Differential actions of antidepressant treatments on cardiac autonomic alterations in depression: A prospective comparison

Udupa, Kaviraja; Thirthalli, Jagadisha; Sathyaprabha, T.N.; Kishore, K.R.; Raju, T.R.; Gangadhar, Bangalore N.

doi:10.1016/j.ajp.2011.02.006

Cited by 36 publications

(32 citation statements)

References 25 publications

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“…First, we did not exclude the medication effect. As antidepressants have different effects on HRV function,14,19-21) medication effects should be carefully controlled in future studies. Second, the age effect could not be strictly controlled, and HRV is known to be influenced by age and sex differences 43,44).…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study of Heart Rate Variability in Patients with Schizophrenia, Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder

Moon

Lee

Kim

et al. 2013

Clin Psychopharmacol Neurosci

103

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ObjectiveHeart rate variability (HRV) changes as a function of psychiatric illness. This study aimed to evaluate HRV among patients with various psychiatric disorders.MethodsThe present study recruited patients with schizophrenia (n=35), bipolar disorder (n=41), post-traumatic stress disorder (PTSD; n=34), or major depressive disorder (n=34) as well as healthy controls (n=27). The time-domain analysis (the standard deviation of all RR intervals [SDNN] and the square root of the mean squared differences of successive normal sinus intervals [RMSSD]), the frequency-domain analysis (very low frequency, low frequency [LF], high frequency [HF], and total power [TP]), and a non-linear complexity measure the approximate entropy were computed.ResultsSDNN and HF were significantly reduced in patients with schizophrenia compared with healthy controls. SDNN, RMSSD, TP, LF, and HF were significantly reduced in bipolar patients compared with healthy controls. HF was significantly reduced in PTSD patients compared with healthy controls.ConclusionOur findings indicate that HRV is not sufficiently powerful to discriminate among various psychiatric illnesses. However, our results suggest that HRV, particularly HF, could be used as a tool for discriminating between psychiatric patients and healthy controls.

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Section: Discussionmentioning

confidence: 99%

“…Research papers on this issue illustrate that changes in autonomic functioning depend on the type of antidepressant. Tricyclic antidepressants and serotonin-norepinephrine reuptake inhibitors tend to reduce HRV,14,19,20) whereas selective serotonin reuptake inhibitors (SSRIs) increase HRV 19,21)…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Heart Rate Variability in Patients with Schizophrenia, Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder

Moon

Lee

Kim

et al. 2013

Clin Psychopharmacol Neurosci

103

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“…Exclusion criteria included mental retardation, a schizophrenia spectrum disorder, or use of medications such as beta blockers, mood stabilizers, tricyclic antidepressants, or stimulants, which could alter physiological functioning. We did not exclude for selective serotonin reuptake inhibitor (SSRI) use, given experimental evidence that SSRIs do not alter RSA (Udupa et al, 2011). Control participants were excluded if they had any of the assessed psychiatric disorders (see below), or if they had ever engaged in SII.…”

Section: Methodsmentioning

confidence: 99%

Mechanisms of Contextual Risk for Adolescent Self-Injury: Invalidation and Conflict Escalation in Mother–Child Interactions

Crowell

Baucom

McCauley

et al. 2013

Journal of Clinical Child & Adolescent Psychology

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OBJECTIVE According to developmental theories of self-injury, both child characteristics and environmental contexts shape and maintain problematic behaviors. Although progress has been made toward identifying biological vulnerabilities to self-injury, mechanisms underlying psychosocial risk have received less attention. METHOD In the present study, we compared self-injuring adolescents (n=17) with typical controls (n=20) during a mother-child conflict discussion. Dyadic interactions were coded using both global and microanalytic systems, allowing for a highly detailed characterization of mother-child interactions. We also assessed resting state psychophysiological regulation, as indexed by respiratory sinus arrhythmia (RSA). RESULTS Global coding revealed that maternal invalidation was associated with adolescent anger. Furthermore, maternal invalidation and coerciveness were both related to adolescent opposition/defiance. Results from the microanalytic system indicated that self-injuring dyads were more likely to escalate conflict, suggesting a potential mechanism through which emotion dysregulation is shaped and maintained over time. Finally, mother and teen aversiveness interacted to predict adolescent resting RSA. Low-aversive teens with highly aversive mothers had the highest RSA, whereas teens in high-high dyads showed the lowest RSA. CONCLUSIONS These findings are consistent with theories that emotion invalidation and conflict escalation are possible contextual risk factors for self-injury.

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“…Bär et al 189 Davidson et al 190 188 Dawood et al 110 Khaykin et al 191 Koschke et al 116 Lederbogen et al 192 Prasko et al 76 Rechlin 194 Rechlin 194 Rechlin et al 196 Tucker et al 83 Udupa et al 197 Udupa et al 198 Yeragani et al 201 189 Khaykin et al 191 Lederbogen et al 192 McLeod et al 193 Rechlin 194 Rechlin et al 195 Rechlin et al 195 Rechlin et al 196 Tulen et al 129 Udupa et al 198 Yeragani et al 199 Yeragani et al 200 …”

Section: Bär Et Almentioning

confidence: 99%

“…Duplicates were removed, titles and abstracts scanned, potential articles read and evaluated against inclusion criteria and authors contacted for additional data when necessary. In total, 140 case-control and 30 treatment 76,83,93,110,116,129,138,141,155,175,[187][188][189][190][191][192][193][194][195][196][197][198][199][200][201][202][203][204][205][206] studies were eligible for inclusion in the quantitative synthesis (151 case-control and 43 effect sizes for analysis); 10 of the studies were included in both the case-control and treatment analyses. 76,83,93,110,116,129,138,141,155,175 Four subgroups of disorders (mood, anxiety-related, psychotic and substance dependence disorders) and 2 classes of psychotropic medications (antidepressants and antipsychotics) were included.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis

Alvares

Quintana

Hickie

et al. 2016

jpn

365

345

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Differential actions of antidepressant treatments on cardiac autonomic alterations in depression: A prospective comparison

Cited by 36 publications

References 25 publications

Comparative Study of Heart Rate Variability in Patients with Schizophrenia, Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder

Comparative Study of Heart Rate Variability in Patients with Schizophrenia, Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder

Mechanisms of Contextual Risk for Adolescent Self-Injury: Invalidation and Conflict Escalation in Mother–Child Interactions

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis

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