Impaired Renal Function is Associated with Severe Coronary Artery Disease in Chronic Stable Angina Patients

Abstract

Introduction:Cardiovascular diseases (CVD) are the number one cause of death globally. An estimated 17.3 million people died from CVDs in 2008, representing 30% of all global deaths. Of these deaths, an estimated 7.3 million were due to coronary heart disease. The number of people who die from CVDs will increase to reach 23.3 million by 2030. Coronary artery disease (CAD) is the most common cause of CVD mortality. 1 Cardiovascular diseases are becoming a significant burden on health care services in Bangladesh. 2 With the increase incidence of DM and hypertension, the prevalence of CKD is also alarmingly going up. CKD is strongly associated with accelerated CVDs and this association is independent of conventional risk factors such as DM, hypertension, dyslpidaemia 3 and caused by non-conventional risk factors such as anaemia, altered calcium-phosphorus metabolism, increased homocysteine level, inflammation and oxidative stress. 4 The glomerular filtration rate (GFR), determined by the Cockcroft-Gault equation, is a more precise and accurate way of estimating kidney function than measuring serum creatinine. 5 The United States National Kidney Foundation uses GFR rather than serum creatinine level to define renal dysfunction. National Kidney Foundation recommended estimated GFR for use in recognition, treatment and prevention of chronic kidney disease. It is considered as the overall best indicator of kidney function. Serum creatinine alone fails to identify many patients whose kidney function is reduced.

Association of GRACE Risk Score with Angiographic Severity of Coronary Artery Disease in patients with ST Elevation Myocardial Infarction

“…11 Additionally, renal function is also an important predictor of the presence and severity of angiographic CAD and creatinine level has an incremental value over traditional CAD risk factors. 12 The increased prevalence of atherosclerotic coronary stenoses with the progression of age in both sexes has also been reported before in autopsy studies. The rate of this increase was, however, more prominent in men between 30 and 49 years of age.…”