Differential abnormalities of the head and body of the caudate nucleus in attention deficit-hyperactivity disorder

Tremols, Virginia; Bielsa, Anna; Soliva, Joan-Carles; Raheb, Carol; Carmona, Susanna; Tomàs, Josep; Gispert, Juan Domingo; Rovira, Mariana; Fauquet, Jordi; Tobeña, Adolf; Bulbena, Antoni; Vilarroya, Óscar

doi:10.1016/j.pscychresns.2007.04.017

Cited by 35 publications

(26 citation statements)

References 25 publications

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“…The results of diverse studies of the anatomic features of the caudate in ADHD patients have been contradictory. Some studies have reported that the right caudate nucleus is smaller in children with ADHD, 4,[15][16][17] whereas others have found that only the left caudate is smaller in ADHD individuals 5 or that there is no difference. 18 Another study found that the total volume of the caudate was smaller in individuals with ADHD but that this difference disappeared during adolescence.…”

Section: Introductionmentioning

confidence: 98%

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Montes

Ricardo-Garcell

Torre

et al. 2010

jpn

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Background: Magnetic resonance imaging (MRI) studies have shown decreased caudate volumes in individuals with attention deficit hyperactivity disorder (ADHD). However, most of these studies have been carried out in male children. Very little research has been done in adults, and the results obtained in children are difficult to extrapolate to adults. We sought to compare the volume of the caudate of adults with ADHD with that of healthy controls; we also compared these volumes between men and women. Methods: We performed an MRI scan on 20 adults with ADHD (10 men and 10 women) aged 25-35 years and 20 healthy controls matched by age and sex. We used voxel-based morphometry with the DARTEL algorithm for image analyses. We used the specifically designed Friederichsen, Almeida, Serrano, Cortes Test (FASCT) to measure the severity of ADHD; both the self-reported (FASCT-SR) and the observer (FASCT-O) versions were used. Results: The statistical parametric map showed a smaller region with low grey matter volume and a smaller concentration of grey matter in this region of the right caudate in ADHD patients than in health controls, both in the entire sample and within each sex. There was a significant correlation between the volume of this region of the caudate with the number of DSM IV-TR criteria, as well as with the total scores and most of the factors of the FASCT-SR and FASCT-O scales. A separate correlation analysis by sex gave similar results. Limitations: The study design was cross-sectional. Conclusion: The region of the right caudate with low grey matter volume was smaller in adults with ADHD in both sexes and was correlated with ADHD severity.

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Section: Introductionmentioning

confidence: 98%

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Montes

Ricardo-Garcell

Torre

et al. 2010

jpn

View full text Add to dashboard Cite

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“…Different studies have reported that the caudate nuclei of children with ADHD are larger than (Garret et al, 2008;Mataro et al, 1997), smaller than (Castellanos et al, 2003;Hynd et al, 1993;Mahone et al, 2011;Qiu et al, 2009;Semrud-Clikeman et al, 2000) or equal to (Hill et al, 2003) those of normal controls. In addition, the typical asymmetry of the caudate nucleus (right > left) has been reported to be either absent or reversed in children with ADHD (Tremols et al, 2008;Uhlikova et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Smaller volumes of caudate nuclei in prepubertal children with ADHD: Impact of age

Carrey¹,

Bernier²,

Emms³

et al. 2012

Journal of Psychiatric Research

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“…Teniendo en cuenta estos estudios previos, la reducción en el volumen de sustancia gris en áreas estriatales observadas en participantes con una alta sr podría relacionarse con una mayor respuesta hacia estímulos reforzantes (Barrós-Loscertales y cols., 2006). De esta forma, los individuos con una mayor sr podrían generar mayores respuestas de aproximación ante estímulos apetitivos, más conductas impulsivas y, en casos extremos, podrían desarrollar trastornos del control de impulsos, como tdAh (Castellanos, 2002;Tremols y cols., 2008), obesidad (Shott y cols., 2014) o abuso de sustancias (Barrós-Loscertales y cols., 2011; Moreno-López y cols., 2012).…”

Section: Discusión Y Conclusionesunclassified

Diferencias anatómicas asociadas a la sensibilidad al castigo y a la recompensa: un estudio de morfometría basada en el vóxel

Adrián‐Ventura¹,

Costumero²,

Barrós‐Loscertales³

et al. 2017

AgoraSalut

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Diferencias anatómicas associades a la sensibilidad al castigo y a la recompensa: un estudio de morfometría basada en el vóxel resumen introducción: La teoría de la sensibilidad al refuerzo (tsr) propone el sistema de activación conductual (sAc) como el sistema motivacional encargado de dirigir la conducta hacia la obtención de estímulos apetitivos. A nivel neurobiológico, este sistema se ha relacionado con el circuito cerebral de la recompensa. Así mismo, se ha propuesto el rasgo de personalidad de sensibilidad a la recompensa (sr) como modulador de la actividad del sAc. En el presente trabajo estudiamos la relación entre la actividad del sAc, medida por medio del cuestionario spsrQ, y el volumen de sustancia gris en áreas de recompensa. métodos: Realizamos un análisis de morfometría basada en el vóxel (VBm) en una muestra de 216 hombres e investigamos la asociación entre los valores de volumen obtenidos y las puntuaciones en la escala sr del spsrQ mediante un análisis de regresión. El procesado y análisis de las imágenes se realizó mediante spm8. resultados: A nivel cortical, los análisis de VBm mostraron una correlación negativa entre las puntuaciones de la escala sr y el volumen de sustancia gris en el córtex prefrontal lateral, la ínsula y el lóbulo temporal superior. A nivel subcortical, observamos una reducción en el volumen del estriado (núcleo caudado). Conclusiones: Nuestros resultados apoyan investigaciones previas y aportan nuevas evidencias acerca de las diferencias anatómicas en áreas relacionadas con el control inhibitorio y la toma de decisiones en participantes con un sAc sobreactivado.palabras clave: recompensa, morfometría, córtex prefrontal, estriado, modelo de Gray. Abstract introduction:The Reinforcement Sensitivity Theory (rst) proposes the Behavioral Activation System (BAs) as the motivational system responsible for direct behavior to-10 àgorA de sAlut. Vol. iV. issn: 2443-9827. doi: http://dx

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Differential abnormalities of the head and body of the caudate nucleus in attention deficit-hyperactivity disorder

Cited by 35 publications

References 25 publications

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Smaller volumes of caudate nuclei in prepubertal children with ADHD: Impact of age

Diferencias anatómicas asociadas a la sensibilidad al castigo y a la recompensa: un estudio de morfometría basada en el vóxel

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