Differente Muster regionaler Hirnaktivität nach emotionaler Stimulation bei alexithymen Patienten im Vergleich zu Normalpersonen

Huber, Michael; Herholz, Karl; Habedank, Birgit; Thiel, Alexander; Müller-Küppers, M; Ebel, Hermann; Subič-Wrana, Claudia; Köhle, Karl; Heiss, Wolf‐Dieter

doi:10.1055/s-2002-35276

Cited by 28 publications

(14 citation statements)

References 15 publications

(22 reference statements)

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“…Thus, their results suggest that alexithymia is related to less ACC activation. In line with this, Huber et al (2002) and Kano et al (2003), using PET, both demonstrated that alexithymics showed less activation in the anterior cingulate cortex than nonalexithymics, while looking at angry faces or during autobiographical recall of emotional situations. Berthoz et al (2002) obtained results that are more complicated.…”

Section: Alexithymia and The Anterior Cingulatesupporting

confidence: 58%

“…Furthermore, these authors failed to find this relationship in females. Huber et al (2002) demonstrated in a PET study that alexithymic subjects showed less activation in the corpus callosum in response to emotional stimuli compared to nonalexithymics. However, Kano et al (2003), who also measured brain activity using PET, reported the opposite result.…”

Section: Alexithymia and The Corpus Callosummentioning

confidence: 99%

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Cognitive neuropsychology of alexithymia: Implications for personality typology

Bermond¹,

Vorst²,

Moormann³

2006

Cognitive Neuropsychiatry

101

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The following conclusions and/or propositions are presented: The right hemisphere produces a global, nonverbal overview of emotional information; the left hemisphere seems dedicated to analysing emotions and higher explicit emotional cognitions. Both orbitoprefrontal cortices are important in affective aspects of alexithymia, while right temporal cortex is involved in cognitive aspects. Two subparts of anterior cingulate fulfil functions in the affective and cognitive dimensions of alexithymia. The amygdalae are involved in both cognitive and affective aspects. All structures mentioned can modulate one another. The role of interhemispheric information transfer via the corpus callosum and the anterior commissure is also discussed. The evidence that that cognitive processing of emotional information inhibits affective processing of such information is discussed in terms of its implications for a theory of alexithymia subtypes.

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Section: Alexithymia and The Anterior Cingulatesupporting

confidence: 58%

Section: Alexithymia and The Corpus Callosummentioning

confidence: 99%

Cognitive neuropsychology of alexithymia: Implications for personality typology

Bermond¹,

Vorst²,

Moormann³

2006

Cognitive Neuropsychiatry

101

View full text Add to dashboard Cite

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“…An anatomical or functional alteration in one of these regions and its underlying pharmacology could therefore affect other linked functions [52,53,54]. Several neuroimaging studies point to significant functional [50,55,56,57] and anatomical [58] alterations in the right anterior cingulate cortex, posterior cingulate cortex [59] and in other prefrontal areas [50, 56, 57] as well as in the corpus callosum [55] of alexithymic subjects during emotional processing. In normal subjects, Critchley et al [60] showed that the anterior cingulate cortex is involved in the regulation of autonomic activity.…”

Section: Discussionmentioning

confidence: 99%

Interhemispheric Transfer Deficit in Alexithymia: A Transcranial Magnetic Stimulation Study

Romei

Gennaro

Fratello

et al. 2008

Psychother Psychosom

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Background: A deficit in interhemispheric transfer was hypothesized in alexithymia more than 30 years ago, following the observation that split-brain patients manifest certain alexithymic characteristics. However, direct evidence of interhemispheric transfer deficit has never been provided. This study investigated the hypothesis of a transcallosal interhemispheric transfer deficit in alexithymia by means of paired-pulse transcranial magnetic stimulation. Methods: A random sample of 300 students was screened for alexithymia using the Italian version of the 20-item Toronto Alexithymia Scale. Eight right-handed males and eight females with high alexithymic scores and an age- and gender-matched group with low alexithymic scores were selected. A first (conditioning) magnetic stimulus was delivered to one motor cortex followed by a second (test) stimulus to the opposite hemisphere at different interstimulus intervals for both motor cortices. Motor evoked responses were recorded from the abductor digit minimi muscles. Results: High alexithymic subjects showed reduced transcallosal inhibition as compared to low alexithymic subjects at interstimulus intervals of 10, 12 and 14 ms in the left-to-right and right-to-left interhemispheric transfer directions. Conclusions: Results point to functional differences in transcallosal interactions in high alexithymic as compared to low alexithymic subjects, supporting the hypothesis of an interhemispheric transfer deficit in alexithymia.

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“…Während negativer Affektinduktion sind bei Hochalexithymen verglichen mit Niedrigalexithymen insbesondere verminderte Aktivitäten in umschriebenen Arealen des medialen präfrontalen Kortex (Brodmann-Area 9) [25,26] Originalarbeit turen signifikant häufiger bei den Normalpersonen aktiviert waren. Leider wurde in dieser Studie die Depressivität nicht hinreichend kontrolliert.…”

Section: Introductionunclassified

Neuronale Aktivitätsmuster auf affektinduktive Reize bei Alexithymie

Leweke

Stark²,

Milch³

et al. 2004

Psychother Psychosom Med Psychol

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In alexithymia a frontal dysfunction is supposed to be a neurobiological correlate. This study focuses on distorted patterns of neuronal activity evoked by emotional stimuli in alexithymics and controls. Out of hospitalised patients with psychosomatic diseases 8 patients with a high score (HA) and 8 with a low one (NA) on the TAS-20 were investigated with fMRI during emotional stimulation which included pictures evoking anxiety and disgust as well as neutral illustrations. As response to negative affect arousing visual stimulation HA in comparison to NA showed a lower activation in the right medial prefrontal cortex and in the right amygdala. The results were significant for the emotion disgust. The results support the existence of a complex central feedback circuit consisting of regions of the prefrontal cortex and limbic structures to process negative affects. Hypothetically a fundamental factor for the emergence of alexithymic traits is an inhibiting process between affect processing (e. g. medial prefrontal cortex, anterior cingulum) and affect generating structures (e. g. amygdala). Furthermore our findings confirm the hypothesis that alexithymia is a disorder of higher cerebral function.

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Differente Muster regionaler Hirnaktivität nach emotionaler Stimulation bei alexithymen Patienten im Vergleich zu Normalpersonen

Cited by 28 publications

References 15 publications

Cognitive neuropsychology of alexithymia: Implications for personality typology

Cognitive neuropsychology of alexithymia: Implications for personality typology

Interhemispheric Transfer Deficit in Alexithymia: A Transcranial Magnetic Stimulation Study

Neuronale Aktivitätsmuster auf affektinduktive Reize bei Alexithymie

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