Differential arterial and venous endothelial redox responses to oxidative stress

Shrestha, Bandana; Prasai, Priya K.; Kaskas, Amir M.; Khanna, Ankur; Letchuman, Vijay; Letchuman, Sunjay; Alexander, J. Steven; Orr, A. Wayne; Woolard, Matthew D.; Pattillo, Christopher B.

doi:10.1111/micc.12486

Cited by 16 publications

(13 citation statements)

References 47 publications

(47 reference statements)

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“…Despite the luminal narrowing, a truly obstructive small vessel disease does not seem to be a relevant feature 5,22 . Importantly, previous work showed that the abnormal intramural small vessels closely co‐localize to the fibrotic scars 16 . Intramural small coronary arteries abnormalities consist mainly in medial hypertrophy, intimal proliferation, perimysial and intra‐arterial fibrosis, found in the interventricular septum.…”

Section: Coronary Microvascular Dysfunction In Hypertrophic Cardiomyomentioning

confidence: 98%

“…H 2 O 2 produced within mitochondria diffuses to the cytosol and sarcolemma, reaching extracellular space and leading to dilatation of vascular smooth muscle 15 . So, oxidative stress constitutes an important contributor to endothelial dysfunction, which culminates in the loss of endothelial‐dependent vasodilation and an increase in inflammation‐mediated cellular adhesion to the endothelium 16 . Furthermore, the presence of comorbidities that increase oxidative stress constitutes a further contributor to microvascular dysfunction.…”

Section: Coronary Physiologymentioning

confidence: 99%

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Coronary microvascular dysfunction in hypertrophic cardiomyopathy: Pathophysiology, assessment, and clinical impact

et al. 2020

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Myocardial ischemia constitutes one of the most important pathophysiological features in hypertrophic cardiomyopathy. Chronic and recurrent myocardial ischemia leads to fibrosis, which may culminate in myocardial dysfunction. Since the direct visualization of coronary microcirculation in vivo is not possible, its function must be studied indirectly. Invasive and noninvasive techniques allow microcirculatory dysfunction to be evaluated, including echocardiography, magnetic resonance, positron emission tomography, and cardiac catheterization. Blunted myocardial blood flow and coronary flow reserve have been suggested to associate with unfavorable prognosis. Microcirculatory dysfunction may be one additional important parameter to take into account for risk stratification beyond the conventional risk factors.

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Section: Coronary Microvascular Dysfunction In Hypertrophic Cardiomyomentioning

confidence: 98%

Section: Coronary Physiologymentioning

confidence: 99%

Coronary microvascular dysfunction in hypertrophic cardiomyopathy: Pathophysiology, assessment, and clinical impact

et al. 2020

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“…Recently, Shrestha et al [23] reported that VECs are more susceptible to the oxidative stress than AECs. These data support the opinion that oxidative stress plays a major role in the dysfunction of endothelial cells in patients treated with hemodialysis [24].…”

Section: Discussionmentioning

confidence: 99%

Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells

et al. 2018

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Background/aims: Hemodialysis causes the systemic inflammatory response, which may affect the function of endothelial cells. Methods: We studied the effect of the serum obtained after a hemodialysis session, compared to serum collected before the start of the treatment, on the gene expression and secretory activity of arterial endothelial cells (AECs) and venous endothelial cells (VECs) in in vitro culture. Results: Serum collected at the end of the hemodialysis session increased expression of the studied genes in VECs, and at the same time decreased their expression in AECs. Secretory activity was increased in VEC: (interleukin-6 [IL-6] +29%, p < 0.05, von Willebrand factor +23%, p < 0.02; tissue plasminogen activator [t-PA] +35%, p < 0.002, t-PA/plasminogen activator inhibitor-1 [PAI-1] ratio + 57%, p < 0.005). In AEC, synthesis of IL-6 and vascular endothelial growth factor were reduced (–36%, p < 0.02, –34%, p < 0.05, respectively) and the tPA/PAI-1 ratio was increased (+22%, p < 0.01). Conclusions: Hemodialysis induces the inflammatory, procoagulant, and profibrinolytic activity of VEC, whereas suppression of AEC is observed at the same time. Video Journal Club ‘Cappuccino with Claudio Ronco’ at https://www.karger.com/Journal/ArticleNews/223997?sponsor=52

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“…However, veins, especially postcapillary venules, are the main sites of leukocyte chemotaxis during inflammation [ 184 , 186 ]. In the oxidative stress response, the venous endothelium showed a significant increase in inflammation and a decrease in proliferative phenotype [ 187 ].…”

Section: Heterogeneity Of Vascular Endotheliummentioning

confidence: 99%

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

Cai

Liao

Xue

et al. 2021

Bioactive Materials

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Tissue-engineered vascular grafts (TEVGs) have enormous potential for vascular replacement therapy. However, thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs (<6 mm) after transplantation. Endothelialization of TEVGs is a key point to prevent thrombosis. Here, we discuss different types of endothelialization and different seed cells of tissue-engineered vascular grafts. Meanwhile, endothelial heterogeneity is also discussed. Based on it, we provide a new perspective for selecting suitable types of endothelialization and suitable seed cells to improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.

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Differential arterial and venous endothelial redox responses to oxidative stress

Cited by 16 publications

References 47 publications

Coronary microvascular dysfunction in hypertrophic cardiomyopathy: Pathophysiology, assessment, and clinical impact

Coronary microvascular dysfunction in hypertrophic cardiomyopathy: Pathophysiology, assessment, and clinical impact

Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

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