Differential behavioral effects of nicotine in adult male and female rats with a history of prenatal methamphetamine exposure

Rorabaugh, Boyd R.; Seeley, Sarah L.; Evans, Mary; Marengo, Christina; D’Souza, Manoranjan S.

doi:10.1016/j.neulet.2017.05.002

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…After completion of habituation infusions, nicotine-induced CTA was conducted as described previously over a period of 18 days (Sellings et al , 2008; D’Souza and Markou, 2014; Rorabaugh et al , 2017; Ward et al , 2018) (see Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…The goal of the current study was to evaluate the effect of direct infusions of the KOR agonist ±U50488 on the aversive effects of systemically administered nicotine. The aversive effects of nicotine were assessed using the nicotine-induced conditioned taste aversion (CTA) model, as described previously (Shoaib and Stolerman, 1995;Sellings et al, 2008;D'Souza and Markou, 2014;Rorabaugh et al, 2017;Ward et al, 2018). The effects of KOR activation in the NAcc core and VTA on the aversive effects of nicotine were assessed by bilaterally infusing the KOR agonist ±U50488 into these brain regions via cannulae implanted above these regions.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological activation of kappa opioid receptors in the nucleus accumbens core and ventral tegmental area increases the aversive effects of nicotine

Pham

Seeley

D’Souza

2022

Behavioural Pharmacology

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Aversive effects of nicotine play an important role in the development of nicotine dependence. However, neural substrates and/or brain regions that play a role in the aversive effects of nicotine have not been fully identified. Previous work done in our laboratory showed that systemic administration of kappa opioid receptors (KORs) agonist ±U50488 increased the aversive effects of nicotine. In this study, we assessed the effects of KOR activation in specific brain regions, namely, the nucleus accumbens (NAcc) core and ventral tegmental area (VTA) on the aversive effects of nicotine using the conditioned taste aversion model. Separate groups of Wistar rats were implanted with cannulae above either the NAcc core or the VTA. KOR agonist (±U50488) was bilaterally infused in the NAcc core (0, 0.3, and 3 ug/0.5 ul/side) or VTA (0, 0.3, 1.5, and 3 ug/0.5 ul/side) prior to receiving nicotine (0.4 mg/kg, base; s.c.) during conditioning. Bilateral infusion of the KOR agonist (3 ug/0.5 ul/side) in the NAcc core or the VTA increased the aversive effects of nicotine compared with respective saline controls. Together, these results suggest that pharmacological activation of the KORs in the NAcc core and VTA dose dependently modulate the aversive effects of nicotine. Because aversive effects of nicotine determine susceptibility to development of nicotine dependence, we can conclude that KOR activity in the NAcc and VTA after administration of nicotine may determine susceptibility to the development of nicotine dependence.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacological activation of kappa opioid receptors in the nucleus accumbens core and ventral tegmental area increases the aversive effects of nicotine

Pham

Seeley

D’Souza

2022

Behavioural Pharmacology

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“…This hypothesis is speculative as we are unaware of any studies that have compared the expression levels of DAT, the norepinephrine transporter (NET), or adrenergic and dopaminergic receptors in the developing male and female fetus. Understanding the mechanism by which prenatal exposure to methamphetamine or cocaine induces sex-dependent effects in the adult heart is complicated by the fact that some methamphetamine induced effects are found exclusively in males (52) and other effects occur exclusively in females (13,27). Similarly, prenatal cocaine produces some effects in only in male offspring (26, 28) and other effects that occur exclusively in female offspring (13,26).…”

Section: Methamphetaminementioning

confidence: 99%

Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?

Rorabaugh

2021

Front. Cardiovasc. Med.

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Prenatal exposure to an adverse uterine environment can have long lasting effects on adult offspring through DNA methylation, histone acetylation, and other epigenetic effects that alter gene expression and physiology. It is well-known that consumption of CNS stimulants such as caffeine, nicotine, amphetamines, and cocaine during pregnancy can adversely impact the offspring. However, most work in this area has focused on neurological and behavioral outcomes and has been limited to assessments in young offspring. The impact of prenatal exposure to these agents on the adult cardiovascular system has received relatively little attention. Evidence from both animal and human studies indicate that exposure to CNS stimulants during the gestational period can negatively impact the adult heart and vasculature, potentially leading to cardiovascular diseases later in life. This review discusses our current understanding of the impact of prenatal exposure to cocaine, methamphetamine, nicotine, and caffeine on the adult cardiovascular system.

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Effects of pharmacological manipulation of the kappa opioid receptors on the aversive effects of nicotine

Ward

Norman

D’Souza

2018

Behavioural Brain Research

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Differential behavioral effects of nicotine in adult male and female rats with a history of prenatal methamphetamine exposure

Cited by 5 publications

References 27 publications

Pharmacological activation of kappa opioid receptors in the nucleus accumbens core and ventral tegmental area increases the aversive effects of nicotine

Pharmacological activation of kappa opioid receptors in the nucleus accumbens core and ventral tegmental area increases the aversive effects of nicotine

Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?

Effects of pharmacological manipulation of the kappa opioid receptors on the aversive effects of nicotine

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