increased T cell activation and altered inflammatory response are found during DENV coinfection with Human Immunodeficiency Virus (HIV) impacting HIV-pathogenesis. Even with Antiretroviral therapy (ARt), HiV-treated patients had chronic immune activation and lymphocyte apoptosis. However, apoptotic mechanisms have not been investigated during coinfection with DenV. our attention was attracted to apoptotic cell markers expressions in pBMcs from DenV and DenV/ HIV coinfected patients. We found CD4/CD8 ratio inversion in most coinfected patients. CD4 T and CD8 T-cell subsets from DENV and DENV/HIV groups expressed low levels of anti-apoptotic protein Bcl-2. Furthermore, CD8 CD95 double positive cells frequency expressing low levels of Bcl-2 were significantly higher in these patients. Additionally, the density of Bcl-2 on classical monocytes (CD14 ++ CD16 − ) was significantly lower during DENV infection. Upregulation of pro-apoptotic proteins and anti-apoptotic proteins were found in DenV and DenV/HiV, while catalase, an antioxidant protein, was upregulated mainly in DENV/HIV coinfection. These findings provide evidence of apoptosis triggering during DenV/HiV coinfection, which may contribute to knowledge of immunological response during DenV acute infection in HiV-patients treated with ARt.Dengue virus (DENV) and Human Immunodeficiency Virus (HIV) infections are currently a major public health concern in Brazil. Dengue is caused by any one of four DENV (1-4) serotypes spread by mosquitoes of aedes genus. DENV causes an acute febrile illness of a broad clinical spectrum presenting both asymptomatic and symptomatic forms that can evolve with severe and potentially fatal condition 1 . The hallmark of most serious clinical conditions is the vascular permeability increase that causes plasma leakage, leading to shock and death. Acquired Immunodeficiency Sydrome (AIDS) (is still considered an important cause of morbidity and mortality in the world. HIV infects CD4 T-cells, monocytes/macrophages and to a lesser extent in dendritic cells leading to progressive CD4 T-cell depletion and consequently pronounced immunosuppression in the absence of effective antiretroviral therapy (ART) 2 .Apoptosis, also called type I cell death, is a regulated process of cell death highly conserved among mammals and comprises a controlled self-destruction process to eliminate damaged, neoplastic and virus-infected cells 3 . Apoptosis program regulation is determined by interactions of three members of B-cell lymphoma-2 family proteins (Bcl-2): Bcl-2 homologous 3 (BH3)-only proteins, Bcl-2 proteins and Bcl-2 associated X protein (Bax)/Bcl-2 homologous antagonist/killer (Bak) effectors. It can be triggered by extrinsic [death receptors like p55 tumor necrosis factor TNF receptor-TNFRI, Fas/CD95, TRAIL/APO2-L (TNF-related apoptosis-inducing li...

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“…However, the influence of these infections on the outcome of HIV infection is not well determined (11) . DENV infection causes a transient reduction in HIV load, apparently without impact on the clinical outcome of dengue fever or AIDS (12) . However, there is no information about the interaction of HIV with other arboviruses.…”

Section: Discussionmentioning

confidence: 99%

Mayaro fever in an HIV-infected patient suspected of having Chikungunya fever

Estofolete

Mota

Vedovello

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Arboviruses impose a serious threat to public health services. We report a case of a patient returning from a work trip to the Amazon basin with myalgia, arthralgia, fever, and headache. During this travel, the patient visited riverside communities. Both dengue and Chikungunya fevers were first suspected, tested for, and excluded. Mayaro fever was then confirmed by reverse transcription polymerase chain reaction followed by next-generation sequencing and phylogenetic reconstruction. The increased awareness of physicians and consequent detection of Mayaro virus in this case was only possible due a previous surveillance program with specific health personnel training about these neglected arboviruses.

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Differential Clinical Outcome of Dengue Infection Among Patients With and Without HIV Infection: A Matched Case–Control Study

Cited by 23 publications

References 40 publications

Dengue Infection in a Human Immunodeficiency Virus-1 Positive Patient Chronically Infected with Hepatitis B Virus in Western Mexico

Dengue Infection in a Human Immunodeficiency Virus-1 Positive Patient Chronically Infected with Hepatitis B Virus in Western Mexico

Apoptosis characterization in mononuclear blood leukocytes of HIV patients during dengue acute disease

Mayaro fever in an HIV-infected patient suspected of having Chikungunya fever

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