Differential associations of renal function with coronary and peripheral atherosclerosis

Zhao

Mediators of Inflammation

et al. 2012

Coronary artery disease (CAD) is an immune-mediated chronic inflammatory disease mainly caused by atherosclerosis. The aims of this study were to investigate the role of interleukin-27 (IL-27) in patients with CAD and the severity of coronary artery lesions, which was evaluated by Gensini score and to investigate the biosynthesis of IL-27 and oxidized low-density lipoprotein (ox-LDL)in vitrousing monocyte-derived dendritic cells (DCs). To this aim, plasma levels of IL-27, ox-LDL, and Gensini score were analyzed in patients with CAD (n=136) and normal subjects (controls,n=29). IL-27 concentration of the supernatant and the mRNA expression levels of p28 and ebi3, subunits of IL-27, from cultured immature DCs incubated with different concentrations of ox-LDL for 24 h were also analyzed. We found that circulating IL-27 levels were significantly elevated in patients with CAD than in controls (P<0.01), and positively correlated to ox-LDL and Gensini score. ox-LDL dose-dependently upregulated expression of both IL-27 protein and IL-27 (p28 and EBI3) mRNAin vitro,indicating that ox-LDL can stimulate DCs to produce IL-27. These results demonstrate that IL-27 might regulate the network of immunity and inflammation in the pathogenesis of atherosclerosis.

“…Gensini score was used to evaluate the severity of coronary artery stenosis from coronary angiography [20, 21]. The procedures were carried out as follows.…”

Section: Methodsmentioning

confidence: 99%

Elevated Circulating Interleukin-27 in Patients with Coronary Artery Disease Is Associated with Dendritic Cells, Oxidized Low-Density Lipoprotein, and Severity of Coronary Artery Stenosis

Zhao

Mediators of Inflammation

et al. 2012

“…6 Renal function is an important predictor of the presence and severity of angiographic CAD even in patients without severe renal impairment. 7 Early stages of CKD that are characterized by relatively preserved renal function are associated with increasing incidence of de novo and recurrent CVD events. 8 As GFR diminishes the prevalence and severity of CAD increases 9 .…”

mentioning

confidence: 99%

Impaired Renal Function is Associated with Severe Coronary Artery Disease in Chronic Stable Angina Patients

et al. 2014

Introduction:Cardiovascular diseases (CVD) are the number one cause of death globally. An estimated 17.3 million people died from CVDs in 2008, representing 30% of all global deaths. Of these deaths, an estimated 7.3 million were due to coronary heart disease. The number of people who die from CVDs will increase to reach 23.3 million by 2030. Coronary artery disease (CAD) is the most common cause of CVD mortality. 1 Cardiovascular diseases are becoming a significant burden on health care services in Bangladesh. 2 With the increase incidence of DM and hypertension, the prevalence of CKD is also alarmingly going up. CKD is strongly associated with accelerated CVDs and this association is independent of conventional risk factors such as DM, hypertension, dyslpidaemia 3 and caused by non-conventional risk factors such as anaemia, altered calcium-phosphorus metabolism, increased homocysteine level, inflammation and oxidative stress. 4 The glomerular filtration rate (GFR), determined by the Cockcroft-Gault equation, is a more precise and accurate way of estimating kidney function than measuring serum creatinine. 5 The United States National Kidney Foundation uses GFR rather than serum creatinine level to define renal dysfunction. National Kidney Foundation recommended estimated GFR for use in recognition, treatment and prevention of chronic kidney disease. It is considered as the overall best indicator of kidney function. Serum creatinine alone fails to identify many patients whose kidney function is reduced.

“…According to previous data, crude analysis revealed a moderate correlation between MDRD, a widely used estimate for GFR, and IMT [10][11][12] ; however, that association was entirely explained by the interplay between age, MDRD and IMT. Because MDRD equation systematically underestimates GFR in healthy individvals, we correlated IMT again with a revised MDRD equation (MDRD-1) but similar results were obtained 14) .…”

Section: Resultsmentioning

confidence: 86%

“…This was independent of traditional cardiovascular risk factors, such as age, BMI, smoking, hypertension, dyslipidemia and diabetes, in a population that included individuals with diabetes and CKD 11) . In contrast, Stamatelopoulos et al found no correlation between MDRD and IMT, although those authors observed an association between renal function and the extent of angiographic CAD in patients with CAD 12) ; however, the use of MDRD to estimate GFR is limited by various factors in this setting. Age and gender are used to calculate MDRD, but also have a substantial impact on the development of atherosclerosis.…”

Section: Introductionmentioning

confidence: 89%

Relation between Physiological Variation of Renal Function and Carotid Intima Media Thickness in Non-Diabetic Individuals

Bobbert

Mai

Fischer-Rosinský

et al. 2010

JAT

Aim: Moderate to severe renal insufficiency and albuminuria have been shown to be independent risk factors for atherosclerosis. However, the association between renal function and intima media thickness (IMT) in non-diabetic individuals is less clear. We therefore investigated the relation between renal function, established cardiovascular risk factors and carotid intima media thickness in non-diabetic individuals.