Different therapeutic strategies in primary salivary gland-type nasopharyngeal carcinomas

Liu, Tian Run; Chen, Fu Jin; Zhang, Guan Ping; Yang, An Kui

doi:10.1097/moo.0b013e3283448402

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…As most NPCs are poorly differentiated [27], the poorly differentiated cell line HNE-2 was selected for further studies. As Akt pathway signaling can lead to apoptosis, we next sought to determine the effect of SPLUNC1 on the expression and activation of pro-apoptotic proteins.…”

Section: Resultsmentioning

confidence: 99%

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Chen

Guo²,

Zhou³

et al. 2013

PLoS ONE

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Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.

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Section: Resultsmentioning

confidence: 99%

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Chen

Guo²,

Zhou³

et al. 2013

PLoS ONE

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“…Several studies recommended that surgery combined with radiotherapy may be the main treatment policy for limited and resectable NPACs, such as adenoid cystic carcinoma, mucoepidermoid carcinoma, and well-differentiated adenocarcinoma. 6 , 17 A retrospective study by Liu et al 16 revealed that the overall survival in T1–T2 patients was significantly improved comparing combined surgical treatment group (n=12) with the nonsurgical (radiotherapy) treatment group (n=12; P =0.041). Multivariate analysis also indicated that surgical treatment was an independent predictor of survival in such patients ( P =0.017), which is consistent with the results of Guo et al 4 and Liu et al 18 However, some studies revealed that the addition of PORT could not bring survival benefit for early-stage (stages I and II) patients with clear margin and without adverse prognostic factors such as lymphovascular or perineural invasion, which is a set of conditions usually restricted to low-grade variants.…”

Section: Discussionmentioning

confidence: 99%

Low-grade nasopharyngeal papillary adenocarcinoma: a case report and review of the literature

Wang¹,

Huang²,

Luo³

et al. 2016

OTT

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Low-grade nasopharyngeal papillary adenocarcinoma is an extremely rare tumor, with only a limited number of cases reported in the literature. Some published studies have paid more attention to the clinicopathological features of nasopharyngeal adenocarcinoma, while little effort has been made to study the optimal therapeutic strategies. We report about a woman diagnosed with low-grade nasopharyngeal papillary adenocarcinoma. She received the treatment approach that combined transnasal endoscopic surgery to remove the lesion with postoperative radiotherapy for nasal cavity. There was no evidence of recurrence after 4 months of surgery, and further follow-up is being continued. Through this example, we wanted to explore the optimal therapeutic strategies for primary nasopharyngeal adenocarcinomas.

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“…Multiple treatment modalities exist for the treatment of salivary gland tumors of the nasopharynx [8]. Generally low-grade salivary gland tumors are less radiosensitive than their high-grade counterpart [9].…”

Section: Discussionmentioning

confidence: 99%

An endonasal approach to the resection of a papillary seromucinous adenocarcinoma of the Eustacian tube

Glicksman

Franklin

Shepherd

et al. 2013

Journal of Otolaryngology - Head & Neck Surgery

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ObjectivesPapillary seromucinous adenocarcinoma of the sinonasal tract is exceedingly rare. The objectives of this case report are to describe a case of papillary seromucinous adenocarcinoma presenting in the nasopharynx and to review the literature pertaining to other similar cases.MethodsA review of the patient's chart and a review of the English literature were conducted.ResultsWe describe the case of a 64 year-old woman who presented with a 3-year history of epistaxis and right-sided otitis media with effusion. The patient had been followed for a known nasopharyngeal mass that had twice been biopsied and in both cases was considered a benign mass pathologically. A third biopsy was diagnosed as a low-grade papillary seromucinous adenocarcinoma. The patient was otherwise asymptomatic. The patient was referred to a multidisciplinary cancer clinic at which endoscopic resection was determined to be the preferred treatment modality. A literature review and approach to patients with nasopharyngeal masses will be presented.ConclusionsPapillary seromucinous adenocarcinoma is a rare tumor that can present in the nasopharynx. We describe the endoscopic surgical management of one such patient that presented to our care.

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Different therapeutic strategies in primary salivary gland-type nasopharyngeal carcinomas

Cited by 9 publications

References 26 publications

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Low-grade nasopharyngeal papillary adenocarcinoma: a case report and review of the literature

An endonasal approach to the resection of a papillary seromucinous adenocarcinoma of the Eustacian tube

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