Dengue Infection in a Human Immunodeficiency Virus-1 Positive Patient Chronically Infected with Hepatitis B Virus in Western Mexico

Abstract

Abstract. Human immunodeficiency virus (HIV) and dengue coinfection has not been extensively studied. We report herein a case of dengue serotype 1 infection in an HIV-1-positive patient coinfected with hepatitis B virus (HBV) in Colima State, Mexico. CD4 + cells and HIV-1 viremia remained at normal levels, and no severe complications were observed during this multiple viral infection. The alanine transaminase and aspartate transaminase values were elevated before and during dengue infection. Surprisingly, these parameters were significantly reduced 2 months later. Because of the lack of evidence regarding this multiple viral interaction, further research is required to understand the biologic and clinical course of dengue infection in HIV-1/HBV coinfected patients, especially in tropical regions where dengue virus transmission is highly active.

Dengue Virus Coinfection in Human Immunodeficiency Virus-1-Infected Patients on the West Coast of Mexico

“…These findings suggest that there was no significant HIV viral load behavior attributable to DENV infection during the study follow-up. Our results coincide with a previous report 11 in which HIV viremia remained at normal levels in a patient with a multiple HIV, DENV-1, and hepatitis B virus infection. Interestingly, a previous report suggests that HIV replication is transiently inhibited when there is a DENV-1 coinfection in peripheral blood mononuclear cells with no antiviral treatment.…”

“…3,4 Nevertheless, in the case of coinfections of certain flaviviruses, such as the GB virus C (GBV-C), hepatitis C virus, or dengue virus (DENV), a reduction of the HIV-1 viral load has been observed. [5][6][7] Despite the fact that HIV infection has a worldwide distribution and that extensive regions are endemic for DENV transmission, there are only seven reports on HIV/DENV coinfection, 6,[8][9][10][11][12][13] which describe 41 patients with this simultaneous infection.…”

Imported Arbovirus Infections in Spain, 2009–2018

“…However, other case reports reveal less favorable outcomes and even atypical presentations: a fatal pseudotumoral form of ZIKV meningoencephalitis in a heart transplant recipient has been reported (25). With respect to arbovirus infection in HIV-positive patients, data are scarce, although favorable outcomes have been reported (20,26,27). In a study of 43 HIV-positive patients with confirmed ZIKV infection, no hospitalizations, complications, or deaths were found, and CD4 cell counts and HIV viral load did not differ after ZIKV infection (28).…”